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Mashup Score: 21Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease - 3 day(s) ago
The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer’s disease (AD) field. These tau PET tracers bind tau neurofibrillary ta…
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Mashup Score: 38Gray matter gamma‐hydroxy‐butyric acid and glutamate reflect beta‐amyloid burden at old age - 7 day(s) ago
Gamma-hydroxy-butyric acid (GABA) and glutamate are neurotransmitters with essential importance for cognitive processing. Here, we investigate relationships between GABA, glutamate, and brain ß-amyl…
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Happy to share our new paper! #GABA and #glutamate could be higher in very early #Alzheimer disease, before symptoms emerge, similar to other measures of #brain activity🧠⚡️ Is this activity promoting or preventing future damage and cognitive decline? ➡️https://t.co/CLEs7Q0ZUh https://t.co/vhldIzG87Q
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Mashup Score: 0Cardiometabolic disease, cognitive decline, and brain structure in middle and older age - 15 day(s) ago
INTRODUCTION The presence of multiple cardiometabolic diseases (CMDs) has been linked to increased dementia risk, but the combined influence of CMDs on cognition and brain structure across the life …
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Mashup Score: 50
INTRODUCTION Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer’s disease (LOAD), but few candidate polymorphisms have been functionally assess…
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Mashup Score: 125Cognitively healthy centenarians are genetically protected against Alzheimer's disease - 1 month(s) ago
BACKGROUND Alzheimer’s disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associate…
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Mashup Score: 10Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial - 1 month(s) ago
INTRODUCTION In trials of amyloid-lowering drugs for Alzheimer’s disease (AD), differential eligibility may contribute to under-inclusion of racial and ethnic underrepresented groups. We examined pl…
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Mashup Score: 27Biomarkers of chronic inflammation and cognitive decline: A prospective observational study - 1 month(s) ago
We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activato…
Categories: General Medicine News, CardiologistsTweet
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Mashup Score: 5Developing and describing a typology of lucid episodes among people with Alzheimer's disease and related dementias - 1 month(s) ago
INTRODUCTION This study examined lucid episodes among people living with late-stage Alzheimer’s disease and related dementias (PLWD) and then developed a typology of these episodes to help character…
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Mashup Score: 15
INTRODUCTION Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans. METHODS The present study used 17 years of data from a sample of …
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Mashup Score: 9
INTRODUCTION Screening for Alzheimer’s disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential for clinical management. We trained automatic spe…
Categories: General Medicine News, NeurologyTweet
Future directions of tau PET for clinical use In 2022, @OskarHansson9 and I identified the following knowledge gaps for optimal use of Tau PET in the clinic. Many of these still remain unaddressed. Link > https://t.co/9ZLO7mTt2e https://t.co/2hAfCIOy8G