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Mashup Score: 2All-Cause and Cause-Specific Mortality among Patients with Vitiligo: A Nationwide Population-Based Study in Korea - 4 month(s) ago
Vitiligo is a common autoimmune skin disorder; however, there is limited information about risks of mortality among patients with vitiligo. Therefore, we aimed to investigate the mortality in patients with vitiligo. A population-based cohort study was conducted using the data linkage of the National Health Insurance Service database and the National Death Registry. Patients with incident vitiligo were matched with sociodemographic factors–matched controls without vitiligo in a 1:5 ratio. All-cause and cause-specific mortalities were compared between patients with vitiligo and controls.
Source: www.jidonline.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 4Romidepsin and afatinib abrogate JAK-STAT signaling and elicit synergistic antitumor effects in cutaneous T-cell lymphoma - 4 month(s) ago
Cutaneous T-cell lymphomas (CTCL) are mature lymphoid neoplasias resulting from the malignant transformation of skin-resident T cells. A distinctive clinical feature of CTCL is their sensitivity to treatment with histone deacetylase (HDAC) inhibitors. However, responses to HDAC inhibitor therapy are universally transient and non-curative, highlighting the need for effective and durable drug combinations. Here we demonstrate that the combination of romidepsin, a selective class I HDAC inhibitor, with afatinib, an epidermal growth factor receptor (EGFR) family inhibitor, induces strongly synergistic antitumor effects in CTCL models in vitro and in vivo via abrogation of JAK-STAT signalling.
Source: www.jidonline.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 10Unraveling the Mechanisms of PD-1 Regulation in Sézary Syndrome: Epigenetic Regulation as Potential Mechanism? - 6 month(s) ago
In their recent article in the Journal of Investigative Dermatology, Najidh et al. (2023) expanded our understanding of PD-1 regulation in Sézary syndrome (SS), demonstrating an inverse correlation between DNA methylation status of PDCD1 gene promotor and PDCD1 gene and PD-1 protein expression that strongly indicates a role for DNA methylation in regulating PDCD1 gene expression.
Source: www.jidonline.orgCategories: General Medicine News, DermatologyTweet
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Mashup Score: 0Will Electronic Skins Be the Next Miraculous Skin Care Devices? - 8 month(s) ago
The concept of a second skin or electronic skin (e-skin) is currently a hot topic, reflecting technological advances in electronics, polymers, and nanotechnology, but this subject has not yet reached the mainstream of skin biologists, dermatologists, and the wider medical community. These recently developed devices are proving to be useful in monitoring systemic health across the skin surface with far greater precision than typical electrode-based devices. Moreover, e-skins are being designed to extract and monitor samples of body fluids continuously as well as to improve transdermal drug delivery.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1
Itch is a common symptom of skin conditions such as psoriasis (Elewski et al., 2019). The processing of itch-related information can be influenced by implicit processes such as biased avoidance tendencies (Silverberg et al., 2018; Verhoeven et al., 2006) and attentional biases (Evers et al., 2019; van Laarhoven et al., 2020), which can amplify the sensation of itch. These processes can especially affect those with chronic itch and their significant others (SOs), because they may be exposed to itch-related stimuli more often than the general public.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0Neuroanatomic Signatures in Brachioradial Pruritus, Chronic Prurigo, and Atopic Dermatitis - 8 month(s) ago
In September 2022, Agelopoulos et al. (2023) published an investigation on the density and distribution of intraepithelial sensory nerve fibers using pan-neuronal marker, protein gene product 9.5, in skin biopsies from patients with chronic nodular prurigo (CNPG), atopic dermatitis (AD), and brachioradial pruritus (BRP) and from healthy controls. In addition to a reduced number of intraepidermal nerve fibers in biopsies from all patients compared with those from healthy controls, different neuronal branching patterns were recognized in CNPG, BGP, and AD (Agelopoulos et al., 2023).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1Real-World Implementation and Outcomes of Adalimumab Therapeutic Drug Monitoring in Psoriasis: A National Specialized Center Experience - 8 month(s) ago
Serum adalimumab concentration is a biomarker of treatment response but therapeutic drug monitoring (TDM) is yet to be implemented in routine psoriasis care. We incorporated adalimumab TDM in a national specialized psoriasis service and evaluated it using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) implementation science framework. We undertook pre-implementation planning (validating local assays) and implementation interventions targeted to patients (pragmatic sampling at routine reviews), clinicians (introduction of a TDM protocol), and healthcare systems (adalimumab TDM as a key performance indicator).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1The Human Skin Cell Atlas: Mapping the Organ at Unprecedented Depth - 9 month(s) ago
In their recent paper, Almet et al. (2023) provide a framework for the research community aiming to standardize single-cell datasets and find common terminology to more accurately describe cutaneous cell populations and functional cell states. More specifically, the authors propose to construct a Human Skin Cell Atlas mainly derived from single-cell RNA-sequencing studies as part of a worldwide consortium organized by and integrated into the Human Cell Atlas Initiative. As challenging as it may sound, such an undertaking is necessary and worthwhile because it will help to deconvolute complex datasets for the benefit of clarity and reproducibility in cutaneous research.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 5Autophagy Controls the Protein Composition of Hair Shafts - 9 month(s) ago
Hair shafts are formed by a special mode of keratinocyte (KC) differentiation (Harland and Plowman, 2018), which is characterized by the accumulation of hair keratins (keratin [K]31–K40, K81–K90) and keratin-associated proteins, cell death by cornification, and integration of the dead cells into the growing hair shaft (Jones et al., 2018) (Figure 1a). The death of hair KCs is associated with the breakdown of the nucleus and other organelles (Fischer et al., 2011; Jones et al., 2018). Autophagy is a major intracellular degradation process that is controlled by autophagy-related genes (Mizushima and Komatsu, 2011).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 2
As artificial intelligence (AI) continually advances, its potential role in clinical decision making has been increasingly explored. Growing attention has surrounded stress testing the readiness of AI models for clinical utility by quantifying the performance of large language models (LLMs), such as ChatGPT (OpenAI, San Francisco, CA) and its successor GPT-4 (OpenAI), on standardized medical examinations. However, LLMs have predictable limitations, such as older models struggling with higher-order questions (Ali et al., 2023, 2021).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
All-Cause and Cause-Specific Mortality among Patients with Vitiligo: A Nationwide Population-Based Study in Korea. Ju et al. https://t.co/4HAz4NWot9 #dermtwitter #dermatology #dermresearch #dermscience #vitiligo Image Credit: iStock/Narongrit Doungmanee https://t.co/Hln7HzGdYI