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Mashup Score: 36Outcomes in studies regarding older patients with prostate cancer: A systematic review - 15 day(s) ago
Older patients are often deemed ineligible for clinical research, and many frequently-used endpoints and outcome measures are not as relevant for older patients for younger ones. This systematic review aimed to present an overview of outcomes used in clinical research regarding patients over the age of 65 years with prostate cancer.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 18
Older patients are often excluded from clinical trials with the majority of patients being between the ages of 18 and 64 [1]. This may be due to increased incidence of medical comorbidities in the older adults as well as poorer performance status, but often this is a result of clinical selection bias for suitability for clinical trials [1,2]. Early phase clinical trials (EPCTs) aim to assess the tolerability and toxicity profile of novel anti-cancer therapeutics. The primary goal is to determine dose limiting toxicity (DLT) in order to move forward within the drug development timeline.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 7Trends in wearable device use among cancer survivors in the United States from 2019 to 2022 - 2 month(s) ago
The increasing digitization of healthcare has driven the rise in wearable devices, notably during the COVID-19 pandemic. Wearable devices continuously track patients’ physiological measurements, such as heart rate, activity, sleep, etc. For patients with cancer, these digital biomarkers may reflect meaningful variation in physical function, symptom burden, quality of life, and risk of adverse events, [1] and have the potential to improve physical activity and quality of life. [2] Despite the growing popularity and recognized benefits of wearable devices, research suggests a low uptake and digital divide in both healthy adults [3] and those with chronic diseases (e.g., cardiovascular disease) [4].
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 19
Acute myeloid leukemia (AML) is a disease of aging. Outcomes for older adults are poor, and a substantial proportion do not receive cancer-directed treatment [1–4]. Older adults with AML find treatment decisions overwhelming due to the sudden nature of the disease, lack of disease understanding, confusion about their treatment options, and inadequate communication from their oncology care provider [5]. Comorbid medical conditions and poor performance status are associated with treatment tolerability, and considering patient characteristics may help inform selection of appropriate treatments [6,7].
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet-
Patient-oncologist discussion of treatment decisions: Exploring the role of a patient-centered communication tool for older adults with acute myeloid leukemia and their caregivers https://t.co/Ee7ldfMxx3 @BattagliaJensen @MarissaLocastro @MelissaLoh21 @WilliamDale_MD @rochgerionc https://t.co/K9646BHtIO
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Mashup Score: 22Protocol for a randomized controlled trial of brief behavioral activation among older adult cancer survivors - 3 month(s) ago
As many as 35% of older adult cancer survivors (OACS; i.e., ≥65 years old) have clinically significant depression. OACS often experience fatigue, mild cognitive impairment, and increased medical comorbidities post-cancer that make them susceptible to depression. Behavioral activation (BA) is an empirically supported depression treatment in geriatric psychiatry that guides individuals to reengage in pleasurable and rewarding activities and has great potential for addressing the needs of OACS. This manuscript presents the protocol for a pilot randomized controlled trial (RCT) testing the efficacy of a brief BA intervention adapted to address the needs of OACS (BBA-OACS) by telephone and videoconference delivery.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 44Decreasing polypharmacy in older adults with cancer: A pilot cluster-randomized trial protocol - 3 month(s) ago
Polypharmacy is prevalent in older adults with cancer and associated with multiple adverse outcomes. A single-site, cluster-randomized clinical trial will enroll older adults with cancer and polypharmacy starting chemotherapy and will assess the effectiveness and feasibility of deprescribing interventions by comparing two arms: a pharmacist-led deprescribing intervention and a patient educational brochure.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 44Decreasing polypharmacy in older adults with cancer: A pilot cluster-randomized trial protocol - 3 month(s) ago
Polypharmacy is prevalent in older adults with cancer and associated with multiple adverse outcomes. A single-site, cluster-randomized clinical trial will enroll older adults with cancer and polypharmacy starting chemotherapy and will assess the effectiveness and feasibility of deprescribing interventions by comparing two arms: a pharmacist-led deprescribing intervention and a patient educational brochure.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 33Impact of age, comorbidity, and polypharmacy on receipt of systemic therapy in advanced cancers: A retrospective population-based study - 3 month(s) ago
Cancer incidence, comorbidity, and polypharmacy increase with age, but the interplay between these factors on receipt of systemic therapy (ST) in advanced cancer has rarely been studied.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 16Association of depression with all-cause and cancer-specific mortality in older adults with cancer: Systematic review, meta-analysis, and meta-regression - 3 month(s) ago
The incidence and mortality of cancer is increasing worldwide with studies reporting that cumulative risk of cancer rises as age increases. Against the backdrop of the increasing prevalence of cancer amongst older patients, we conducted a systematic review and meta-analysis examining the depression-mortality relationship in older adults with cancer (OAC).
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet-
Association of depression with all-cause and cancer-specific mortality in older adults with cancer: Systematic review, meta-analysis, and meta-regression https://t.co/BafTBlRMGe @WilliamDale_MD @rochgerionc @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Depression https://t.co/51inkIhljD
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Mashup Score: 8The functional trajectories of older women having surgery for gynaeoncology cancer: A single site prospective observational study - 3 month(s) ago
Population aging longevity and advances in robotic surgery suggest that increasing numbers of older women having gynaeoncological surgery is likely. Postoperative morbidity and mortality are more common in older than younger women with the age-associated characteristics of multimorbidity and frailty being generally predictive of worse outcome. Priorities that inform treatment decisions change during the life course: older patients often place greater’ value on quality-of-life-years gained than on life expectancy following cancer treatments.
Source: www.geriatriconcology.netCategories: General Medicine News, Onc News and JournalsTweet
Outcomes in studies regarding older patients with prostate cancer: A systematic review https://t.co/3x6ETNdbSn @WilliamDale_MD @rochgerionc @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #ProstateCancer #OlderPatients #StudyOutcomes https://t.co/IkbBtnWFNo