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Mashup Score: 73Indexing All Life's Known Biological Sequences - 5 day(s) ago
The amount of biological sequencing data available in public repositories is growing exponentially, forming an invaluable biomedical research resource. Yet, making it full-text searchable and easily accessible to researchers in life and data science is an unsolved problem. In this work, we take advantage of recently developed, very efficient data structures and algorithms for representing sequence sets. We make Petabases of DNA sequences across all clades of life, including viruses, bacteria, fungi, plants, animals, and humans, fully searchable and make the indexes available to the research community. The indexes are a highly compressed representation of the input sequences (up to 5800 fold) and fit on a single consumer hard drive (~$100). We present the underlying methodological framework, called MetaGraph, that allows us to scalably index very large sets of DNA or protein sequences using annotated De Bruijn graphs. We demonstrate the feasibility of indexing the full extent of existin
Source: www.biorxiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 6406Lucknerhaus - Blick zum Großglockner - Foto-Webcam.eu - 10 day(s) ago
Webcam Lucknerhaus – Blick zum Großglockner
Source: www.foto-webcam.euCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 31De novo gene synthesis by an antiviral reverse transcriptase - 11 day(s) ago
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this immune strategy by instead leveraging DNA synthesis, but the identities and functions of their DNA products remain largely unknown. Here we show that DRT2 systems execute an unprecedented immunity mechanism that involves de novo gene synthesis via rolling-circle reverse transcription of a non-coding RNA (ncRNA). Unbiased profiling of RT-associated RNA and DNA ligands in DRT2-expressing cells revealed that reverse transcription generates concatenated cDNA repeats through programmed template jumping on the ncRNA. The presence of phage then triggers second-strand cDNA synthesis, leading to the production of long double-stranded DNA. Remarkably, this DNA product is efficiently transcribed, generating messenger RNAs that encode a stop codon-less, never-ending ORF (
Source: www.biorxiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 47HUPD Chief Says Harvard Yard Encampment is Peaceful, Defends Students’ Right to Protest | News | The Harvard Crimson - 22 day(s) ago
HUPD Chief Says Harvard Yard Encampment is Peaceful, Defends Students’ Right to Protest | News | The Harvard Crimson
Source: www.thecrimson.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 7Phage predation, disease severity, and pathogen genetic diversity in cholera patients - 1 month(s) ago
Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)–bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, …
Source: www.science.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 9Salamander Story - 2 month(s) ago
The following article is based on a number or reference sources, both historical and speculative, including internet references, academic reviews, scholarly publications, and publications of professional associations. The article is not intended to present a fully accurate summation of how the salamander came to be used as the central focus of our union’s official logo. In fact, the full story may never be known as the original creators of our symbol left no record of their reasoning or intentions. We
Source: www.insulators.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 132The Molecular Architecture of the Nuclear Basket - 2 month(s) ago
The nuclear pore complex (NPC) is the sole mediator of nucleocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit considerable variation within and between species. One such structure is the cage-like nuclear basket. Despite its crucial roles in mRNA surveillance and chromatin organization, an architectural understanding has remained elusive. Using in-cell cryo-electron tomography and subtomogram analysis, we explored the NPC’s structural variations and the nuclear basket across fungi (yeast; S. cerevisiae), mammals (mouse; M. musculus), and protozoa (T. gondii). Using integrative structural modeling, we computed a model of the basket in yeast and mammals that revealed how a hub of Nups in the nuclear ring binds to basket-forming Mlp/Tpr proteins: the coiled-coil domains of Mlp/Tpr form the struts of the basket, while their unstructured termini constitute the basket distal densities, which potentially serve a
Source: www.biorxiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 4Bird by Bird - 2 month(s) ago
“Thirty years ago my older brother, who was ten years old at the time, was trying to get a report on birds written that he’d had three months to write. It was due the next day. …
Source: www.google.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 68NSURP.org - 2 month(s) ago
National Summer Undergraduate Research Project
Source: NSURP.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 22Business Cards - 2 month(s) ago
Business cards created for Harvard Medical School have special dedicated areas for information. Only the HMS primary logo is used for all business cards. Department or office locked up logos are not used on the business card and should not be used on official HMS business cards. Instead, the name of the office or department should be featured between the person’s title and office address. Underneath the logo features the person’s name, title, office address and office phone number.
Source: identityguide.hms.harvard.eduCategories: General Medicine News, Infectious DiseaseTweet
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