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Mashup Score: 20
ABSTRACT. Leukemic masses are a known complication in patients with hematologic malignancies. Here we present a case regarding a patient with recently diagnosed B-acute lymphoblastic leukemia (B-ALL) who presented with multiple sites of extramedullary involvement including an anterior mediastinal mass. This mass persisted despite multiple rounds of multiagent cytotoxic therapy. In this report, we summarize the literature regarding mediastinal masses in the setting of B-ALL and illustrate that such masses in patients with leukemias may have surprising etiology, separate from the primary disease.
Source: meridian.allenpress.comCategories: General Medicine NewsTweet
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Mashup Score: 0
JQSH Learning Corner | Global Journal on Quality and Safety in Healthcare JQSH Quality and Safety Learning Corner The JQSH Quality and Safety Learning Corner is educational platform for those are interested in building their knowledge and resources for use in the quality and safety implementation sciences. This special section includes short articles with useful information on the concepts, methodology, and tools…
Source: meridian.allenpress.comCategories: General Medicine NewsTweet-
The learning corning at #JQSH has many useful tools and concepts written in concise way. #quality #healthcare https://t.co/MoVL84Bfy1
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Mashup Score: 39Pembrolizumab in Patients with Advanced Miscellaneous Rare Cancers: Results from a Phase 2 Basket Trial - 3 month(s) ago
ABSTRACTIntroduction. Rare solid tumors account for one-quarter of cancers among adults in the United States, but few resources have been devoted to their treatment. We evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with rare solid tumors.Methods. We conducted a phase 2 basket trial that included patients with rare, advanced tumors. Patients were enrolled in the study in nine tumor-specific and a 10th cohort of miscellaneous rare histologies. Patients received pembrolizumab 200 mg intravenously every 21 days. The primary endpoint was the non-progression rate at 27 weeks per immune-related Response Evaluation Criteria in Solid Tumors (RECIST). The secondary endpoints were confirmed objective response (immune-related complete response [irCR] or partial response [irPR]), clinical benefit (irCR, irPR, or immune-related stable disease [irSD] โฅ 4 months), safety, and tolerability. Pretreatment biopsy specimens were examined for programmed cell death
Source: meridian.allenpress.comCategories: General Medicine NewsTweet-
โญ๏ธNice to see this published ๐๐ผ #Immunotherapy in some of the rarest of the rare tumors ๐๐ผPembrolizumab in Patients with Advanced Miscellaneous Rare Cancers: Results from a Phase 2 Basket Trial @mirella_nardo @ANaingMD ๐๐ผ๐๐ผ๐๐ผ @DavidHongMD @OncoAlert https://t.co/7Hp6WgaVru
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Mashup Score: 3
Context.โ. Standardized bone marrow reporting specifically for myelodysplastic syndromes/neoplasms (MDS) is currently lacking in the literature and much needed in practice.Objective.โ. To propose a standardized approach to MDS evaluation in bone marrow specimens by (1) enhancing interinstitutional and intrainstitutional collaborations and clinical decision-making among hematopathologists and clinical hematologists and (2) allowing for efficient data extraction for clinical trials, institutional databases, and registry templates. This suggested approach is summarized in a modifiable, user-friendly template for hematopathologists to reference as they examine bone marrows (in the Supplemental Digital Content).Data Sources.โ. We built upon the bone marrow template reporting guideline outlined by the College of American Pathologists Pathology and Laboratory Quality Center for Evidence-Based Guidelines and gathered expert insight from hematopathologists and hematologists-oncologists who spec
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
Congratulations to @Savanaplastic and @MinaXu7 for leading this effort out today in @ArchivesPath hope to see this guideline paper from the @ic_MDS be adopted as a framework for comprehensive reporting of #MDSsm Link to paper https://t.co/H8IYP4UyAo #hemepath @Dr_AmerZeidan https://t.co/qKwE0mF9Vp
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Mashup Score: 3
ABSTRACT. Aerial translocation of captured black rhinoceroses (Diceros bicornis) has been accomplished by suspending them by their feet. We expected this posture would compromise respiratory gas exchange more than would lateral recumbency. Because white rhinoceroses (Ceratotherium simum) immobilized with etorphine alone are hypermetabolic, with a high rate of carbon dioxide production (VCO2), we expected immobilized black rhinoceroses would also have a high VCO2. Twelve (nine male, three female; median age 8 yr old [range: 4โ25]; median weight 1,137 kg [range: 804โ1,234] body weight) wild black rhinoceroses were immobilized by aerial darting with etorphine and azaperone. The animals were in lateral recumbency or suspended by their feet from a crane for approximately 10 min before data were collected. Each rhinoceros received both treatments sequentially, in random order. Six were in lateral recumbency first and six were suspended first. All animals were substantially hypoxemic and hype
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
For those eager to learn more, hereโs the paper: https://t.co/tuhuE2Pvkp 8/8
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Mashup Score: 5Current Approach to Undifferentiated Neoplasms, With Focus on New Developments and Novel Immunohistochemical Stains - 7 month(s) ago
Context.โ. Workup of the poorly differentiated or undifferentiated tumor remains a significant and challenging entity in the practice of anatomic pathology. Particularly in the setting of small biopsies and limited material, these cases demand a balanced approach that considers the patientโs clinical and radiologic presentation, a basic assessment of tumor morphology, a reasonably broad immunohistochemical panel, and diligent preservation of tissue for prognostic and therapeutic studies.Objective.โ. To illustrate some of the new and emerging immunohistochemical markers in the evaluation of tumors with undifferentiated or poorly differentiated morphology, with a focus on the workup in limited tissue samples to raise awareness of the issues involved with the pathologic workup in these challenging tumors.Data Sources.โ. A literature review of new ancillary studies that can be applied to cytologic specimens was performed.Conclusions.โ. Knowledge of the patientโs history and communication w
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
OK, this is a crazy busy flow chart do aid with diagnosis of undifferentiated carcinoma, an entity that is not all that uncommon and increasingly classified using molecular methods... More here - excellent paper: https://t.co/Jn6ENdLBih https://t.co/QuXEjZj6fg
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Mashup Score: 6Texas Heart Institute Journal | Allen Press - 8 month(s) ago
ANNOUNCEMENT: The Texas Heart Institute Journal is now indexed in the DOAJ. Read more. For 50 years, The Texas Heart Institute Journal has been published by The Texas Heart Institute as part of its medical education program. Our continuously published, peer-reviewed journal enjoys a global audience of physicians, scientists, and healthcare professionals who are contributing to the prevention, diagnosis, and treatment of cardiovascular disease… Read More About The Journal This site uses cookies. By
Source: meridian.allenpress.comCategories: General Medicine News, Cardiology News and JournTweet-
๐ ๐๐๐ฅ๐ฅ ๐๐จ๐ซ ๐๐๐ง๐ฎ๐ฌ๐๐ซ๐ข๐ฉ๐ญ๐ฌ The @Texas_Heart Journal invites authors to contribute across various article types. Submit โก๏ธ https://t.co/LmWCFmZeLk ๐๐ฎ๐๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง ๐ญ๐จ ๐๐ฎ๐๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง ๐๐ฏ๐๐ซ๐๐ ๐ ๐ฎ๐ฒ ๐๐๐๐ค๐ฌ. #THIJournal #MedTwitter #CardioX https://t.co/Augjg8QQpO
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Mashup Score: 1Surgical Repair of Postinfarction Left Ventricular Pseudoaneurysm - 9 month(s) ago
Abstract. Left ventricular pseudoaneurysm is a serious and rare disorder that usually develops after acute myocardial infarction. It can lead to potentially lethal mechanical complications, such as acute left ventricular free wall rupture. This report presents the case of a 64-year-old man with a left ventricular pseudoaneurysm and myocardial rupture that was managed by left ventricular restoration with aneurysmectomy and coronary artery bypass with 2 grafts.
Source: meridian.allenpress.comCategories: General Medicine News, CardiologistsTweet-
New from the #THIJournal: Soon Jin Kim, MD, and colleagues at Jeonbuk National University College of Medicine describe the surgical repair of a rare case of left ventricular pseudoaneurysm and myocardial rupture: https://t.co/uR72WEcBSx #THIJournal #CABG #myocardialinfarction https://t.co/sjNsrQW0Rm
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Mashup Score: 3Prevalence of Cardiometabolic Risk Factors in Women: Insights From the Houston HeartReach Study - 9 month(s) ago
AbstractBackground:. Cardiovascular disease is the leading cause of death among women in the United States. Past research has highlighted the importance of the relationship between female-specific demographics and traditional risk factors. The present analysis aimed to identify the prevalence of modifiable risk factors in women attending a community cardiovascular health screening.Methods:. Data collected between 2011 and 2019 were obtained from the Houston HeartReach Registry. Participants were classified as having or not having each of 4 traditional cardiometabolic risk factors: hypertension, diabetes, body mass index indicating overweight or obesity, and dyslipidemia. Differences in prevalence were compared using the Pearson ฯ2 test.Results:. Most participants had hypertension, overweight or obesity, and dyslipidemia. Older women (โฅ65 years) had the highest prevalence of all cardiometabolic risk factors. Black participants had a higher prevalence of hypertension (P = .006) and a low
Source: meridian.allenpress.comCategories: General Medicine News, CardiologistsTweet-
A new study from the @Texas_Heart Journal shows differences in cardiometabolic risk factors for women by race, income & zip code. โก๏ธ Learn more & see how #SDOH play a role: https://t.co/rsfmpa2OdR #HoustonHeartReach #HoustonHealth #WomensHealth #THIJPubs #THIJournal https://t.co/AM0Aj4nILX
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Mashup Score: 3A Eulogy for the Match - 9 month(s) ago
September 27, 2028.The Match died today. The cause of death was indifference.The Match was born in 1951 to Francis Joseph Mullin and John Marshall Stalnaker.1 Early on, it had several congenital disorders corrected by future pediatric surgeon W. Hardy Hendren III,2 leading to the National Resident Matching Program (NRMP) that we know today.3 In 1998, The Match received care from Drs. Alvin E. Roth and Elliott Peranson, allowing it to accommodate couples, myriad specialties, and DO applicants.4 For his work, Dr. Roth won the 2012 Nobel Prize in Economics.5During its heyday, the Match served nearly 50โ000 registrants, boasting decades-long streaks of year-over-year increases in applications and positions. Success came with controversy. In 2003, residents sued the NRMP in a monopoly lawsuit. However, Congress gave the Match antitrust protection akin to that of Major League Baseball.6 Afterwards, the Match consolidated its power, showing swagger with its 2012 all-in policy that required pr
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
RT @Midwest_MedPeds: Iโll just park this here https://t.co/cPJi42HBZl @CincyIM @DEWeber_MDMEd @JournalofGME #MedEd https://t.co/rGcuYBK0โฆ
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๐ Check out our report in @JIPOEditors led by Dr @LuanPhanMD - time to brush up on your DDX for a mediastinal mass - what are your top entities on your differential for thinking ๐ค about #mediastinalmasses ? Do you have a #pneumonic ? #meded @mtmdphd https://t.co/x603QFrugp https://t.co/qvWZqxU54O