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Mashup Score: 8
The role of the healthcare environment in the transmission of clinical pathogens is well established. We investigated the chemical stability and sporicidal efficacy of oxidising disinfectant products in the presence of simulated clean and medical dirty conditions.Performance of chlorine-releasing agents (sodium dichloroisocyanurate, chlorine dioxide and hypochlorous acid) was concentration-dependent, with 1000 ppm chlorine showing reduced stability and efficacy in dirty conditions. In contrast peracetic acid product demonstrated stability and consistently achieved efficacy in dirty conditions.
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Mashup Score: 7Qualitative research methods: Powerful tools for understanding practice and informing change - 2 day(s) ago
We currently exist in an era of unprecedented and increasing data. This era of data proliferation is particularly acute for health and medicine, which, as critical aspects of social funding, are saturated with knowledge. Yet much of the data produced is not actually utilised in service of better care. With the rise of AI, our ability to access information generated globally and examine large sets of data has never been greater. However, data volume versus data depth has become an emerging problem, and so too has the local relevance and authenticity of data.
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Mashup Score: 3
Healthcare associated infections (HAI) remain a global health challenge and have elevated rates in Sub-Saharan Africa. HAIs impact patients and their families by causing illness, prolonged hospital stay, potential disability, excess costs and sometimes death. The costs of HAI are increasing due to spreading antimicrobial resistance. A major risk factor for HAIs is lack of water, sanitation, and hygiene (WASH), environmental cleaning and healthcare waste management. In Sub-Saharan Africa these services are lacking in at least 50% of healthcare facilities.
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Mashup Score: 7ML-based risk assessment tool to rule out empiric use of ESBL-targeted therapy in endemic areas - 4 day(s) ago
Antimicrobial stewardship focuses on identifying patients who require ESBL-targeted therapy. Rule-in tools have been extensively researched in areas of low endemicity; however, such tools are inadequate for areas with high rates of ESBL, as almost all patients will be selected.
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Mashup Score: 6
The first British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS)-endorsed faecal microbiota transplant (FMT) guidelines were published in 2018. Over the past 5 years, there has been considerable growth in the evidence base (including publication of outcomes from large national FMT registries), necessitating an updated critical review of the literature and a second edition of the BSG/HIS FMT guidelines. These have been produced in accordance with National Institute for Health and Care Excellence-accredited methodology, thus have particular relevance for UK-based clinicians, but are intended to be of pertinence internationally.
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Mashup Score: 8
Many Gram -negative bacteria other than Pseudomonas aeruginosa have been implicated in waterborne outbreaks but standardised laboratory detection methods for these organisms have not been established.
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Mashup Score: 3Short Versus Prolonged Duration of Therapy for Pseudomonas aeruginosa Bacteremia: A Systematic Review and Meta-analysis - 8 day(s) ago
The optimal duration of therapy for Pseudomonas aeruginosa bloodstream infection (PSA-BSI) is unknown, with prolonged therapy frequently favored due to severity of infection, patient complexity, risk of multi-drug resistance, and high mortality. We therefore conducted a systematic review and meta-analysis of studies with head-to-head comparison of short versus prolonged therapy for PSA-BSI.
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Mashup Score: 9
Contamination of wastewater systems in healthcare settings with multidrug-resistant organisms (MDROs) represents a significant challenge to healthcare providers. In the past decade there has been increased attention paid to reservoirs of contamination in healthcare wastewater systems, with a particular emphasis on sinks and shower drains. Gram-negative MDROs including Pseudomonas aeruginosa, Acinetobacter baumaunii and carbapenemase-producing Enterobacterales (CPE) have been isolated from wastewater systems and have been directly linked to outbreaks and healthcare-associated infections (HCAIs) in patients1.
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Mashup Score: 14Which antiseptic to use for a Caesarean section? A systematic review and network meta-analysis of randomised controlled trials - 10 day(s) ago
Guidelines for preoperative skin antisepsis recommend using chlorhexidine in an alcohol-based solution. However, other antiseptics such as aqueous povidone iodine or alcohol-based solutions are still used. Randomised controlled trials (RCTs) in Caesarean section (CS) are rare and do not include all possible comparisons of antiseptics.
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Mashup Score: 53
The World Health Organization’s (WHO) World Hand Hygiene Day continues to ‘bring people together and accelerate hand hygiene action at the point of care in health care to contribute to a reduction in healthcare-associated infections and the achievement of safer, quality health care for all’.
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🧴New study tests chemical stability and sporicidal efficacy of oxidising disinfectant products in simulated clean and dirty conditions 💧Performance of chlorine-releasing agents was concentration-dependent, with 1000 ppm chlorine showing reduced efficacy https://t.co/NDsfmJ4Rby