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Mashup Score: 535Metformin: update on mechanisms of action and repurposing potential - 11 hour(s) ago
Nature Reviews Endocrinology – This Review highlights the latest advances in our understanding of the mechanisms of action of metformin. Potential repurposing of metformin for other indications is…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Pernicious anaemia - 5 day(s) ago
### What you need to know A 55 year old woman presents to her GP with fatigue, “pins and needles” sensation in her feet, and poor concentration. Clinical examination and routine blood investigations were unremarkable. Her symptoms gradually worsened over two years. She also developed exertional dyspnoea and unsteadiness while walking. On examination, she had pallor, resting tachycardia, and sensory neuropathy in both legs. A peripheral blood smear revealed macrocytic anaemia and hypersegmented neutrophils. Further investigations confirmed severe B12 deficiency secondary to pernicious anaemia. Pernicious anaemia is an autoimmune disorder affecting the gastric mucosa with impaired absorption of dietary cobalamin (vitamin B12) resulting in B12 deficiency. Figure 1 depicts the pathophysiology of pernicious anaemia. Vitamin B12 is essential for production of blood cells and myelination of nerves. Its deficiency causes megaloblastic anaemia. Neuronal demyelination and subsequent degeneration
Source: www.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Pernicious anaemia - 7 day(s) ago
### What you need to know A 55 year old woman presents to her GP with fatigue, “pins and needles” sensation in her feet, and poor concentration. Clinical examination and routine blood investigations were unremarkable. Her symptoms gradually worsened over two years. She also developed exertional dyspnoea and unsteadiness while walking. On examination, she had pallor, resting tachycardia, and sensory neuropathy in both legs. A peripheral blood smear revealed macrocytic anaemia and hypersegmented neutrophils. Further investigations confirmed severe B12 deficiency secondary to pernicious anaemia. Pernicious anaemia is an autoimmune disorder affecting the gastric mucosa with impaired absorption of dietary cobalamin (vitamin B12) resulting in B12 deficiency. Figure 1 depicts the pathophysiology of pernicious anaemia. Vitamin B12 is essential for production of blood cells and myelination of nerves. Its deficiency causes megaloblastic anaemia. Neuronal demyelination and subsequent degeneration
Source: www.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Mauricio Ambriz (@mauambriz) • Instagram photos and videos - 9 day(s) ago
8,971 Followers, 823 Following, 40 Posts – See Instagram photos and videos from Mauricio Ambriz (@mauambriz)
Source: www.instagram.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 461
Cardiogenic shock (CS) is characterized by low cardiac output and sustained tissue hypoperfusion that may result in end-organ dysfunction and death. CS is associated with high short-term mortality, and its management remains challenging despite recent advances in therapeutic options. Timely diagnosis and multidisciplinary team-based management have demonstrated favourable effects on outcomes. We aimed to review evidence-based practices for managing patients with ischemic and non-ischemic CS, detailing the multi-organ supports needed in this critically ill patient population.
Categories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2068The Neurologic Exam - 14 day(s) ago
For most of human history, diseases preying upon the nervous system could only be identified indirectly through neurological signs—making the neurolog…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Mauricio Ambriz (@mauambriz) • Instagram photos and videos - 15 day(s) ago
8,971 Followers, 823 Following, 40 Posts – See Instagram photos and videos from Mauricio Ambriz (@mauambriz)
Source: www.instagram.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 83
Nature Reviews Nephrology – Here, the authors review techniques for cardiovascular diagnosis, screening and monitoring in patients with CKD, including approaches to the diagnosis of cardiac…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 15Mauricio Ambriz (@mauambriz) • Instagram photos and videos - 18 day(s) ago
8,971 Followers, 823 Following, 40 Posts – See Instagram photos and videos from Mauricio Ambriz (@mauambriz)
Source: www.instagram.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Diagnosis and management of Guillain–Barré syndrome in ten steps - 18 day(s) ago
Nature Reviews Neurology – In this Consensus Statement, Leonhard et al. provide a globally applicable guideline for the diagnosis and management of Guillain–Barré syndrome, including…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
Efectos antiinflamatorios e inmunomoduladores de la METFORMINA: Nat Rev Endocrinol 2023; DOI: https://t.co/YqmlGMnZMu https://t.co/uY4F3LcFjw