• Mashup Score: 14
    Hallmarks of Cancer: New Dimensions - 2 year(s) ago

    The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CD_AACR

      Next Dimension Hallmark— Polymorphic #microbiomes: The vast array of microbes present within us can affect cancer development, progression, and therapy response. https://t.co/nkwkorTcYT #HallmarksofCancer https://t.co/WK1g9Xiglm

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      CD_AACR

      In celebration of the new #HallmarksofCancer, we are sharing each of the parts added to the ring over the last 20 years. Don’t forget to share your favorites! https://t.co/nkwkorTcYT https://t.co/YS8I6P6tFK

  • Mashup Score: 14
    Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer–Associated Fibroblasts - 2 year(s) ago

    Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant and transcriptionally diverse CAF population in pancreatic ductal adenocarcinoma (PDAC) is thought to arise from a common cell of origin, pancreatic stellate cells (PSC), with diversification resulting from cytokine and growth…

    Source: Cancer Discovery
    Categories: Latest Headlines, Oncologists1
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      whitefishlab

      Yet more beautiful work from the @MaraShermanLab now out in: @CD_AACR.https://t.co/GhgC6HszOo. With a perspective by @ednacukierman: https://t.co/HGFu9Kuend

    • Profile photo of CD_AACR
      CD_AACR

      RT @whitefishlab: Yet more beautiful work from the @MaraShermanLab now out in: @CD_AACR.https://t.co/GhgC6HszOo. With a perspective by @ed…

  • Mashup Score: 10
    The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs - 2 year(s) ago

    Summary: Cancer-associated fibroblast (CAF) pro– and anti–pancreatic cancer functional dichotomy has been at the center of numerous studies. In this issue of Cancer Discovery , Helms and colleagues demonstrate that although pancreatic stellate cell–derived CAFs constitute a desmoplastic cell minority, these cells play a protumorigenic role via microenvironmental mechanomodulation. See related…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CD_AACR

      In the Spotlight: The few yet Fabp4ulous pancreatic stellate cells give rise to pro-tumoral CAFs by @ednacukierman, @FoxChaseCancer. https://t.co/5fKMX0FItR https://t.co/uD7Zf22MYZ

  • Mashup Score: 31
    Hallmarks of Cancer: New Dimensions - 2 year(s) ago

    The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
    Tweet Tweets with this article
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      CD_AACR

      New Dimension Hallmark: Senescent cells: denoted as a significant contributor to the #tumormicroenvironment, these cells can affect tumor development and progression #HallmarksofCancer. https://t.co/QOCv75pvpp https://t.co/6ZmsAe18C1

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      CD_AACR

      In celebration of the new #HallmarksofCancer, we will be sharing each of the 14 parts that have been added to the hallmarks ring over the last 20 years. Be sure to share your favorite! https://t.co/QOCv75pvpp https://t.co/I1yzpokeZY

  • Mashup Score: 0
    Improving the Affordability of Anticancer Medicines Demands Evidence-Based Policy Solutions - 2 year(s) ago

    The high cost of many new anticancer medicines significantly impedes breakthrough discoveries from reaching patients. A commonly heard refrain is that high prices are necessary to compensate for the high costs of research and development (R&D). Yet, there are promising policy proposals aimed at improving affordability without compromising innovation. In seeking new policy solutions, we argue for…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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    • Profile photo of CD_AACR
      CD_AACR

      Science in Society: Improving the affordability of anticancer medicines demands evidence-based policy solutions by @WimvanHarten, @NKI_nl, @utwenteEN, @UvA_Amsterdam, @Rijnstate. https://t.co/KlsHG1D8ch https://t.co/KLEZCqOwVz

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