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Mashup Score: 33X-linked myopathy with excessive autophagy: characterization and therapy testing in a zebrafish model | EMBO Molecular Medicine - 19 day(s) ago
imageimageX-linked myopathy with excessive autophagy (XMEA) is a rare disease for which pre-clinical models lack, challenging the ability to understand mechanisms and therapies. The use of the zebrafish to model XMEA was investigated for its …
Source: www.embopress.orgCategories: General Medicine NewsTweet
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Mashup Score: 2Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation | EMBO reports - 2 month(s) ago
imageimageThis study presents and characterizes a Dnmt3a mutant mouse model which carries a heterozygous hotspot R878H mutation frequently found in human cancers, providing insights into Dnmt3a-mutant haematologic disease. Dnmt3aR878H/+ cells …
Source: www.embopress.orgCategories: General Medicine NewsTweet-
Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation https://t.co/JwBs1wBErm
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Mashup Score: 23Alpha-synuclein misfolding as fluid biomarker for Parkinson’s disease measured with the iRS platform | EMBO Molecular Medicine - 2 month(s) ago
imageimageA new fluid biomarker for Parkinson’s disease (PD) was developed, offering a high-accuracy biological classification, potentially at early stages. A discovery and a validation cohort consisting of 134 individuals was analyzed, using α-…
Source: www.embopress.orgCategories: General Medicine NewsTweet-
A #SpinalFluid biomarker enables early and accurate #Parkinson'sDisease diagnosis, detecting misfolded alpha-synuclein with over 90% sensitivity and specificity before severe brain damage occurs. @ruhrunibochum https://t.co/BlskmN8lYQ https://t.co/eThuZE5vMd
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Mashup Score: 19Alpha-synuclein misfolding as fluid biomarker for Parkinson’s disease measured with the iRS platform | EMBO Molecular Medicine - 2 month(s) ago
imageimageA new fluid biomarker for Parkinson’s disease (PD) was developed, offering a high-accuracy biological classification, potentially at early stages. A discovery and a validation cohort consisting of 134 individuals was analyzed, using α-…
Source: www.embopress.orgCategories: General Medicine NewsTweet-
A #SpinalFluid biomarker enables early and accurate #Parkinson'sDisease diagnosis, detecting misfolded alpha-synuclein with over 90% sensitivity and specificity before severe brain damage occurs. @ruhrunibochum https://t.co/BlskmN8lYQ https://t.co/eThuZE5vMd
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Mashup Score: 1Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer | The EMBO Journal - 4 month(s) ago
imageimageAneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through integrative proteogenomic analysis of evolved aneuploid cell lines and primary tumors, this study identifies …
Source: www.embopress.orgCategories: General Medicine News, Hem/OncsTweet-
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer https://t.co/D5ioCLlGas
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Mashup Score: 0Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type | EMBO reports - 4 month(s) ago
imageimageThis study presents an integrated RNA-seq and ChIP-seq analysis after in vivo whole-body radiation of isogenically matched mouse strains. Mutant 172H p53 is shown to occupy genes and regulate their expression via non-canonical means that …
Source: www.embopress.orgCategories: General Medicine News, Hem/OncsTweet-
@NicoGagelmann @AjHematology Wanna collaborate on mutant p53 (fundamental/translational work)? See our latest paper: https://t.co/HLoE7lBPe0
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Mashup Score: 60Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors | EMBO Molecular Medicine - 5 month(s) ago
imageimageMicrobe-derived indoles modulate anxiety and neuronal excitability in the amygdala of germ-free (GF) male mice. These findings demonstrate a molecular mechanism by which microbes tune anxiety-related behavior. Elevated anxiety was …
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet-
#GutMicrobes may influence #Anxiety through microbial metabolites like indoles, suggesting potential probiotic therapies. This gut-brain connection could revolutionize #MentalHealth treatments. @dukenus https://t.co/mzxbeR67yz https://t.co/cgl4Y42otR
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Mashup Score: 32The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women | EMBO reports - 6 month(s) ago
imageimageThe risk variant rs57141087 is predominant in Black women and modulates TRIM37 levels through enhancer-promoter interactions. TRIM37 overexpression in early stages promotes neoplastic transformations, accelerates tumorigenesis, and …
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet-
A potential biomarker, TRIM37, may explain the high rates of aggressive triple-negative breast #Cancer in Black women. This discovery could enhance diagnosis and prognosis, offering new hope for targeted treatments. @emboreports https://t.co/WdVGccBphK https://t.co/Ui6veevJZH
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Mashup Score: 183What is a PhD? | EMBO reports - 6 month(s) ago
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet-
RT @isciverse: What is a PhD? Open Access https://t.co/MIOg83X4zB #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #R…
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Mashup Score: 6Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging | The EMBO Journal - 7 month(s) ago
imageimageAging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging mouse brain at the single-cell level in vivo by profiling two optical reporter models. Differences across brain …
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet-
“Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging” by Anna Rappe et al. EMBO Journal https://t.co/S84fbhxiIz
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#A zebrafish model of XMEA, an ultra-rare genetic muscle disease, has enabled identification of two drug candidates that significantly improve disease symptoms in preclinical testing. https://t.co/Rv3C04DKee https://t.co/v7dbEETtpB