The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

Aging is accompanied by a disrupted information flow, which results from accumulation of molecular mistakes. These mistakes ultimately give rise to debilitating disorders such as skeletal muscle wasting, or sarcopenia. To estimate the growing ″disorderliness″ of the aging muscle system, we employed a statistical physics approach to estimate the state parameter, entropy, as a function of genes…