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Mashup Score: 0Volume 18 Issue 2 | Cancer Prevention Research | American Association for Cancer Research - 16 hour(s) ago
Cancer Prevention Research | 18 | 2 | February 2025
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 815 Novel Cancer Drugs OK’d by FDA in 2024 - 18 hour(s) ago
The FDA’s Center for Drug Evaluation and Research issued its annual report on the approval of drugs, which announced that the agency OK’d 50 novel drugs in 2024, 15 of which were related to cancer care and treatment.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1SpatialDeX Is a Reference-Free Method for Cell-Type Deconvolution of Spatial Transcriptomics Data in Solid Tumors - 18 hour(s) ago
The development of a reference-free method for deconvolving the identity of cells in spatial transcriptomics datasets enables exploration of tumor architecture to gain deeper insights into the dynamics of the tumor microenvironment.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0Volume 85 Issue 3_Supplement | Cancer Research | American Association for Cancer Research - 19 hour(s) ago
Cancer Research | 85 | 3_Supplement | February 2025
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 16
Zongertinib, a covalent HER2 inhibitor, is active in HER2-driven preclinical models and patients and effectively targets HER2 oncogenic signaling while sparing wild-type EGFR, resulting in potent inhibition and improved tolerability.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0NSF Payment System Back Online - 21 hour(s) ago
The U.S. National Science Foundation (NSF) announced that payments have been restored to the researchers who receive funding from the independent federal agency. Grant-recipients’ salaries were suspended last week amid the Trump administration’s federal funding freeze on grants and federal loans. Subsequently, a federal court issued an order preventing federal grant-issuing agencies, including the NSF, from withholding awards.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 26Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes - 22 hour(s) ago
Multiplex imaging analysis of matched primary and metastatic breast tumors provides a phenotypic and spatial map of tumor microenvironments, revealing similar compositions of cancer cells and divergent immunologic features between matched samples.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 4
AbstractPurpose:. Datopotamab deruxtecan (Dato-DXd) is a humanized anti–trophoblast cell-surface antigen-2 (TROP2) IgG1 mAb linked to a potent topoisomerase I inhibitor payload (DXd). Dato-DXd has already shown antitumor activity in breast cancer; however, the determinants of response, including the importance of TROP2 expression, remain unclear. We tested the activity of Dato-DXd in a panel of breast cancer patient-derived xenografts (BCX) varying in TROP2 expression.Experimental Design:. The antitumor activity of Dato-DXd and isotype-control-DXd (IgG-DXd) was assessed against 11 BCXs varying in TROP2 expression, 10 representing tumors postneoadjuvant chemotherapy. Pharmacodynamic effects were assessed at 24 and 72 hours. The effects of TROP2 expression on Dato-DXd activity was assessed in vitro and in vivo using viral overexpression in BCX-derived cell lines.Results:. Models differed in their sensitivity to both Dato-DXd and IgG-DXd. Dato-DXd (10 mg/kg) led to objective response in 4
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0
Cancer Research | 85 | 3 | February 2025
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1RFK Jr. Refuses to Say HPV Vaccine Is Safe - 2 day(s) ago
At today’s Senate Health, Education, Labor, and Pensions Committee hearing, nominee for Secretary of the Department of Health and Human Services Robert F. Kennedy (RFK) Jr. refused to renounce his claims that the human papillomavirus (HPV) vaccine is “dangerous and defective.” When given the opportunity to do so, Kennedy instead pointed to an ongoing lawsuit involving Merck and claims the company didn’t adequately disclose the side effects of Gardasil, its HPV vaccine; Kennedy litigated the case at earlier stages and stands to profit if Merck loses. According to the U.S. Centers for Disease Control and Prevention, HPV infection causes nearly all cases of cervical cancer, and more than 90% of HPV-caused cancers––which also include some anal, penile, vulvar, vaginal, and head and neck cancers—can be prevented through vaccination.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
The February issue is online. https://t.co/ABtnEHC8Lo https://t.co/gAW1pbgfmK