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Mashup Score: 2Diacron-reactive oxygen metabolites levels are initially elevated in bullous pemphigoid patients - 8 day(s) ago
Reactive oxygen species (ROS) are involved in the pathogenesis of bullous pemphigoid (BP), but this involvement has not been fully elucidated. In this study, to further elucidate the pathogenic role of ROS in BP, we examined the results of the diacron-reactive oxygen metabolite (d-ROMs) test and the biological antioxidant potential test for 16 BP patients who visited our hospital before being treated with systemic corticosteroids. In the BP patients, the average d-ROMs levels, expressed in Carratelli units (U.CARR), were significantly reduced at 1 month of treatment (from 335.6 ± 40.3 U.CARR to 224.7 ± 61.6 U.CARR, P<0.001).
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 7Dupilumab therapy modulates circulating inflammatory mediators in patients with prurigo nodularis - 11 day(s) ago
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus and skin nodules. Beyond the skin, PN involves circulating blood inflammation that may contribute to systemic disease comorbidities. Dupilumab was recently approved for treatment of PN, but its effects on systemic inflammation are unknown. Thus, we aimed to characterize changes in plasma concentrations of inflammatory proteins following dupilumab treatment. In this exploratory study, plasma samples were collected from three patients with moderate-to-severe PN before and after ≥6 months of dupilumab.
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 1Home Page: JID Innovations - 12 day(s) ago
Published online: August 9, 2023 Published online: February 8, 2023 Published online: July 4, 2023 The IF image shows a mitotic keratinocyte with NuMA, a protein required for orienting the spindle, in green, microtubules in red, and the condensed DNA is blue. The model shows some of the molecular machinery that promotes spindle orientation. NuMA (blue) is recruited to the cell cortex by LGN (green). NuMA both directly binds microtubules and recruits the dynein/dynactin complex (red) to generate the
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 7Dupilumab therapy modulates circulating inflammatory mediators in patients with prurigo nodularis - 15 day(s) ago
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus and skin nodules. Beyond the skin, PN involves circulating blood inflammation that may contribute to systemic disease comorbidities. Dupilumab was recently approved for treatment of PN, but its effects on systemic inflammation are unknown. Thus, we aimed to characterize changes in plasma concentrations of inflammatory proteins following dupilumab treatment. In this exploratory study, plasma samples were collected from three patients with moderate-to-severe PN before and after ≥6 months of dupilumab.
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 5Aims and Scope: JID Innovations - 1 month(s) ago
JID Innovations is an online-only Open Access journal that provides an international forum for the rapid publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. Submissions should address questions that are important and relevant to the community of
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 5Aims and Scope: JID Innovations - 2 month(s) ago
JID Innovations is an online-only Open Access journal that provides an international forum for the rapid publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. Submissions should address questions that are important and relevant to the community of
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 5Aims and Scope: JID Innovations - 3 month(s) ago
JID Innovations is an online-only Open Access journal that provides an international forum for the rapid publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. Submissions should address questions that are important and relevant to the community of
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 2
Rates of melanoma—the deadliest form of skin cancer—have increased. Early detection can save lives, and patients have a critical role to play in checking their skin. We aim to identify health communication messages that best educate the public and increase intentions toward skin checks. After viewing messages intended to increase melanoma knowledge, participants correctly identified a greater proportion (74.6 vs 70.4%) of moles (mean number = 17.9, 95% confidence interval [CI] = 17.5–18.3 vs 16.9, 95% CI = 16.6–17.3; P < .001, partial eta-squared = 0.03) and had knowledge of more melanoma warning signs (mean number = 5.8, 95% CI = 5.7–5.8 vs 5.6, 95% CI = 5.5–5.7, P = .01, partial eta-squared = 0.02).
Source: www.jidinnovations.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Aims and Scope: JID Innovations - 4 month(s) ago
JID Innovations is an online-only Open Access journal that provides an international forum for the rapid publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. Submissions should address questions that are important and relevant to the community of
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 1Aims and Scope: JID Innovations - 5 month(s) ago
JID Innovations is an online-only Open Access journal that provides an international forum for the rapid publication of high-quality, peer reviewed research in the field of skin biology and disease. JID Innovations features original scientific reports related to all aspects of skin science from molecular studies to population health, including studies addressing the pathogenesis and treatment of skin diseases. Submissions should address questions that are important and relevant to the community of
Source: www.jidinnovations.orgCategories: General Medicine News, DermatologyTweet
New players, new targets for BP--dROMs https://t.co/2CPSy0ewCA #dermtwitter #medderm #pemphigoid https://t.co/yKzpJPIe2j