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Mashup Score: 3
Context.—. Standardized bone marrow reporting specifically for myelodysplastic syndromes/neoplasms (MDS) is currently lacking in the literature and much needed in practice.Objective.—. To propose a standardized approach to MDS evaluation in bone marrow specimens by (1) enhancing interinstitutional and intrainstitutional collaborations and clinical decision-making among hematopathologists and clinical hematologists and (2) allowing for efficient data extraction for clinical trials, institutional databases, and registry templates. This suggested approach is summarized in a modifiable, user-friendly template for hematopathologists to reference as they examine bone marrows (in the Supplemental Digital Content).Data Sources.—. We built upon the bone marrow template reporting guideline outlined by the College of American Pathologists Pathology and Laboratory Quality Center for Evidence-Based Guidelines and gathered expert insight from hematopathologists and hematologists-oncologists who spec
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
ABSTRACT. Aerial translocation of captured black rhinoceroses (Diceros bicornis) has been accomplished by suspending them by their feet. We expected this posture would compromise respiratory gas exchange more than would lateral recumbency. Because white rhinoceroses (Ceratotherium simum) immobilized with etorphine alone are hypermetabolic, with a high rate of carbon dioxide production (VCO2), we expected immobilized black rhinoceroses would also have a high VCO2. Twelve (nine male, three female; median age 8 yr old [range: 4–25]; median weight 1,137 kg [range: 804–1,234] body weight) wild black rhinoceroses were immobilized by aerial darting with etorphine and azaperone. The animals were in lateral recumbency or suspended by their feet from a crane for approximately 10 min before data were collected. Each rhinoceros received both treatments sequentially, in random order. Six were in lateral recumbency first and six were suspended first. All animals were substantially hypoxemic and hype
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
For those eager to learn more, here’s the paper: https://t.co/tuhuE2Pvkp 8/8
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Mashup Score: 5Current Approach to Undifferentiated Neoplasms, With Focus on New Developments and Novel Immunohistochemical Stains - 4 month(s) ago
Context.—. Workup of the poorly differentiated or undifferentiated tumor remains a significant and challenging entity in the practice of anatomic pathology. Particularly in the setting of small biopsies and limited material, these cases demand a balanced approach that considers the patient’s clinical and radiologic presentation, a basic assessment of tumor morphology, a reasonably broad immunohistochemical panel, and diligent preservation of tissue for prognostic and therapeutic studies.Objective.—. To illustrate some of the new and emerging immunohistochemical markers in the evaluation of tumors with undifferentiated or poorly differentiated morphology, with a focus on the workup in limited tissue samples to raise awareness of the issues involved with the pathologic workup in these challenging tumors.Data Sources.—. A literature review of new ancillary studies that can be applied to cytologic specimens was performed.Conclusions.—. Knowledge of the patient’s history and communication w
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
OK, this is a crazy busy flow chart do aid with diagnosis of undifferentiated carcinoma, an entity that is not all that uncommon and increasingly classified using molecular methods... More here - excellent paper: https://t.co/Jn6ENdLBih https://t.co/QuXEjZj6fg
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Mashup Score: 6Texas Heart Institute Journal | Allen Press - 5 month(s) ago
ANNOUNCEMENT: The Texas Heart Institute Journal is now indexed in the DOAJ. Read more. For 50 years, The Texas Heart Institute Journal has been published by The Texas Heart Institute as part of its medical education program. Our continuously published, peer-reviewed journal enjoys a global audience of physicians, scientists, and healthcare professionals who are contributing to the prevention, diagnosis, and treatment of cardiovascular disease… Read More About The Journal This site uses cookies. By
Source: meridian.allenpress.comCategories: General Medicine News, Cardiology News and JournTweet-
📓 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐌𝐚𝐧𝐮𝐬𝐜𝐫𝐢𝐩𝐭𝐬 The @Texas_Heart Journal invites authors to contribute across various article types. Submit ➡️ https://t.co/LmWCFmZeLk 𝐒𝐮𝐛𝐦𝐢𝐬𝐬𝐢𝐨𝐧 𝐭𝐨 𝐏𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐀𝐯𝐞𝐫𝐚𝐠𝐞 𝟮𝟲 𝐖𝐞𝐞𝐤𝐬. #THIJournal #MedTwitter #CardioX https://t.co/Augjg8QQpO
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Mashup Score: 1Surgical Repair of Postinfarction Left Ventricular Pseudoaneurysm - 5 month(s) ago
Abstract. Left ventricular pseudoaneurysm is a serious and rare disorder that usually develops after acute myocardial infarction. It can lead to potentially lethal mechanical complications, such as acute left ventricular free wall rupture. This report presents the case of a 64-year-old man with a left ventricular pseudoaneurysm and myocardial rupture that was managed by left ventricular restoration with aneurysmectomy and coronary artery bypass with 2 grafts.
Source: meridian.allenpress.comCategories: General Medicine News, CardiologistsTweet-
New from the #THIJournal: Soon Jin Kim, MD, and colleagues at Jeonbuk National University College of Medicine describe the surgical repair of a rare case of left ventricular pseudoaneurysm and myocardial rupture: https://t.co/uR72WEcBSx #THIJournal #CABG #myocardialinfarction https://t.co/sjNsrQW0Rm
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Mashup Score: 3Prevalence of Cardiometabolic Risk Factors in Women: Insights From the Houston HeartReach Study - 6 month(s) ago
AbstractBackground:. Cardiovascular disease is the leading cause of death among women in the United States. Past research has highlighted the importance of the relationship between female-specific demographics and traditional risk factors. The present analysis aimed to identify the prevalence of modifiable risk factors in women attending a community cardiovascular health screening.Methods:. Data collected between 2011 and 2019 were obtained from the Houston HeartReach Registry. Participants were classified as having or not having each of 4 traditional cardiometabolic risk factors: hypertension, diabetes, body mass index indicating overweight or obesity, and dyslipidemia. Differences in prevalence were compared using the Pearson χ2 test.Results:. Most participants had hypertension, overweight or obesity, and dyslipidemia. Older women (≥65 years) had the highest prevalence of all cardiometabolic risk factors. Black participants had a higher prevalence of hypertension (P = .006) and a low
Source: meridian.allenpress.comCategories: General Medicine News, CardiologistsTweet-
A new study from the @Texas_Heart Journal shows differences in cardiometabolic risk factors for women by race, income & zip code. ➡️ Learn more & see how #SDOH play a role: https://t.co/rsfmpa2OdR #HoustonHeartReach #HoustonHealth #WomensHealth #THIJPubs #THIJournal https://t.co/AM0Aj4nILX
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Mashup Score: 3A Eulogy for the Match - 6 month(s) ago
September 27, 2028.The Match died today. The cause of death was indifference.The Match was born in 1951 to Francis Joseph Mullin and John Marshall Stalnaker.1 Early on, it had several congenital disorders corrected by future pediatric surgeon W. Hardy Hendren III,2 leading to the National Resident Matching Program (NRMP) that we know today.3 In 1998, The Match received care from Drs. Alvin E. Roth and Elliott Peranson, allowing it to accommodate couples, myriad specialties, and DO applicants.4 For his work, Dr. Roth won the 2012 Nobel Prize in Economics.5During its heyday, the Match served nearly 50 000 registrants, boasting decades-long streaks of year-over-year increases in applications and positions. Success came with controversy. In 2003, residents sued the NRMP in a monopoly lawsuit. However, Congress gave the Match antitrust protection akin to that of Major League Baseball.6 Afterwards, the Match consolidated its power, showing swagger with its 2012 all-in policy that required pr
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
RT @Midwest_MedPeds: I’ll just park this here https://t.co/cPJi42HBZl @CincyIM @DEWeber_MDMEd @JournalofGME #MedEd https://t.co/rGcuYBK0…
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Mashup Score: 1
Cardiac contractility modulation delivers an electrical current during the absolute refractory period, 30 milliseconds to 40 milliseconds after detection of local myocardial activation and without generating an action potential or cellular contraction (ie, “nonexcitatory”). Studies have demonstrated that these signals modulate action potential duration, contractility, and cardiac relaxation through cellular mechanisms involving sarcoplasmic reticulum calcium entry.1 In addition, improvements in global and regional contractility suggestive of reverse remodeling have been demonstrated in small-cohort studies.2,3 Cardiac contractility modulation may provide a benefit to patients with heart failure (HF) for whom implantable cardioverter-defibrillator implantation and cardiac resynchronization therapy (CRT) are not recommended as well as to specific patients with New York Heart Association (NYHA) class III symptoms and a left ventricular ejection fraction (LVEF) of 25% to 45%.4For patients
Source: meridian.allenpress.comCategories: General Medicine News, CardiologistsTweet-
Drs. Joshua R. Hirsch and Hamid Afshar of @BCM_Heart & @VAHouston briefly review the use of cardiac contractility modulation in a subset of patients with #heartfailure, including those for whom #ICD and #CRT are not recommended. @JRH_MD #THIJournal https://t.co/XP1GCOV4Fz
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Mashup Score: 1
ABSTRACT. Clear cell renal cell carcinoma (RCC) is commonly associated with alterations in the VHL tumor suppressor gene, resulting in upregulation of hypoxia-inducible factor pathways. Immune checkpoint inhibitors and vascular endothelial growth factor inhibitors are the mainstays of systemic treatment for metastatic RCC; however, most patients encounter disease progression after the initial response. The phase 3 clinical trial LITESPARK-005–belzutifan (HIF-2α inhibitor) demonstrated improvement in progression-free survival compared with everolimus in heavily pretreated patients unselected for somatic/germline VHL alterations (an objective response rate of 23% and a median time on therapy of 7.6 months in the belzutifan cohort), resulting in U.S. FDA approval for patients with advanced RCC. Herein, we present two cases of refractory metastatic RCC (including one with brain metastases) with somatic VHL mutations who received belzutifan after discussion in the institutional Molecular Tu
Source: meridian.allenpress.comCategories: General Medicine News, Oncologists1Tweet-
RT @JIPOEditors: Thapa et al. present two successful cases on treatment of somatic VHL alterations w belzutifan https://t.co/O2AvQ76QwM #re…
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Mashup Score: 0Fulminant Myocarditis in Patients With Autoimmune Disease That Requires Extracorporeal Membrane Oxygenation Support - 6 month(s) ago
Abstract. Myocarditis is a potentially life-threatening inflammatory disease of the myocardium, often resulting from infectious and immune-mediated responses. Clinical presentation in severe cases often results in a devastating illness requiring extracorporeal membrane oxygenation support as a result of cardiogenic shock. Although endomyocardial biopsy is still considered the gold standard for diagnosis, it often reveals nonspecific lymphocytic infiltration. Because the precise cause is usually unknown, the initial treatment typically involves immunosuppression and frequent assessment of myocardial contractility. This report presents 3 rare cases of autoimmune diseases (polymyositis, immunoglobulin G4–related disease, and systemic lupus erythematosus) that require extracorporeal membrane oxygenation support as a result of fulminant myocarditis, including their follow-up periods.
Source: meridian.allenpress.comCategories: General Medicine News, Cardiology News and JournTweet-
In the #THIJournal, Dr. Filip Depta and colleagues from Slovakia and the Czech Republic share three rare cases of patients with autoimmune-mediated myocarditis who required ECMO support, from symptoms to follow-up: https://t.co/uYbw40Ysrh #ECMO #myocarditis #autoimmune https://t.co/0BvVgtSoII
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Congratulations to @Savanaplastic and @MinaXu7 for leading this effort out today in @ArchivesPath hope to see this guideline paper from the @ic_MDS be adopted as a framework for comprehensive reporting of #MDSsm Link to paper https://t.co/H8IYP4UyAo #hemepath @Dr_AmerZeidan https://t.co/qKwE0mF9Vp