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Mashup Score: 6A Holistic Framework for the Evaluation of Kidney Function in a Gender-Diverse Landscape - 3 hour(s) ago
The most commonly used equations to estimate glomerular filtration rate incorporate a binary male-female sex coefficient, which has important implications for the care of transgender, gender-diverse, and nonbinary (TGD) people. Whether “sex assigned at birth“ or a binary “gender identity“ is most appropriate for the computation of estimated glomerular filtration rate (eGFR) is unknown. Furthermore, the use of gender-affirming hormone therapy (GAHT) for the development of physical changes to align TGD people with their affirmed gender is increasingly common, and may result in changes in serum creatinine and cystatin C, the biomarkers commonly used to estimate glomerular filtration rate.
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Mashup Score: 5Development and Validation of the Rating of CKD Knowledge Among Older Adults (Know-CKD) with Kidney Failure - 15 hour(s) ago
Few older adults with kidney failure engage in shared decision-making (SDM) for kidney replacement therapy. Absence of instruments assessing SDM-relevant knowledge domains may contribute to this. We assessed the reliability and validity of a new instrument, the Rating of CKD Knowledge Older Adults (Know-CKD).
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Mashup Score: 10
In 1988, the American Board of Internal Medicine (ABIM) defined essential procedural skills in nephrology, and candidates for ABIM certification were required to present evidence of possessing the skills necessary for placement of temporary dialysis vascular access, hemodialysis, peritoneal dialysis, and percutaneous renal biopsy. In 1996, continuous renal replacement therapy was added to the list of nephrology requirements. These procedure requirements have not been modified since 1996 while the practice of nephrology has changed dramatically.
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Mashup Score: 9American Journal of Kidney Diseases - 2 day(s) ago
These articles highlight various types of disparities that impact patients with kidney diseases and call attention to more research that is necessary to achieve the goal of global health
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Mashup Score: 16Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates - 2 day(s) ago
Children born before 28 weeks’ gestation are at increased risk of chronic kidney disease (CKD). Urine biomarkers may shed light on mechanistic pathways and improve the ability to forecast CKD. We evaluated whether urinary biomarkers in neonates of low gestational age (GA) are associated with a reduced estimated glomerular filtration rate (eGFR) over time.
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Mashup Score: 20
A 68-year-old woman being treated with hemodialysis for autosomal dominant polycystic kidney disease was admitted for progressive dyspnea over 6 months. On chest radiography, her cardiothoracic ratio had increased from 52.2% 6 months prior, to 71%, and echocardiography revealed diffuse pericardial effusion and right ventricular diastolic insufficiency. A resultant pericardial tamponade was thought to be the cause of the patient’s dyspnea, and therefore a pericardiocentesis was performed, with a total of 2,000mL of fluid removed.
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Mashup Score: 33
APOL1 (OMIM 603743) -encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against African trypanosomiasis (1) (2). Two African ancestry–related APOL1 gain-of-function haplotypes, G1 and G2, individually confer enhanced protection against human African trypanosomiasis (HAT) (3) (4). Non-G1, non-G2 haplotypes are referred to as the G0, reference or the wild-type allele (5). In a landmark discovery, the recessively inherited higher risk of chronic kidney disease (CKD) with the in-trans combinations of these two APOL1 haplotypes (G1/G1, G2/G2, or G1/G2 termed APOL1 high-risk genotype) when compared to the low-risk genotype (G0/G0, G0/G1, or G0/G2) was described (3) (4).
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 7
People with diabetes who are receiving dialysis for kidney failure are at high risk of cardiovascular disease and death. This study uses information from 1446 people from seven European countries who have kidney failure, are receiving dialysis, have type 2 diabetes, and are prescribed either insulin identical to that made in the body (human insulin) or insulins with engineered extra features (insulin analog). After three years, fewer participants receiving analog insulins had died, had been admitted to the hospital, or had a cardiovascular event (heart attack, stroke, heart failure or peripheral vascular disease). These findings suggest that analog insulins should be further explored as treatment leading to better outcomes for people with diabetes on dialysis.
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Mashup Score: 31AJKD Atlas of Renal Pathology: Acute Pyelonephritis - 4 day(s) ago
Acute uncomplicated pyelonephritis is most commonly due to bacterial infection ascending from the lower urinary tract, and occurs more often in young adult women, 15 to 29 years old, who are sexually active; this is on account of the shorter urethra in women and its potential contamination with intestinal bacteria. As discussed in the following, complicated acute pyelonephritis has predisposing findings. The incidence is estimated to be 15 to 17 cases per 10,000 women, contrasting 3 to 4 cases per 10,000 men.
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Mashup Score: 8
A 47-year-old man with acute worsening of chronic diarrhea was admitted to the hospital with a serum creatinine of 2.2mg/dL from a baseline of 1.6mg/dL. Medical history was remarkable for type 1 diabetes mellitus (diagnosed 8 years prior) complicated by kidney failure requiring kidney-pancreas transplant (cytomegalovirus [CMV] IgG-positive donor; CMV IgG-negative recipient) 3 years before presentation. The patient reported having long-standing diarrhea with 5 to 8 bowel movements per day for 25 years.
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