-
Mashup Score: 0Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function - 1 year(s) ago
Extracellular dopamine (DA) levels are constrained by the presynaptic DA transporter (DAT), a major psychostimulant target. Despite its necessity for DA neurotransmission, DAT regulation in situ is poorly understood, and it is unknown whether regulated DAT trafficking impacts dopaminergic signaling and/or behaviors. Leveraging chemogenetics and conditional gene silencing, we found that activating…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
-
Mashup Score: 0
Dendritic cells (DCs) present foreign antigens to T cells via the major histocompatibility complex (MHC), thereby inducing acquired immune responses. ATP accumulates at sites of inflammation or in tumor tissues, which triggers local inflammatory responses. However, it remains to be clarified how ATP modulates the functions of DCs. In this study, we investigated the effects of extracellular ATP on…
Source: Journal of Biological ChemistryCategories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 0The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors - 1 year(s) ago
The histamine H3 receptor (H3R) is highly enriched in the spiny projection neurons (SPNs) of the striatum, in both the D1 receptor (D1R)–expressing and D2 receptor (D2R)–expressing populations. A crossantagonistic interaction between H3R and D1R has been demonstrated in mice, both at the behavioral level and at the biochemical level. Although interactive behavioral effects have been described…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
-
Mashup Score: 0Click chemistry and optogenetic approaches to visualize and manipulate phosphatidic acid signaling - 1 year(s) ago
The simple structure of phosphatidic acid (PA) belies its complex biological functions as both a key phospholipid biosynthetic intermediate and a potent signaling molecule. In the latter role, PA controls processes including vesicle trafficking, actin dynamics, cell growth, and migration. However, experimental methods to decode the pleiotropy of PA are sorely lacking. Because PA metabolism and…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
-
Mashup Score: 0Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site - 1 year(s) ago
AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the response to energy challenges to maintain cellular ATP levels. AMPK is a potential therapeutic target for treating metabolic disorders, and several direct synthetic activators of AMPK have been developed that show promise in preclinical models of type 2 diabetes. These compounds have been shown to regulate AMPK…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
-
Mashup Score: 0Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site - 1 year(s) ago
AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the response to energy challenges to maintain cellular ATP levels. AMPK is a potential therapeutic target for treating metabolic disorders, and several direct synthetic activators of AMPK have been developed that show promise in preclinical models of type 2 diabetes. These compounds have been shown to regulate AMPK…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
-
Mashup Score: 0
SOX2 and SOX15 are Sox family transcription factors enriched in embryonic stem cells (ESCs). The role of SOX2 in activating gene expression programs essential for stem cell self-renewal and acquisition of pluripotency during somatic cell reprogramming is well-documented. However, the contribution of SOX15 to these processes is unclear and often presumed redundant with SOX2 largely because…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
-
Mashup Score: 0s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons - 1 year(s) ago
A hippocampal mossy fiber synapse implicated in learning and memory is a complex structure in which a presynaptic bouton attaches to the dendritic trunk by puncta adherentia junctions (PAJs) and wraps multiply branched spines. The postsynaptic densities (PSDs) are localized at the heads of each of these spines and faces to the presynaptic active zones. We previously showed that the scaffolding…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
-
Mashup Score: 0Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site - 1 year(s) ago
AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the response to energy challenges to maintain cellular ATP levels. AMPK is a potential therapeutic target for treating metabolic disorders, and several direct synthetic activators of AMPK have been developed that show promise in preclinical models of type 2 diabetes. These compounds have been shown to regulate AMPK…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
-
Mashup Score: 0
Tapasin (Tsn) plays a critical role in antigen processing and presentation by major histocompatibility complex class I (MHC-I) molecules. The mechanism of Tsn-mediated peptide loading and exchange hinges on the conformational dynamics governing the interaction of Tsn and MHC-I with recent structural and functional studies pinpointing the critical sites of direct or allosteric regulation. In this…
Source: Journal of Biological ChemistryCategories: Allergy-Immunology, Latest HeadlinesTweet
Kearney et al.'s results demonstrate that regulated DA transporter (DAT) trafficking is significantly more complex than had been previously appreciated. https://t.co/SzmIhFgzlK