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Mashup Score: 15Understanding the role of microglia in Alzheimer's disease - 1 month(s) ago
Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer’s. The exact mechanism behind this …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11
The cellular and molecular mechanisms underlying major depressive disorder are unclear. Here, the authors report cell type- and cortical layer-specific gene expression changes and identify one microglia subpopulation associated with depressive-like behavior in female non-human primates.
Source: NatureCategories: Latest Headlines, NeurologyTweet-
Single-nucleus RNA-seq and spatial transcriptomic profiling the dlPFC of female macaques with #depressive-like behaviors identifies enrichment of a pro-inflammatory #microglia subpopulation in the depressive-like condition https://t.co/vsGwWlys9z
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Mashup Score: 4Local translation in microglial processes is required for efficient phagocytosis - Nature Neuroscience - 10 month(s) ago
Vasek et al. demonstrate that distal processes of microglia locally translate specific mRNAs including those related to immunity and phagocytosis. They then show that local protein synthesis is necessary for microglial process-initiated phagocytosis.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Study shows that the translation of #protein by #microglia supports efficient phagocytosis @NatureNeuro https://t.co/Pr5050iYje https://t.co/eoSvDaXgUk
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Mashup Score: 1Wolters Kluwer Health - 11 month(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, RheumatologyTweet-
Read an article in #PAIN about #microglia senescence related to #neuropathic pain–associated comorbidities in the spared #nerveinjurymodel. https://t.co/hSMJw8f3wn @kren27
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Read an article in #PAIN about #microglia senescence related to #neuropathic pain–associated comorbidities in the spared #nerveinjurymodel. https://t.co/fjpcw5JsHd
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Read an article in #PAIN about #microglia senescence related to #neuropathic pain–associated comorbidities in the spared #nerveinjurymodel. https://t.co/9q2JaVqqRQ
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Mashup Score: 0Traumatic Brain Injury Interferes with Immune System Cells’ Recycling Process in Brain Cells - 1 year(s) ago
In a new study published in the January issue of Autophagy, they found that after traumatic brain injury, the brain’s immune system cells’ internal recyclin
Source: www.newswise.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Traumatic #BrainInjury Interferes with Immune System Cells’ Recycling Process in Brain Cells https://t.co/3L73mTLXl4 #TBI #neuroinflammation #neurdegeneration #cognition Inhibition of #autophagy in #microglia and #macrophages exacerbates innate immune responses and worsens… https://t.co/bFUHZbaRsg https://t.co/6AQvk6Y6Rz
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Mashup Score: 10Cell Press: STAR Protocols - 1 year(s) ago
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Source: star-protocols.cell.comCategories: General Medicine News, Latest HeadlinesTweet-
Online in @STARProtocols: #Protocol from Dr. Sandra Siegert @SiegertLab @ISTAustria describing functional assessment of human iPSC-derived #microglia by #immunostaining, #phagocytosis, calcium activity, and inflammation assay: https://t.co/BFuwqfwgDS Videos included! https://t.co/MKMk2YFwfu
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Mashup Score: 0
17 Mar 2023 Here’s a tau twist that may take some adapting to. CD4+ and CD8+ T cells, yes, those mercurial executioners of the immune system, may be responsible for the neurodegeneration seen in Alzheimer’s disease and other tauopathies. That’s the scenario outlined by David Holtzman, Washington University, St. Louis, and colleagues in Nature on March 8. The scientists report that,…
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Neurodegeneration—It’s Not the Tangles, It’s the #TCells https://t.co/571GEFzpMZ #microglia #CD8+ #meninges #brain #parenchyma #immunity #PD1 #dementia #amyloid #tau #Aβ Activated immune cells drive neurodegeneration in an #Alzheimer’s model https://t.co/VUaJjzkPk7 Can #AD… https://t.co/UGZigewVsm https://t.co/3BL4qnK4CR
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Mashup Score: 0Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Microglia and #macrophages contribute to the development and maintenance of #sciatica in lumbar disc herniation: @PAINthejournal https://t.co/XEN7rr8hd8 #DRG #dorsalhorn "Targeting microglia and macrophages may be a promising treatment for chronic LDH-induced sciatica." https://t.co/DLZGXioqhm
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Mashup Score: 0Microglia-Mediated Astrocyte Activation in Chronic Pain - 1 year(s) ago
While acute pain is an important biological signal in response to injured tissue, chronic pain occurs when the pain signaling outlasts the initial injury and has deleterious effects on health and quality of life. Chronic pain represents an enormous public health burden with few therapeutic options.
Source: Wu Tsai Neurosciences InstituteCategories: Healthcare Professionals, Latest HeadlinesTweet-
“#Microglia-Mediated #Astrocyte Activation in #ChronicPain” https://t.co/ossbFyoEzu https://t.co/X3WqTMrfFA
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Mashup Score: 12
van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of #brain #microglia @NatureNeuro https://t.co/zfMw9Iu9zp https://t.co/os5U63AWgk
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Understanding the role of #microglia in Alzheimer's disease @NatureNeuro https://t.co/wxu8aOlv0e