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Mashup Score: 28Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer - 16 day(s) ago
Androgen receptor signaling is crucial for the development of treatment resistance in prostate cancer. Among steroidogenic enzymes, 3β-hydroxysteroid dehydrogenases (3βHSDs) play critical roles in extragonadal androgen synthesis, especially 3βHSD1. Increased expression of 3βHSDs is observed in castration-resistant prostate cancer tumors compared with primary prostate tumors, indicating their involvement in castration resistance. Recent studies link 3βHSD1 to resistance to androgen receptor signaling inhibitors. The regulation of 3βHSD1 expression involves various factors, including transcription factors, microenvironmental influences, and post-transcriptional modifications. Additionally, the clinical significance of HSD3B1 genotypes, particularly the rs1047303 variant has been extensively studied. The impact of HSD3B1 genotypes on treatment outcomes varies according to the therapy administered, suggesting the potential of HSD3B1 genotyping for personalized medicine. Targeting 3βHSDs ma
Source: erc.bioscientifica.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 33
In advanced pancreatic neuroendocrine neoplasms (PanNEN), there is little data detailing the frequency of genetic alterations identified in cell free DNA (cfDNA), plasma-tissue concordance of detected alterations, and clinical utility of cfDNA. Patients with metastatic PanNENs underwent cfDNA collection in routine practice. Next-generation sequencing (NGS) of cfDNA and matched tissue when available was performed. Clinical actionability of variants was annotated by OncoKB. Thirty-two cfDNA samples were analyzed from 25 patients, the majority who had well differentiated intermediate grade disease (13/25; 52%). Genomic alterations were detected in 68% of patients and in 66% of all cfDNA samples. The most frequently altered genes were DAXX (28%), TSC2 (24%), MEN1 (24%), ARID1B (20%), ARID1A (12%) and ATRX (12%). 23/25 (92%) patients underwent tumor tissue NGS. Tissue-plasma concordance for select genes was DAXX (95.7%), ARID1A (91.1%), ATRX (87%), TSC2 (82.6%), MEN1 (69.6%). Potentially ac
Source: erc.bioscientifica.comCategories: General Medicine News, Hem/OncsTweet-
cfDNA for panc NETs...? 25 mostly well diff pNETs. Genomic alterations in 66% of samples with high concordance with tissue testing for many (e.g.DAXX, ATRX, ARID1A) alterations and potentially actionable alterations detected in 32%. @DianeReidyLagun https://t.co/4adhOKrMvV
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Mashup Score: 6MEN1-related PanNETs: identifying unmet clinical needs and future directives in: Endocrine-Related Cancer - Ahead of print - 4 year(s) ago
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Source: erc.bioscientifica.comCategories: Hem/Oncs, Latest HeadlinesTweet-
It's been a remarkable decade as a patient-advocate. I went from finding tumors on my pancreas 10 years ago to being invited to contribute my perspective to a position paper on how to manage MEN1 from experts @MDAndersonNews @NIH @UMCU_Intl & elsewhere! https://t.co/Sga8FeXWGM
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Mashup Score: 2
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Source: erc.bioscientifica.comCategories: UrologyTweet-
Are #androgens hazardous with #COVID-19? Does this explain worse outcomes in men? Several mechanisms possible including regulation of 1) TMPRSS2 expression 2) immune stim 3) adrenal steroid metabolism. Just my thoughts with @charlesryanmd https://t.co/f0f2mRdXCS
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Interesting review on 3βHSD1 in prostate cancer just out from the group in Kyushu @Endocancer @Soc_Endo. Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer https://t.co/BkEsvUXLYu