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Mashup Score: 2Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study - Critical Care - 1 year(s) ago
Rationale Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients. Objectives We investigated whether steroid profiles before and after corticotropin stimulation can predict the risk of in-hospital death in sepsis. Methods An exploratory data analysis of a double blind, randomized trial…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 1
Background The combination therapy of hydrocortisone, vitamin C, and thiamine has been proposed as a potential treatment in patients with sepsis and septic shock. However, subsequent trials have reported conflicting results in relation to survival outcomes. Hence, we performed this randomized controlled trial (RCT) to evaluate the efficacy and safety of early combination therapy among adult…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Trialing early use of #hydrocortisone, #vitamin_C, and #thiamine in adult patients with #septic_shock. https://t.co/Bm7GJQt3bt @jlvincen @ISICEM #FOAMed #FOAMcc #sepsis https://t.co/hiXd2uIsIp
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Mashup Score: 3Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis - Critical Care - 2 year(s) ago
Background The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Methods Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case–control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess The #prognostic value of #Pentraxin3 on the #mortality of patients with #sepsis https://t.co/zCtXhoK659 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #PTX3 #infection #inflammation #septic_shock #prevention https://t.co/nUu09MkhCP
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Mashup Score: 1Personalized medicine in the ICU - 2 year(s) ago
Thematic Series After so many negative randomized, controlled trials, that have evaluated a number of simplified therapeutic interventions that could be applied to large patient populations, people are turning their interest back to personalized medicine.This new Thematic Series will share thoughts based on scientific data and help the clinician to individualize the…
Source: www.biomedcentral.comCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess TC: “#PERSONALIZED_MEDICINE IN THE #ICU” https://t.co/7fpW65xtlP @Vasopressin in #septic_shock: when starting? https://t.co/fO8WSAJMto @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #sepsis #norepinephrine #pharmacokinetics https://t.co/xgmI2Ce8Pm
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Mashup Score: 3A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation - Critical Care - 2 year(s) ago
Purpose Sepsis is a leading cause of morbidity and mortality worldwide and is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context of vascular leak. We therefore sought to quantify vascular leak in sepsis patients to guide fluid resuscitation. Methods We performed a retrospective cohort study of sepsis patients in four ICU…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Quantification of #vascular_leak in #sepsis patients to guide #fluid #resuscitation https://t.co/bvKcC6V5qM @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Hematocrit #Pharmacokinetics #Fluid_balance #Septic_shock https://t.co/rzszPJG5DG
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Mashup Score: 0
Background Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical outcomes is uncertain. Methods We performed a planned secondary analysis of a cluster-randomized trial conducted from July 2011 to May 2015 including forty German hospitals. All adult patients with sepsis treated in the participating ICUs were included….
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Delayed #antimicrobial treatment after onset of #sepsis is associated with poor outcome https://t.co/6TS6LpsAa4 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #septic_shock #mortality #Antibiotic #infection https://t.co/Wz1BCCZ05k
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Mashup Score: 2
Background Nighttime hospital admission is often associated with increased mortality risk in various diseases. This study investigated compliance rates with the Surviving Sepsis Campaign (SSC) 3-h bundle for daytime and nighttime emergency department (ED) admissions and the clinical impact of compliance on mortality in patients with septic shock. Methods We conducted an observational study using…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #Septic_shock patients admitted to the ED during the daytime exhibited lower #sepsis bundle compliance than those admitted at night https://t.co/zucoNTA98L @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #sepsis_campaign #hospital_admittance #emergency https://t.co/TOxtaWadDD
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Mashup Score: 2Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial - Critical Care - 2 year(s) ago
Background Intravenous vitamin C administration in septic shock may have a sparing effect on vasopressor requirements, and vitamin C’s enzyme cofactor functions provide a mechanistic rationale. Our study aimed to determine the effect of intravenous vitamin C administration on vasopressor requirements and other outcomes in patients with septic shock. Methods This was a double-blind, randomised…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Intravenous #VitaminC administration on #vasopressor requirements and #outcome in patients with #septic_shock https://t.co/iZHEAWuMuj @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #sepsis #ascorbic_acid #nutrition #infection #Noradrenaline https://t.co/GphUpXa7Zr
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Mashup Score: 5Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients - Critical Care - 2 year(s) ago
Background Vitamin C has potential protective effects through antioxidant and anti-inflammatory properties. However, the effect of vitamin C supplementation on microvascular function and peripheral tissue perfusion in human sepsis remains unknown. We aimed to determine vitamin C effect on microvascular endothelial dysfunction and peripheral tissue perfusion in septic shock patients. Methods…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #VitaminC #supplementation improved peripheral #tissue_perfusion and #microvascular reactivity in #septic_shock patients https://t.co/afA5iPj0Iz @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #sepsis #ascorbic_acid #nutrition #infection https://t.co/Xf7aNPryRa
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Mashup Score: 4The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis - Critical Care - 2 year(s) ago
Background Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic and prognostic biomarkers. Protein C’s role as an anticoagulant and anti-inflammatory molecule makes it an appealing target for sepsis biomarker studies. This meta-analysis aims to…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #Diagnostic and #prognostic value of #proteinC as a #biomarker for adult #sepsis https://t.co/JBapaiWwfG @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #inflammation #anticoagulant #septic_shock #infection #systematic_review https://t.co/jeUc5UJ2I4
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#CritCare #OpenAcess Predicting the risk of in-hospital death using corticotropin-stimulated #steroid profiles. https://t.co/CEhZsu4tLv @jlvincen @ISICEM #FOAMed #FOAMcc #sepsis #septic_shock #mortality #corticosterone #hydrocortisone https://t.co/B46UXAKVZl