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    Register for Cleveland Clinic Biologic Therapies Summit. May 11-13, 2023 Cleveland, OH and learn how to optimize youruse of biologic therapies

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    • Don’t miss Cleveland Clinic’s Biologic Therapies Summit X & Vasculitis 2023: Advances in Immune Based Therapies: Balancing risks & benefits across the rheumatic diseases. Register today: https://t.co/ORAtKcuRoY @LCalabreseDO @ElaineHusniMD @AdamJBrownMD @ELittlejohnDO

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    Abstract Objectives: Immunocompromised patients with immune mediated inflammatory diseases (IMIDs), undergoing therapy with B cell depleting agents are among the most vulnerable to experience severe COVID-19 disease as well as respond sub-optimally to SARS CoV-2 vaccines yet little is known about the frequency or severity of breakthrough infection in this population. We have analyzed a large…

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    • Check it out! Important observations on plight of B cell depleted patients w/breakthrough COVID and efficacy of mAbs for Tx ⁦@LCalabreseDO⁩ ⁦@BetsyKirch⁩ ⁦@jeffsparks⁩ ⁦@zach_wallace_md⁩ ⁦@alhkim⁩ ⁦⁦@adarsh_bhimraj⁩ https://t.co/qg77uUSC0Q

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    This program will bring together a multidisciplinary group of clinicians to share expertise and improve the care of patients receiving immune checkpoint inhibitor therapies.

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    • 33 days left to register! 1 high yield day of virtual learning & multidisciplinary discussion on what’s hot in irAEs- “see” you there! @FunchainMD @Pradnya_PatilMD @JessPhilpottMD @JungSongCNS https://t.co/LnZ6Hc0C2u https://t.co/pia8K8kqlZ

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    In previously unvaccinated and uninfected individuals, non-RBD SARS-CoV-2 spike specific B cells were prominent in two distinct, durable, resting, cross-reactive, preexisting switched memory B cell compartments. While pre-existing RBD-specific B cells were extremely rare in uninfected and unvaccinated individuals, these two preexisting switched memory B cell compartments were molded by…

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    • Thought-provoking #covid work by my friend Cory Perugino! -large portion of vaccine induced B cells maintain ability to recognize omicron -Vaccine boosts preferentially enhance B cells w/highest affinity for wild type spike ⁦@LCalabreseDO⁩ ⁦ https://t.co/wVa0pVgvbo

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    Source/Disclosures Published by: Disclosures: Calabrese reports consulting fees from AbbVie, Amgen, Bristol Myers Squibb, Crescendo, Genentech, Gilead, GlaxoSmithKline, Horizon, Janssen, Kiniksa, Eli…

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    • @philipcrobinson @LCalabreseDO @CarlosdelRio7 @alhkim @jeffsparks @zach_wallace_md @hausmannMD https://t.co/suouadkAQ4

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    To date, more than 350 children have died from COVID-19 in the United States and with schools opening, we could be in for a lot of trouble in pediatric ICU units. I’m surprised our own major hospitals have not adequately prepared for this by assuring protection of their staff and their patients by immunization, writes Dr. Michael M. Lederman, Professor (emeritus) of Medicine,…

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    • Why are Cleveland’s major hospital systems not requiring staff involved in patient care to get vaccinated? good question @mmlederman1⁩ Time to man up, ⁦@ClevelandClinic⁩ Protect each other, kids, grandma, immunocompromised ⁦@LCalabreseDO⁩ https://t.co/NfYZoSiepq

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    Immunocompromised individuals have a number of justifiable concerns surrounding COVID-19. One of those concerns is that a two-dose vaccine schedule may not produce a sufficient antibody response to protect them from the virus. But hope may be on the horizon. On July 12, Israel’s Ministry of Health began offering a third dose of the Pfizer vaccine to severely immunocompromised adults. This

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    • Booster or not, immunocompromised patients must continue to be cautious after #covidvaccine amidst delta 😷 ⁦@GoHealio⁩ ⁦@LCalabreseDO⁩ ⁦@HealioRheum⁩ https://t.co/1SRJIPifYM