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Mashup Score: 0Glioma Approval Sets New Course in Pediatric Drug Development - 13 hour(s) ago
The repositioning of shelved assets for pediatric applications presents a promising avenue for advancing therapies for childhood tumors. Tovorafenib, originally intended for adult melanoma, received approval in April as a treatment for pediatric low-grade glioma. This success has spurred hopes within the industry of replicating this achievement with other previously discontinued drug candidates.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 13TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity - 14 hour(s) ago
Preventing the feedback induction of TREX1 downstream of tumor cell STING results in robust interferon signaling and can render cancer cells vulnerable to NK and other immune cell–mediated killing, as well as immune checkpoint blockade.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2To Conquer KRAS, Drugmakers Take Aim at More Mutations - 15 hour(s) ago
Drugmakers are expanding their attack on KRAS mutations, with clinical trials now underway for therapies targeting the common G12D variant, as well as broader pan-RAS inhibitors. As reported at the American Association for Cancer Research Annual Meeting 2024, the multi-selective drug strategy is showing early promise, offering hope for more effective treatments across a wide range of RAS-driven cancers.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2
Abstract. Many cancer patients are at risk of developing cognitive symptoms that often become evident during or after cancer-directed therapy and may involve difficulties with attention, concentration, multitasking, executive function, and memory. Despite recent advances in identifying potential molecular and cellular mechanisms underlying cancer and chemotherapy-related cognitive impairment, there is generally a lack of effective treatment strategies, and the development of novel therapeutic interventions represents a major unmet medical need in clinical practice. A recent study by Kim and colleagues suggests that multi-sensory 40-Hz gamma entrainment using sensory stimuli (GENUS) with combined visual and auditory stimuli is associated with powerful neuroprotective effects in mouse models of cisplatin or methotrexate-induced ‘chemobrain’. While the study has some limitations and successful interventions in animal models have often failed to translate into clinical practice, this non-i
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 9Glioma Approval Sets New Course in Pediatric Drug Development - 15 hour(s) ago
The repositioning of shelved assets for pediatric applications presents a promising avenue for advancing therapies for childhood tumors. Tovorafenib, originally intended for adult melanoma, received approval in April as a treatment for pediatric low-grade glioma. This success has spurred hopes within the industry of replicating this achievement with other previously discontinued drug candidates.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 20
Adaptation of transfer learning to relate human single-cell RNA sequencing data to organoid-CAF cocultures facilitates discovery of human pancreatic cancer intercellular interactions and uncovers cross-talk between CAFs and tumor cells through VEGFA and ITGB1.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet-
New in Convergence Science from the May 1 issue— Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with EMT & Inflammation in Cancer Cells in PDAC, by Samantha Guinn, @DrRABurkhart, @FertigLab, @JZimmermanMDPhD et al. https://t.co/3RATluwLuh @ConvergenceInst https://t.co/TLHPNiaHGX
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Mashup Score: 3Why Kidney Cancer Rates Differ Globally - 17 hour(s) ago
An international genomics study has revealed distinct mutational signatures in kidney cancer that vary across different regions, illuminating the reasons behind global disparities in incidence rates. Highlighting the effect of both recognized and unidentified mutation-inducing agents, the research underscores the need for targeted public health interventions and further studies into the environmental factors linked to renal cell carcinoma.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer - 17 hour(s) ago
Loss of induction of immunogenic cell death in response to T-DM1 leads to resistance that can be overcome by targeting TACC3, providing an attractive strategy to improve the efficacy of T-DM1.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 3
Major Finding: Atypical memory (AtM) B cells reside within the tumor microenvironment and suppress antitumor immunity. Concept: A single-cell, B-cell atlas reveals a noncanonical pathway of B-cell maturation that impacts prognosis. Impact: This study highlights mechanisms that inform the development of B-cell–targeted immunotherapies.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1
Cancer Research | 84 | 10 | May 2024
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
Glioma Approval Sets New Course in Pediatric Drug Development | Cancer Discovery News | American Association for Cancer Research https://t.co/2xGvcY6gIH