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Mashup Score: 3
Background: Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on tissue function through metabolism remains largely unexplored. Objectives: This study aims to investigate the impacts of polymer microspheres on tissue metabolism in mice by assessing the microspheres ability to translocate across the gut barrier and enter into systemic circulation. Specifically, we wanted to examine microsphere accumulation in different organ sys
Source: ehp.niehs.nih.govCategories: General Medicine News, NeurologyTweet
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Mashup Score: 9
Background: Respiratory distress is the leading cause of neonatal morbidity and mortality worldwide, and prenatal exposure to air pollution is associated with adverse long-term respiratory outcomes; however, the impact of prenatal air pollution exposure on neonatal respiratory distress has not been well studied. Objectives: We examined associations between prenatal exposures to fine particular matter (PM2.5) and nitrogen dioxide (NO2) with respiratory distress and related neonatal outcomes. Methods: We used data from the Maternal–Infant Research on Environmental Chemicals (MIREC) Study, a prospective pregnancy cohort (n=2,001) recruited in the first trimester from 10 Canadian cities. Prenatal exposures to PM2.5 (n=1,321) and NO2 (n=1,064) were estimated using land-use regression and satellite-derived models coupled with ground-level monitoring and linked to participants based on residential location at birth. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for associ
Source: ehp.niehs.nih.govCategories: General Medicine News, General HCPsTweet-
Prenatal #airPollution exposure linked to severe newborn #respiratoryDistress @penn_state https://t.co/Ofj2euvYQo https://t.co/NpDOMFgyHE
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Mashup Score: 14
Background: Phthalates are endocrine-disrupting chemicals linked to adverse pregnancy outcomes. Despite the sensitivity of female reproductive processes to oxidation–reduction reaction stress and endocrine disruption, evidence for the impact of women’s phthalate exposure on the ability to establish and maintain pregnancy has been inconclusive. Objectives: We aimed to determine the relationship of preconception phthalate metabolite exposure with a) fecundability and pregnancy loss and b) markers of potential biological mechanisms, including reproductive hormones, inflammation, and oxidative stress. Methods: Data were collected from the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial, a preconception study following 1,228 women who were attempting pregnancy, for up to six menstrual cycles and throughout pregnancy if they became pregnant. Twenty phthalate metabolites were measured in a consecutive 3-d pooled urine sample at enrollment. Pregnancy was determined through urina
Source: ehp.niehs.nih.govCategories: General Medicine News, General HCPsTweet-
Exposure to chemicals found in many #householdProducts can lower odds of getting pregnant @umassamherst https://t.co/XsXnQcg3yE https://t.co/v2oaUzvzXY
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Mashup Score: 37
Background: Ambient air pollution may be a developmental endocrine disruptor. In animal models, gestational and perinatal exposure to diesel exhaust and concentrated particulate matter alters anogenital distance (AGD), a marker of prenatal androgen activity, in both sexes. Little is known in humans. Objectives: We examined exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) in relation to human AGD at birth and at 1 year of age, focusing on exposures during critical windows of reproductive development: the male programming window (MPW; gestational weeks 8–14) and mini-puberty (postnatal months 1–3). Methods: The Infant Development and Environment Study (TIDES) recruited first trimester pregnant women (n=687) at four U.S. sites (Minneapolis, Minnesota; Rochester, New York; San Francisco, California; and Seattle, Washington) from 2010 to 2012. We measured anus to clitoris (AGD-AC) and anus to fourchette (AGD-AF) in female infants at birth; in males, we measured anus to
Source: ehp.niehs.nih.govCategories: General Medicine News, General HCPsTweet-
Prenatal exposure to #airpollution may lower semen quality and increase the risk of #reproductive system disease in 🧔🏽♂️ men, new research finds. #climate #Health #ClimateJustice https://t.co/8EUcn2puWT https://t.co/wALGo4vltB
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Mashup Score: 37
Background: Ambient air pollution may be a developmental endocrine disruptor. In animal models, gestational and perinatal exposure to diesel exhaust and concentrated particulate matter alters anogenital distance (AGD), a marker of prenatal androgen activity, in both sexes. Little is known in humans. Objectives: We examined exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) in relation to human AGD at birth and at 1 year of age, focusing on exposures during critical windows of reproductive development: the male programming window (MPW; gestational weeks 8–14) and mini-puberty (postnatal months 1–3). Methods: The Infant Development and Environment Study (TIDES) recruited first trimester pregnant women (n=687) at four U.S. sites (Minneapolis, Minnesota; Rochester, New York; San Francisco, California; and Seattle, Washington) from 2010 to 2012. We measured anus to clitoris (AGD-AC) and anus to fourchette (AGD-AF) in female infants at birth; in males, we measured anus to
Source: ehp.niehs.nih.govCategories: General Medicine News, General HCPsTweet-
Prenatal exposure to #airpollution may lower semen quality and increase the risk of #reproductive system disease in 🧔🏽♂️ men, new research finds. #climate #Health #ClimateJustice https://t.co/8EUcn2puWT https://t.co/wALGo4vltB
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Mashup Score: 4
Background: Herbicides are the most used class of pesticides worldwide, and insect repellents are widely used globally. Yet, there is a dearth of studies characterizing the associations between these chemical groups and human neurobehavior. Experimental studies suggest that glyphosate and 2,4-dichlorophenoxyacetic acid (2,4-D) herbicides can affect neurobehavior and the cholinergic and glutamatergic pathways in the brain. We aim to assess whether herbicides and insect repellents are associated with neurobehavioral performance in adolescents. Methods: We assessed 519 participants (11–17 years of age) living in agricultural communities in Ecuador. We quantified urinary concentrations of glyphosate, 2,4-D, and two N,N-diethyl-meta-toluamide (DEET) insect repellent metabolites [3-(diethylcarbamoyl)benzoic acid (DCBA) and 3-(ethylcarbamoyl)benzoic acid (ECBA)] using isotope-dilution mass spectrometry. We assessed neurobehavioral performance using 9 subtests across 5 domains (attention/inhib
Source: ehp.niehs.nih.govCategories: Latest Headlines, NeurologyTweet-
“Urinary glyphosate, 2,4-D and DEET biomarkers in relation to neurobehavioral performance in Ecuadorian adolescents in the ESPINA cohort” by Jose Ricardo Suarez et al. Environmental Health Perspectives https://t.co/yVInSdJ2E8 2/2
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Mashup Score: 3Long-term Exposure to Walkable Residential Neighborhoods Reduces the Risk of Obesity-related Cancer in Women | ISEE | 2022 - 7 month(s) ago
Background and Aim Living in neighborhoods with higher levels of walkability has been associated with a reduced risk of obesity and higher levels of physical activity. Obesity has been linked to increased risk of 13 cancers in women. However, long-term prospective studies of neighborhood walkability (NW) and risk for obesity-related cancer are scarce. In this prospective study, we evaluated the association between average NW and risk of cancer. Methods In the New York University Women’s Health Study (NYUWHS), a prospective cohort with 14,274 women recruited between 1985 and 1991 in New York City and followed over nearly three decades, we geocoded residential addresses for each participant throughout follow-up. We calculated an average annual measure of neighborhood walkability across years of follow-up using data on population density and accessibility to destinations associated with geocoded residential addresses. We employed Cox proportional hazards models to assess the association b
Source: ehp.niehs.nih.govCategories: Hem/Oncs, Latest HeadlinesTweet-
Abstract - data from >14,000 women ages 35-65, found that those who live in walkable neighborhoods have lower rates of obesity-related cancers (postmenopausal breast cancer, ovarian cancer, endometrial cancer and multiple myeloma) #mmsm #disparities https://t.co/hBcTeLvGB2
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Long-term Exposure to Walkable Residential Neighborhoods Reduces the Risk of Obesity-related Cancer in Women | ISEE | 2022 https://t.co/45Wo54pk7G
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Mashup Score: 5
Background: Per- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche. Methods: In a cohort of Greater Cincinnati (GC) and San Francisco Bay Area (SFBA) girls recruited at 6–8 years of age, clinical examinations were conducted annually or semiannually with sequential Tanner staging. PFAS concentrations were measured in the first serum sample of 704 girls. In 304 GC girls, estradiol (E2), estrone (E1), testosterone (T), and dihydroepiandrosterone sulfate (DHEAS) were measured in serum at four time points around puberty. Relationships between PFAS and age at thelarche, pubarche, and menarche were analyzed using survival and structural equation models. The association between PFAS and reproductive hormones w
Source: ehp.niehs.nih.govCategories: General Medicine News, Latest HeadlinesTweet-
Research shows PFAS exposure may delay girls' puberty @UofCincy https://t.co/FsageEduC9 https://t.co/Rawh41CAgv
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Mashup Score: 1
Background: The geographic range of the tick Amblyomma americanum, a vector of diseases of public health significance such as ehrlichiosis, has expanded from the southeast of the United States northward during the 20th century. Recently, populations of this tick have been reported to be present close to the Canadian border in Michigan and New York states, but established populations are not known in Canada. Previous research suggests that changing temperature patterns with climate change may influence tick life cycles and permit northward range expansion of ticks in the northern hemisphere. Objectives: We aimed to estimate minimal temperature conditions for survival of A. americanum populations at the northern edge of the tick’s range and to investigate the possibility of range expansion of A. americanum into northern U.S. states and southern Canada in the coming decades. Methods: A simulation model of the tick A. americanum was used, via simulations using climate data from meteorologi
Source: ehp.niehs.nih.govCategories: Hem/Oncs, Latest HeadlinesTweet-
Climate change is expanding the Lone Star Tick’s range northward. Expect to see a lot more Alpha-Gal syndrome (AGS) in the coming decades. https://t.co/n5zU4pvWb9 https://t.co/myI00LSzv9
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“In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice” by Eliseo Castillo et al. Environmental Health Perspectives https://t.co/cev4ZZFMeU 3/3