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Mashup Score: 1Pumping Iron Burns Fat in Lung Injury - 8 hour(s) ago
Acute respiratory distress syndrome (ARDS) poses a significant clinical challenge, and the mainstay of treatment is primarily supportive (1). Corticosteroids have been tested in ARDS with variable results, and the full impact of their use as a generalized therapy in ARDS is debated (2). Broad immunosuppression in ARDS is not fully supported by our understanding of lung immunity. Indeed, inflammation is not ubiquitously harmful and is actually necessary for important biological functions such as host
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Mashup Score: 4Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 16 hour(s) ago
N6-methyladenosine (m6A) plays a role in various diseases, but it has rarely been reported in acute lung injury (ALI). The FTO (fat mass and obesity-associated) protein can regulate mRNA metabolism…
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Mashup Score: 11Climate Change - 16 hour(s) ago
The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is issuing a call for papers: βClimate Change: Cellular and Molecular Mechanisms Impacting Lung Pathobiology.β This call aims to showcase work that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease either directly, or through interaction with other elements (e.g., ozone, PM2.5, allergens, pathogens). The Journal welcomes Original Research, Perspectives, Major Technical
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Mashup Score: 2Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury - 23 hour(s) ago
The recent coronavirus disease (COVID-19) pandemic has highlighted the need for a greater understanding of the pathogenesis of acute respiratory distress syndrome (ARDS). ARDS is a lethal condition resulting from acute lung injury (ALI) caused by pulmonary insults, including viral infection, sepsis, aspiration, and trauma. ARDS is associated with alveolar damage, endothelial dysfunction, pulmonary edema, and immune infiltration and inflammation that lead to hypoxemic respiratory failure (1 β 3). Mortality
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Mashup Score: 4
The tight monolayer of the alveolar epithelium, which is essential for adequate gas exchange and innate immunity of the lung, is composed of alveolar epithelial type I (ATI) and ATII cells. Despite significant improvements in recent years, modeling the alveolar epithelial barrier in vitro remains a major challenge (1, 2). In an ideal scenario, a culture system that uses primary cells with maintained phenotype and function over extended periods and of human origin would be necessary. Unfortunately,
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Mashup Score: 2ATS Conference 2024 - Learning Studios - 3 day(s) ago
American Thoracic Society
Source: conference.thoracic.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 4Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 5 day(s) ago
The role of alternative splicing in chronic obstructive pulmonary disease (COPD) is still largely unknown. We aimed to investigate the differences in alternatively splicing events between patients …
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Mashup Score: 2ATS Conference 2024 - Learning Studios - 8 day(s) ago
American Thoracic Society
Source: conference.thoracic.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2ATS Conference 2024 - Learning Studios - 8 day(s) ago
American Thoracic Society
Source: conference.thoracic.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction - 8 day(s) ago
Intrauterine growth restriction (IUGR) is characterized by fetal weight below the 10th percentile per gestational age, increased risk for various conditions, and premature death (1). Infants with IUGR are at an increased risk of the development of pulmonary hypertension (PH), a devastating condition characterized by increased pulmonary artery pressures and remodeling of the pulmonary vasculature (1). Among the potential causes of IUGR-associated PH is the arrested development of the pulmonary vascular
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