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Mashup Score: 22Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer - 22 hour(s) ago
Androgen receptor signaling is crucial for the development of treatment resistance in prostate cancer. Among steroidogenic enzymes, 3β-hydroxysteroid dehydrogenases (3βHSDs) play critical roles in extragonadal androgen synthesis, especially 3βHSD1. Increased expression of 3βHSDs is observed in castration-resistant prostate cancer tumors compared with primary prostate tumors, indicating their involvement in castration resistance. Recent studies link 3βHSD1 to resistance to androgen receptor signaling inhibitors. The regulation of 3βHSD1 expression involves various factors, including transcription factors, microenvironmental influences, and post-transcriptional modifications. Additionally, the clinical significance of HSD3B1 genotypes, particularly the rs1047303 variant has been extensively studied. The impact of HSD3B1 genotypes on treatment outcomes varies according to the therapy administered, suggesting the potential of HSD3B1 genotyping for personalized medicine. Targeting 3βHSDs ma
Source: erc.bioscientifica.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 15
Alicia Morgans and Nima Sharifi discuss the role of the HSD3B1 gene and its variants in prostate cancer. Dr. Sharifi explains that the adrenal permissive allele of HSD3B1 is common in people of European ancestry and is associated with increased conversion of adrenal androgen precursors to potent androgens like DHT. This allele is linked to faster progression and higher prostate cancer-specific…
Source: www.urotoday.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Opinion | The Nobel Prize-Winning Professor Who Liked to Collaborate With His Adversaries (Gift Article) - 1 month(s) ago
The Nobel Prize winner Daniel Kahneman insisted on the value of working with those we disagree with.
Source: www.nytimes.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Joan Manuel Serrat - Mediterráneo (1971) - 1 month(s) ago
© 2022. Producido por Zafiro/Novola en el año de 1971.Joan Manuel Serrat – Mediterráneo (1971)#joanmanuelserrat #Medierráneo #WMMusicRecordsLetra:Quizás porq…
Source: www.youtube.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
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Source: eju.tvCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10
The adrenal androgen-metabolizing 3β-hydroxysteroid dehydrogenase-1 enzyme, encoded by the HSD3B1 gene, catalyzes the rate-limiting step necessary for synthesizing nontesticular testosterone and dihydrotestosterone production.
Source: www.urotoday.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 26Mutation Linked to Increased Risk of Prostate Cancer Mortality - 1 month(s) ago
Cancer-specific mortality twice as high in patients with specific genotype for HSD3B1 allele
Source: www.medpagetoday.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Adrenal-Permissive HSD3B1 Allele and Prostate Cancer Outcomes - 1 month(s) ago
This cohort study analyzes the association of HSD3B1 status with prostate cancer outcomes among patients in the Veterans Affairs Health System in the US.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 37Adrenal-Permissive HSD3B1 Genotype and Prostate Cancer Mortality - 1 month(s) ago
Prostate cancer progression is dependent on androgen receptor signaling, which is activated by the circulating gonadal androgen testosterone and its more potent metabolite, 5α-dihydrotestosterone (DHT), generated from testosterone in the prostate. Androgen deprivation therapy (ADT) leading to the…
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
Diverse data from the Million Veteran Program has already contributed to hundreds of medical studies, and the V.A. is continuing to recruit more participants.
Source: www.nytimes.comCategories: General Medicine News, Hem/OncsTweet
Interesting review on 3βHSD1 in prostate cancer just out from the group in Kyushu @Endocancer @Soc_Endo. Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer https://t.co/BkEsvUXLYu