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Mashup Score: 21Paper of the Day - 3 hour(s) ago
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Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 0
Background Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact the response to angiotensin-II treatment during vasodilatory shock. Methods In a post-hoc subgroup analysis of the randomized, placebo-controlled, Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we compared patients with chronic angiotensin-converting enzyme inhibitor (ACEi) use, and patients with angiotensin receptor blocker (ARB) use, to patients without exposure to either ACEi or ARB. The primary outcome was mean arterial pressure after 1-h of treatment. Additional clinical outcomes included mean arterial pressure and norepinephrine equivalent dose requirements over time, and study-drug dose over time. Biological outcomes included baseline RAS biomarkers (renin, angiotensin-I, angiotensin-II, and angiotensin-I/angiotensin-II ratio), and the change in renin from 0 to
Source: ccforum.biomedcentral.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 3
ce risk of lethal clot formation, secondary mechanical circulatory support (MCS) devices are increasingly used despite limited understanding of their effects on cardiac function. This study sought to quantify the effects of VA-ECMO and combined with either intraaortic balloon pump (IABP) or percutaneous ventricular assist device (pVAD) on LV physiologic state and perfusion metrics in a porcine model of acute cardiogenic shock. Shock was induced through serial left anterior descending artery microbead embolization followed by initiation of VA-ECMO support and then placement of either IABP or pVAD. Hemodynamic measurements, LV pressure-volume loops, and carotid artery blood flow were evaluated before and after institution of combined MCS. The IABP decreased LV end-diastolic pressure by a peak of 15% while slightly increasing LV stroke work compared with decreases of more than 60% and 50% with the pVAD, respectively. The pVAD also demonstrated increased coronary perfusion and systemic pre
Source: journals.lww.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 11 hour(s) ago
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Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 12 hour(s) ago
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Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 13 hour(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 14 hour(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 15 hour(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 16 hour(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 36Journal Watch - 17 hour(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: General Medicine News, Critical CareTweet
Today's paper of the day is by @t1mo_m on fluids in the ICU: which is the right one? https://t.co/JKgcYjlUQ5 Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2023 https://t.co/eaWttRbpFV