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Mashup Score: 14Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition - 4 hour(s) ago
With an estimated 65 million individuals affected by post-COVID-19 condition (also known as long COVID),1 non-invasive biomarkers are direly needed to guide clinical management. To address this pressing need, we used blood transcriptomics in a general practice-based case-control study. Individuals with long COVID were diagnosed according to WHO criteria, and validated clinical scales were used to quantify patient-reported outcomes.2 Whole blood samples were collected from 48 individuals with long COVID and 12 control individuals matched for age, sex, time since acute COVID-19, severity, vaccination status, and comorbidities (appendix 1 p 2).
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease - 12 hour(s) ago
LRP-1 mediates the adverse effect of NAFLD on peripheral Aβ clearance, thereby contributing to cerebral Aβ accumulation and cognitive impairment in NAFLD.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2
Despite the substantial incidence of rSCC detected in the intervention group, the rate of cSCC in both groups was low at a median of 22 months of follow-up. Routine use of screening MRI and pre-emptive treatment to prevent cSCC is not warranted in patients with asymptomatic castration-resistant prostate cancer with spinal metastasis.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10Offline: It is time to take cancer more seriously - 15 hour(s) ago
The Lancet has published two Commissions in 2024 addressing the commonest cancers among men and women: prostate cancer (led by Nicholas James) and breast cancer (led by Charlotte Coles). As we were preparing these Commissions for publication, we considered writing an editorial linking the two cancers. But we hesitated. Surely these conditions are distinguished by their differences, not their similarities. Breast cancer is preventable. No such possibilities exist for prostate cancer. As our Commission on Prostate Cancer concluded: “The projected rise in prostate cancer cases cannot be prevented by lifestyle changes or public health interventions.” Yet, observing their launches and listening to the debates they provoked suggests that these cancers have more in common than might be appreciated—synergies that have important implications for accelerating cancer prevention and control.
Source: www.thelancet.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 0Earth Day: time for transformational change - 16 hour(s) ago
On April 22, the 54th annual Earth Day will continue endeavours to “diversify, educate and activate the environmental movement worldwide”. Part of Earth Day’s ongoing work includes broadening the definition of environmental issues to include the health of both individuals and communities. This year’s theme, Planet vs Plastics, which encapsulates one of many ways the environment shapes human health, hopes to galvanise businesses, governments, non-governmental organisations, and individuals to commit to call for the end of plastics.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 10Offline: It is time to take cancer more seriously - 19 hour(s) ago
The Lancet has published two Commissions in 2024 addressing the commonest cancers among men and women: prostate cancer (led by Nicholas James) and breast cancer (led by Charlotte Coles). As we were preparing these Commissions for publication, we considered writing an editorial linking the two cancers. But we hesitated. Surely these conditions are distinguished by their differences, not their similarities. Breast cancer is preventable. No such possibilities exist for prostate cancer. As our Commission on Prostate Cancer concluded: “The projected rise in prostate cancer cases cannot be prevented by lifestyle changes or public health interventions.” Yet, observing their launches and listening to the debates they provoked suggests that these cancers have more in common than might be appreciated—synergies that have important implications for accelerating cancer prevention and control.
Source: www.thelancet.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 50Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition - 19 hour(s) ago
With an estimated 65 million individuals affected by post-COVID-19 condition (also known as long COVID),1 non-invasive biomarkers are direly needed to guide clinical management. To address this pressing need, we used blood transcriptomics in a general practice-based case-control study. Individuals with long COVID were diagnosed according to WHO criteria, and validated clinical scales were used to quantify patient-reported outcomes.2 Whole blood samples were collected from 48 individuals with long COVID and 12 control individuals matched for age, sex, time since acute COVID-19, severity, vaccination status, and comorbidities (appendix 1 p 2).
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Responsible and evidence-based AI: 5 years on - 20 hour(s) ago
“The answer to our current health crisis is AI; AI is better than doctors and we should be using it now.”
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 50Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition - 21 hour(s) ago
With an estimated 65 million individuals affected by post-COVID-19 condition (also known as long COVID),1 non-invasive biomarkers are direly needed to guide clinical management. To address this pressing need, we used blood transcriptomics in a general practice-based case-control study. Individuals with long COVID were diagnosed according to WHO criteria, and validated clinical scales were used to quantify patient-reported outcomes.2 Whole blood samples were collected from 48 individuals with long COVID and 12 control individuals matched for age, sex, time since acute COVID-19, severity, vaccination status, and comorbidities (appendix 1 p 2).
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 46Endocrine health in survivors of adult-onset cancer - 21 hour(s) ago
Long-term survivors of cancer (ie, the patient who is considered cured or for whom the disease is under long-term control and unlikely to recur) are at an increased risk of developing endocrine complications such as hypothalamic–pituitary dysfunctions, hypogonadisms, osteoporosis, or metabolic disorders, particularly when intensive tumour-directed therapies are applied. Symptom severity associated with these conditions ranges from mild and subclinical to highly detrimental, affecting individual health and quality of life.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
NEW #LongCovid case-control (N=60) strongly suggests active viral replication & finds viral & immune parameters, incl antisense Orf1ab RNA conc & immunometab score, assoc w/ pt-reported symptoms. Antiviral #clinicaltrials are a priority IMO. #MedTwitter https://t.co/xTevlwZFsn