Use of IL-6-elafin genetically modified regulatory macrophages as an immunotherapeutic against acute bacterial infection in the lung

Background: Pseudomonas aeruginosa (P.a) infections are a major public health issue in ventilator-associated pneumoniae, cystic fibrosis and chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium is multidrug resistant and there is an urgent need to develop new therapeutic approaches. Objective: Evaluate the effect of direct pulmonary transplantation of gene-modified (elafin…