Alteration of calcium channel signaling may explain the mechanism of autism spectrum disorder

Autism spectrum disorder (ASD) is a heterogeneous disorder initiated early in development and characterized by abnormal social communication. Accumulating evidence supports the idea that specific mutations affect regulatory proteins that control arrays of cellular pathways.

Early Media Exposure and Autism Spectrum Disorder

The rising prevalence of autism spectrum disorder (ASD) has given pause to many epidemiologists and spawned aggressive attempts to search for an explanation. Whatever the underlying genomics of autism are, they cannot explain the increase because they have remained largely unchanged while the…

Scientists uncover new genetic mutations linked to autism spectrum disorder

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Radboud University Medical Center in the Netherlands have identified mutations in a gene called CNOT1 that affect brain development and impair memory and learning. The study is the first to link neurodevelopmental delays with CNOT1, suggesting that drugs that help restore the gene’s function may have therapeutic benefit. The…

Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children

This cohort study estimates the associations between grandparental age at the time their children were born and the risk of autism spectrum disorders in their grandchildren.

Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder

Objective To review pharmacologic and nonpharmacologic strategies for treating sleep disturbances in children and adolescents with autism spectrum disorder (ASD) and to develop recommendations for addressing sleep disturbance in this population. Methods The guideline panel followed the American Academy of Neurology 2011 guideline development process, as amended. The systematic review included…

Discussions Autism (ASD)

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