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Mashup Score: 2Global and Community Health: Neurologic Care and a Case Study for Immigrants and Refugees in West Philadelphia | Neurology - 6 hour(s) ago
Philadelphia is a diverse city that has experienced an increasing immigrant and refugee population in recent decades. Although many academic medical centers also call Philadelphia their home, lack of accessibility and difficulty with insurance limit …
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Mashup Score: 14Immune-Mediated Megaconial Myopathy | Neurology - 11 hour(s) ago
ObjectivesTo describe a novel subtype of autoimmune myopathy, immune-mediated megaconial myopathy (IMMM), myopathologically characterized by giant mitochondria (megaconia).MethodsIn this case series, we reviewed the Mayo Clinic Muscle Pathology database, …
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Mashup Score: 79Progressive Apraxia of Speech as a Manifestation of Spinocerebellar Ataxia 2 | Neurology Genetics - 23 hour(s) ago
ObjectivesTo describe a case of spinocerebellar ataxia presenting with progressive apraxia of speech (AOS).MethodsA 54-year-old man with progressive speech changes was seen clinically and referred to our observational research program on degenerative …
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Mashup Score: 70Teaching NeuroImage: Tigroid Appearance of Cerebellum on MRI in Lhermitte-Duclos Disease | Neurology - 23 hour(s) ago
A 35-year-old woman presented with progressive ataxia, vomiting, and dizziness for a month. A 3T brain MRI scan revealed an enlarged right cerebellar hemisphere (Figure). The tigroid appearance on T2-weighted images was strongly suggestive of Lhermitte-Duclos disease (LDD). Histopathologic examination revealed relatively preserved cerebellar architecture with dysplas tic ganglion cells of variable size without mitosis or necrosis. The patient had no other hamartomatous lesions. Without surgical resection,
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Mashup Score: 7Teaching NeuroImage: Spontaneously Resolving Ring-Enhancing Lesions Due to Immunodeficiency-Associated CNS Lymphoma | Neurology - 1 day(s) ago
A 57-year-old woman with systemic lupus erythematosus on mycophenolate mofetil (MMF) presented after a tonic-clonic seizure. Brain MRI revealed 7 gadolinium-enhancing lesions (Figure 1A). CSF protein, glucose, and cell count were normal, and microbiological tests for opportunist agents were negative, raising our suspicion for lymphoma. Prebiopsy MRI showed spontaneous improvement of most lesions, with increased size of the largest lesion (Figure 1B). Brain biopsy (Figure 2) was consistent with immunodefici
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Mashup Score: 39
Background and ObjectivesRecent technological advances have enabled visualizing in vivo a subset of chronic active brain lesions in persons with multiple sclerosis (pwMS), referred to as “paramagnetic rim lesions” (PRLs), with iron-sensitive MRI. PRLs …
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Mashup Score: 11Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk | Neurology - 1 day(s) ago
Background and ObjectivesThe 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, including stroke, late-life …
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Mashup Score: 144Ideomotor Apraxia and “Milky Way” Sign in Progressive Multifocal Leukoencephalopathy | Neurology - 2 day(s) ago
A 70-year-old woman presented with progressive right arm clumsiness for 1 month (e.g., trouble baking and playing guitar) without weakness or numbness. She had hepatitis C cirrhosis, localized hepatocellular carcinoma treated with radioembolization, and thrombotic thrombocytopenic purpura treated with rituximab 1 year earlier. Neurologic examination revealed ideomotor apraxia (Video 1), 1 mild right astereognosis, and agraphesthesia. MRI brain showed a left frontoparietal T2/FLAIR-hyperintense lesion
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This case highlights the clinical presentation of ideomotor apraxia, the “Milky Way” radiographic sign, the possibility of JC virus PCR being negative in early progressive multifocal leukoencephalopathy (PML) and the hallmark pathologic findings of PML. https://t.co/D1iOm389OC https://t.co/5Ai2faN7Vs
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Mashup Score: 15The More Things Change, the More They Stay the Same: Trends and Disparities In Long-Term Mortality After Stroke | Neurology® Journals - 2 day(s) ago
In the United States, stroke is a leading cause of morbidity and mortality, and its burden is not equally distributed across society. 1 Specifically, Black individuals have a much higher risk of incident stroke, and tend to develop strokes at younger ages. 2 Data on disparities in outcomes after stroke have been inconsistent. The increasing focus on guideline-directed care may have narrowed some racial disparities in outcomes over time. 3 In our paper, Temporal Trends and Racial Disparities in Long-Term
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In the latest DEI blog, "The More Things Change, the More They Stay the Same: Trends and Disparities In Long-Term Mortality After Stroke," Dr. Robinson discusses his recent study on temporal trends & racial disparities in long-term survival after stroke: https://t.co/0z6rGMBLIF https://t.co/oIr35jBNkL
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Mashup Score: 5
Background and ObjectivesDespite increasing interest in post-intensive care unit (ICU) clinical care and management, there have been limited descriptions focused on the post-neurologic (neuro)-ICU population. Here, we describe the design of a post-neuro-…
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Global and Community Health: Neurologic Care and a Case Study for Immigrants and Refugees in West Philadelphia https://t.co/T4cP8XxnLs #NeurologyRF https://t.co/DoRri0a6ep