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Mashup Score: 0Multiple tumours of different lineages likely related to a DNMT3A pathogenic R688H variant - 27 day(s) ago
Introduction The relationship between epigenetic modifications that influence gene regulation, such as histone deacetylation, microRNA regulation and DNA methylation, and human diseases has become increasingly recognised. Dysregulation of DNA methylation has been implicated in genomic imprinting and tumourigenesis. Previous studies identified several epigenetic modifier genes that directly cause genomic DNA (gDNA) methylation such as DNA methyltransferases ( DNMTs). DNMT aberrations usually affect genome-wide methylation profiles, deactivating many tumour suppressor genes by methylation of their promoters. In this study, we describe a unique case with several tumours of different lineages, likely caused by a germline pathogenic DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) variant.Methods We evaluated a middle-aged female who suffered from multiple metachronous and synchronous tumours, mostly benign, including subcutaneous lipomas and mesenchymal tumours, multinodular goitre, a
Source: connectionscgg.bmj.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 0Tumori, la radioterapia come cura delle metastasi: lo studio europeo con IRCCS di Negrar capofila - 2 year(s) ago
La ricerca “Oligocare” ha valutato l’impatto radicale della radioterapia su 1.600 pazienti, che presentavano da una a cinque metastasi, reclutati da 44 istituti di 12 Paesi europei
Source: VeronaSeraCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
EOTRC in the news: "#Tumours, #radiotherapy as a treatment for #metastases: the European study with the Negrar IRCCS as lead partner." Read article in Italian: https://t.co/vthEuwS0BS @alongi_filippo @ESTRO_RT @WBA_Global #Oligocare #CancerResearch #ClinicalTrials https://t.co/DlvSLb4fzO
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Mashup Score: 5
Multiple #rib resection as part of #chest wall resection requires a solid reconstruction to avoid flail chest & respiratory complications. Here ribs 2,3,4 we…
Source: YouTubeCategories: Latest Headlines, Oncologists2Tweet-
Reconstruction with #Titanium mesh is one among the major developments in resection of #chestwall #tumours in #thoracicsurgery https://t.co/EkiX3YWEPC via @YouTube
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Mashup Score: 1Browse | EDM Case Reports - 2 year(s) ago
Browse | EDM Case Reports
Source: EDM Case ReportsCategories: Endocrinology, Latest HeadlinesTweet-
Did you know we publish case reports on #NETS #neuroendocrine #tumours ? We’re at the #ENETS Conference in Vienna this week! Come by the Bioscientifica stand and chat with the publishing team or browse our case reports online: https://t.co/w9566p5LV1 https://t.co/9AGMUG5Bof
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Mashup Score: 0Multiparametric evaluation of bone tumors utilising diffusion weighted imaging and dynamic contrast enhanced magnetic resonance imaging - 2 year(s) ago
This study aimed to use multiparametric magnetic resonance imaging (MRI) techniques, namely, diffusion-weighted imaging (DWI) and dynamic contrast-enh…
Source: www.sciencedirect.comCategories: Latest Headlines, OrthopedicsTweet-
An interesting article on bone #tumours evaluation Multiparametric evaluation of bone tumors utilizing diffusion weighted imaging and dynamic contrast enhanced magnetic resonance imaging. https://t.co/hx100p8Lo5 @journal_trauma #JCOT #MRI https://t.co/EcckMpj0Vd
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Mashup Score: 1
This study provides evidence that right-sided hemicolectomy is not indicated after complete resection of an appendiceal NET of 1–2 cm in size by appendectomy, that regional lymph node metastases of appendiceal NETs are clinically irrelevant, and that an additional postoperative exclusion of metastases and histopathological evaluation of risk factors is not supported by the presented results….
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
ICYMI: in our latest issue, a retrospective, Europe-wide cohort study comparing hemicolectomy vs appendectomy for pts w/ appendiceal #neuroendocrine #tumours 1–2 cm in size https://t.co/uSmRMTd1xi
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Mashup Score: 0The Lancet Oncology - 2 year(s) ago
Access articles from The Lancet Oncology, covering topics that advance clinical practice, challenge the status quo, advocate change in health policy, and tackle issues related to global oncology
Source: www.thelancet.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our February issue is out now, with articles on #multiplemyeloma, #breastcancer and #malebreastcancer, #neuroendocrine #tumours, #thyroidcancer, #TMB, #global #radiotherapy & more. Read it here: https://t.co/tyRoZxwb4X https://t.co/4niERJl5SR
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Mashup Score: 1
A systematic literature search was conducted to compare the effectiveness of simultaneously performed portal and hepatic vein embolization (PVE/HVE) and PVE alo
Source: OUP AcademicCategories: Latest Headlines, SurgeryTweet-
#ICYMI In bilobar #liver #tumours, portal and hepatic vein embolisation seems to improve resectability vs portal vein alone, similar complication profile #some4surgery #some4hpb @asgbi @SEIQuirurgica https://t.co/sAc2F6uKvZ https://t.co/Ut6ienSrm7
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Mashup Score: 7
Selpercatinib showed clinically meaningful activity in the RET fusion-positive tumour-agnostic population, with a safety profile consistent with that observed in other indications. Comprehensive genomic testing that includes RET fusions will be crucial for identifying patients who might benefit from selpercatinib.
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
ICYMI – in our Oct issue: LIBRETTO-001 - Tumour-agnostic efficacy and safety of #selpercatinib in patients with RET fusion-positive solid #tumours other than lung or thyroid tumours: a phase 1/2, open-label, basket trial https://t.co/HAjMVZi26J
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Mashup Score: 5Nature Reviews Cancer - Volume 22 Issue 10, October 2022 - 3 year(s) ago
COVER: The perils of herbal remedies, inspired by the Review on p576.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our Oct issue, out NOW! With articles on aristolochic acid-associated cancers, NK cells in #immunotherapy, oncofetal reprogramming in #tumours. Plus a Viewpoint on #cancer nanomedicine & a #NRCToT on 3D imaging of human tumours! 💌 https://t.co/ZZ3dRK4N6i @natrescancer https://t.co/2Hl9FzIfVJ
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Recently published by BMJ Connections Clinical Genetics & Genomics: Multiple #tumours of different lineages likely related to a DNMT3A pathogenic R688H variant. Read it here: 👉 https://t.co/d2clEUwOLi https://t.co/nCOJgojeBr