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Mashup Score: 8
Fibroblast activation protein-α (FAP) is often highly expressed by sarcoma cells and by sarcoma-associated fibroblasts in the tumor microenvironment. This makes it a promising target for imaging and therapy. The level of FAP expression and the diagnostic value of 68Ga-FAP inhibitor (FAPI) PET for sarcoma subtypes are unknown. We assessed the diagnostic performance and accuracy of 68Ga-FAPI PET in various bone and soft-tissue sarcomas. Potential eligibility for FAP-targeted radiopharmaceutical therapy (FAP-RPT) was evaluated. Methods: This prospective observational trial enrolled 200 patients with bone and soft-tissue sarcoma who underwent 68Ga-FAPI PET/CT and 18F-FDG PET/CT (186/200, or 93%) for staging or restaging. The number of lesions detected and the uptake (SUVmax) of the primary tumor, lymph nodes, and visceral and bone metastases were analyzed. The Wilcoxon test was used for semiquantitative assessment. The association of 68Ga-FAPI uptake intensity, histopathologic grade, and F
Source: jnm.snmjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 8
Fibroblast activation protein-α (FAP) is often highly expressed by sarcoma cells and by sarcoma-associated fibroblasts in the tumor microenvironment. This makes it a promising target for imaging and therapy. The level of FAP expression and the diagnostic value of 68Ga-FAP inhibitor (FAPI) PET for sarcoma subtypes are unknown. We assessed the diagnostic performance and accuracy of 68Ga-FAPI PET in various bone and soft-tissue sarcomas. Potential eligibility for FAP-targeted radiopharmaceutical therapy (FAP-RPT) was evaluated. Methods: This prospective observational trial enrolled 200 patients with bone and soft-tissue sarcoma who underwent 68Ga-FAPI PET/CT and 18F-FDG PET/CT (186/200, or 93%) for staging or restaging. The number of lesions detected and the uptake (SUVmax) of the primary tumor, lymph nodes, and visceral and bone metastases were analyzed. The Wilcoxon test was used for semiquantitative assessment. The association of 68Ga-FAPI uptake intensity, histopathologic grade, and F
Source: jnm.snmjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Complete Remission with Partial Hematological Recovery as a Palliative Endpoint for Treatment of Acute Myeloid Leukemia - 18 hour(s) ago
Key Points. CRh correlated with transfusion independence and delayed time to severe bleeding or infection with nonmyelosuppressive targeted therapies.CRh m
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
Leukemia – Genomic landscape of CCUS compared to MDS and its implications on risk prediction
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Nonprofits Are Making Billions off the Border Crisis - 18 hour(s) ago
Federal funding has turned the business of resettling migrant children into a goldmine for a handful of NGOs—and their top executives.
Source: www.thefp.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 37
PURPOSE Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment. PATIENTS AND METHODS Patients enrolled in the multicenter, randomized SYNCHRONOUS and CCRe-IV trials were included in the analysis. Patients with colon cancer with synchronous unresectable metastases were randomly assigned at 100 sites in Austria, Germany, and Spain to undergo PTR or up-front chemotherapy (No PTR group). The chemotherapy regimen was left at discretion of the local team. Patients with tumor-related symptoms, inability to tolerate surgery and/or systemic chemotherapy, and history of another cancer were excluded. The primary end point was overall survival (OS
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4JAK2 wild-type erythrocytosis associated with sodium-glucose cotransporter 2 inhibitor therapy - 4 day(s) ago
TO THE EDITOR:
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9Revolving doors: board memberships, hedge funds, and the FDA chiefs responsible for regulating industry - 5 day(s) ago
The US Food and Drug Administration says that it takes conflicts of interest seriously. But financial entanglements with the drug industry are common among its leaders. Peter Doshi reports At his public confirmation hearing in late 2021, Robert Califf, President Biden’s nominee to lead the US Food and Drug Administration (FDA), faced pointed questions about his financial relationships with industry. Bernie Sanders, the senator from Vermont, asked, “At a time when the American people are outraged by the high cost of prescription drugs, deeply disturbed about what happened with Purdue and Oxycontin, what kind of comfort can you give to the American people when you have been so closely tied to the pharmaceutical industry yourself?” He added, “How can the American people feel comfortable you’re going to stand up to this powerful special interest?” Califf responded: “Senator Sanders, I have a history of doing that. But I’d also point out that this administration has the most stringent ethic
Source: www.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Neoadjuvant immunotherapy in patients with melanoma... let's get ready for ASCO-2024 plenary ! - 5 day(s) ago
A re-analysis of the SWOG S1801 trial (neoadjuvant pembrolizumab versus adjuvant only), and more…
Source: www.drugdevletter.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 37
In a pair of Special Reports, Gökbuget and colleagues present updated European Leukemia Net (ELN) consensus reports on (1) the diagnosis, prognostic factor
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
RT @CalaisJeremie: FAP PET Improves Detection of Intermediate and Low-Grade #Sarcoma over FDG PET https://t.co/pkYPhN5a9B @JournalofNucMed…