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Mashup Score: 0
An abstract is unavailable.
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Mashup Score: 0Durvalumab + Ceralasertib Treatment in... : Oncology Times - 11 hour(s) ago
An abstract is unavailable.
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Mashup Score: 0
An abstract is unavailable.
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Mashup Score: 5Chronic overlapping pain conditions increase the risk of... : PAIN - 15 hour(s) ago
s could offer a valuable orientation for long COVID-related research and clinical care. This retrospective cohort study aimed to determine whether having a COPC predicts the onset of long COVID features using US electronic health records and 1:1 propensity score matching without replacement. The study cohorts included (1) people with acute COVID (n = 1,038,402), (2) people with acute influenza (n = 262,092), and (3) a noninfected cohort comprising people with a routine healthcare encounter (n = 1,081,593). Having a COPC increased the risk of long COVID features in all 3 study cohorts. Among those with COVID, having a pre-existing COPC increased the risk by 1.47 (95% CI = 1.46, 1.47). In the influenza cohort, COPCs increased the risk by 1.39 (95% CI = 1.38, 1.40). In the noninfected cohort, COPCs increased the risk by 1.57 (95% CI = 1.56, 1.59). These findings reinforce the likelihood that nociplastic mechanisms play a prominent role in long COVID. Recognizing that this ubiquitous nonsp
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 39Kidney Endothelial Cell Biology in Health and Disease : Journal of the American Society of Nephrology - 15 hour(s) ago
An abstract is unavailable.
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"...the insights gained from single-cell sequencing technologies have the potential to revolutionize our understanding of the diverse populations of kidney endothelial cells..." This Editorial discusses insights into lymphatic biology for kidney diseases https://t.co/gBAku9KI7R https://t.co/CP7I1aE2Ib
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Mashup Score: 94Sotagliflozin and Kidney Outcomes, Kidney Function, and... : Clinical Journal of the American Society of Nephrology - 15 hour(s) ago
f eGFR laboratory data and case report forms had not been completed. This resulted in a small number of kidney composite events and a nominal effect of sotagliflozin versus placebo on this outcome. This exploratory analysis uses laboratory eGFR data, regardless of case report form completion, to assess the effects of sotagliflozin on the predefined kidney composite end point in the SCORED trial and additional cardiorenal composite end points. Methods SCORED was a multicenter, randomized trial evaluating cardiorenal outcomes with sotagliflozin versus placebo in 10,584 patients with type 2 diabetes and CKD. This exploratory analysis used laboratory data to derive the eGFR components and case report form data for the non-laboratory–defined components that together made up the kidney and cardiorenal composites. AKI was also assessed in this dataset. Results Using laboratory data, 223 events were identified, and sotagliflozin reduced the risk of the composite of first event of sustained ≥50
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Mashup Score: 4Collection Details : Oncology Times - 17 hour(s) ago
Oncology Times reports essential clinical news for oncologists, hematologists and other cancer care
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Mashup Score: 12Single-Cell RNA Sequencing Identifies Response of Renal... : Journal of the American Society of Nephrology - 18 hour(s) ago
se renal lymphatic endothelial cells in quiescent and cisplatin-injured kidneys. Lymphatic endothelial cell gene expression changes were confirmed in ischemia–reperfusion injury and in cultured lymphatic endothelial cells, validating renal lymphatic endothelial cells single-cell RNA sequencing data. This study is the first to describe renal lymphatic endothelial cell heterogeneity and uncovers molecular pathways demonstrating lymphatic endothelial cells regulate the local immune response to AKI. These findings provide insights into previously unidentified molecular pathways for lymphatic endothelial cells and roles that may serve as potential therapeutic targets in limiting the progression of AKI. Background The inflammatory response to AKI likely dictates future kidney health. Lymphatic vessels are responsible for maintaining tissue homeostasis through transport and immunomodulatory roles. Owing to the relative sparsity of lymphatic endothelial cells in the kidney, past sequencing eff
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How lymphatics respond to AKI may affect AKI outcomes. This study found that lymphatic endothelial cell gene expression is altered between injury models, suggesting lymphatic endothelial cells respond to AKI may be key in regulating disease progression https://t.co/Ti2LSQUVpp https://t.co/taUltNS5kQ
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Mashup Score: 6Two Weeks Versus One Week of Maximal Patient-Intensivist... : Critical Care Medicine - 19 hour(s) ago
site B was in the Northeast. Patients: Patients 18 years old or older admitted to a study ICU between March 1, 2017, and February 28, 2020. Interventions: None. Measurements and Main Results: We applied target trial emulation to compare admission during an intensivist’s first week (as a proxy for 2 wk of maximal continuity) vs. admission during their second week (as a proxy for 1 wk of maximal continuity). Outcomes included hospital mortality, ICU length of stay, and, for mechanically ventilated patients, duration of ventilation. Exploratory outcomes included imaging, echocardiogram, and consultation orders. We used inverse probability weighting to adjust for baseline differences and random-effects meta-analysis to calculate overall effect estimates. Among 2571 patients, 1254 were admitted during an intensivist’s first week and 1317 were admitted during a second week. At sites A and B, hospital mortality rates were 25.8% and 24.2%, median ICU length of stay were 4 and 2 days, and media
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Mashup Score: 7Match Day 2024 Was a ‘Good News’ Day for Neurology : Neurology Today - 19 hour(s) ago
An abstract is unavailable.
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More than 1,100 neurology and nearly 200 child neurology residencies were included in #MatchDay2024—and program directors are thrilled neurology is getting the attention it deserves: https://t.co/pGBZi2jrr7 #NeuroTwitter @DrJeffRatliff @EricaSchuyler @CroninNeuro @REMatthewsMD https://t.co/LbAep4uVsB
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Via @NEJM: Lixisenatide seemed to slow motor disability in patients with early-stage #Parkinsons, but experts caution that the trial was small and of short duration: https://t.co/6hmUmIiW5W #NeuroTwitter @Univ_Toulouse @univbordeaux @MichaelOkun @UMneurosciences @YaleMed https://t.co/2sGrOd3xF0