• Mashup Score: 8

    Sickle cell disease predisposes patients to hypercoagulability, and pulmonary microthrombosis can contribute to acute chest syndrome even if no

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    • Therapeutic Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease In a randomized trial, symptom resolution was faster with therapeutic than with prophylactic anticoagulation. https://t.co/BpYvAYAmr9 @ClementLeeMD #SickleCellDisease https://t.co/A9qZ0AGHAg

  • Mashup Score: 21

    In early trials, camizestrant, a next-generation selective estrogen receptor degrader (SERD) and complete ER antagonist, demonstrated activity in

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    • For patients with advanced breast cancer who acquire ESR1 mutations during first-line aromatase inhibitor and CDK4/6 inhibitor therapy, switching to camizestrant — before disease progression — improves progression-free survival. https://t.co/l06vS88Mp6 @NEJM @DrWGradishar #bcsm https://t.co/VIgMUWNjAz

  • Mashup Score: 14

    Euglycemic diabetic ketoacidosis (DKA) is relatively uncommon, but its incidence seems to be increasing. Sodium–glucose cotransporter-2 (SGLT-2)

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    • Rise in Euglycemic DKA Might Be Associated with SGLT-2 Inhibitor Use Diabetic ketoacidosis diagnosis was delayed and duration of DKA was longer in patients with euglycemic DKA. https://t.co/bpOdN2DiLc #diabetes @DresslerDD https://t.co/28BAa3A1pO