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    An adolescent boy with a history of perianal abscess and anal fistula presented to the gastroenterology department complaining of intermittent abdominal pain and diarrhea for 1 year. Physical examination showed no abnormalities. Colonoscopy revealed deep fissuring ulcers and friability from ileocecal junction to splenic flexure, suggesting a diagnosis of Crohn disease (Figure A). He suffered from a fever (temperature peaked at 38.5 °C) without abdominal pain after colonoscopy. Laboratory examination showed white blood cell counts up to 20.5 × 109/L.

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    • Medical image: The pathogenesis of hepatic portal venous gas is gastrointestinal mucosal injury and elevated intraluminal pressure leading to gas drainage into the portal vein system through the intestinal wall. https://t.co/7stirPFb4e https://t.co/V4K0amIsO5

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    Shelley S. Noland, MD, is a board-certified hand and peripheral nerve surgeon who provides comprehensive hand, wrist, and peripheral nerve surgical care. She also is an Associate Professor of Plastic Surgery, Mayo Clinic College of Medicine and Science. Dr Noland serves as the Medical Director of the Multidisciplinary Peripheral Nerve Clinic, and Medical Director of the Center for Humanities in Medicine at Mayo Clinic in Arizona. Dr Noland attended medical school at Chicago Medical School. She completed

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    • Mayo Clinic Proceedings editorial board member Shelly S. Noland, MD, a hand and peripheral nerve surgeon at Mayo Clinic, brings expertise for Humanities in Medicine, the Compass. https://t.co/Z0ZqiX5uXG https://t.co/ivTvQ6ng03

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    Autosomal dominant polycystic kidney disease (ADPKD), the most prevalent genetic kidney disorder, is characterized by diffuse kidney cysts, hypertension, and progressive kidney function decline, often leading to kidney failure by the age of 60 years. Compared with the general population, patients with ADPKD have an increased risk for development of saccular intracranial aneurysms (IAs), which can lead to intracranial bleeding and result in significant disability and mortality. Of both modifiable and nonmodifiable risk factors, the most significant is a family history of IAs or aneurysm rupture.

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    • Patients with autosomal dominant polycystic kidney disease have a higher prevalence of Intracranial aneurysms, which poses a significant clinical challenge because of their potential for severe neurologic outcomes. https://t.co/aH49y1ZyTI https://t.co/ITeNv8ajTl

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    To compare dialysis transition patterns of chronic kidney disease (CKD) patients with heart failure (HF) and without HF, including inpatient “crash start” initiation of long-term (“maintenance”) dialysis, early dialysis initiation as evaluated by estimated glomerular filtration rate (eGFR), and rate of central venous catheter (CVC) use for hemodialysis.

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    • These findings demonstrate patients with chronic kidney disease and heart failure are more likely to initiate maintenance dialysis in contexts associated with greater resource expenditure and risk of suboptimal outcomes. https://t.co/FIewoLYPdC https://t.co/xlwrdLYxLh

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    An adolescent boy with a history of perianal abscess and anal fistula presented to the gastroenterology department complaining of intermittent abdominal pain and diarrhea for 1 year. Physical examination showed no abnormalities. Colonoscopy revealed deep fissuring ulcers and friability from ileocecal junction to splenic flexure, suggesting a diagnosis of Crohn disease (Figure A). He suffered from a fever (temperature peaked at 38.5 °C) without abdominal pain after colonoscopy. Laboratory examination showed white blood cell counts up to 20.5 × 109/L.

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    • Medical image: The pathogenesis of hepatic portal venous gas is gastrointestinal mucosal injury and elevated intraluminal pressure leading to gas drainage into the portal vein system through the intestinal wall. https://t.co/KVDOZdzcuC https://t.co/5VnlUH6AkG

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    Obesity is a chronic complex disease with deleterious effects on multiple organs and systems through a process called lipotoxicity. Obesity is commonly associated with a range of systemic comorbidities, including cardiovascular diseases, obstructive sleep apnea, type 2 diabetes mellitus, dyslipidemia, osteoarthritis, and depression. Unfortunately, these conditions can be overlooked in the clinical setting, yet early detection and intervention of obesity-related comorbidities can lead to significantly improved health outcomes and well-being.

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    • Clinical Assessment of People With Obesity: Focus on Adiposity-Related Multimorbidity - Mayo Clinic Proceedings https://t.co/cBIZiwSmY3