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Mashup Score: 4The critical need for a robust research agenda on ultra-processed food consumption and cancer risk - 2 day(s) ago
Ultra-processed food consumption has increased worldwide, but associations with cancer risk remain unclear and potential underlying mechanisms are speculative. A robust, multidisciplinary, research agenda is needed to address current research limitations and gaps.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 2
Citation: Adams J (2024) The NOVA system can be used to address harmful foods and harmful food systems. PLoS Med 21(11): e1004492. https://doi.org/10.1371/journal.pmed.1004492 Copyright: © 2024 Jean Adams. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: JA is supported by the Medical Research Council [grant
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Mashup Score: 14Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study - 3 day(s) ago
Carey E. Gleason and colleagues investigate the long-term effects of hormone therapy started early in menopause on cognition, mood and neuroimaging by leveraging data from the follow up of the Kronos Early Estrogen Prevention Study (KEEPS) cohort of participants.
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Mashup Score: 2Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region - 3 day(s) ago
Integrating data from different experimental approaches into one model is challenging. This study presents a community-based, full-scale in silico model of the rat hippocampal CA1 region that integrates diverse experimental data from synapse to network.
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4
Behavioural contagion—the onset of a species-typical behaviour soon after witnessing it in a conspecific—forms the foundation of behavioural synchrony and cohesive group living in social animals. Although past research has mostly focused on negative emotions or neutral contexts, the sharing of positive emotions in particular may be key for social affiliation. We investigated the contagion of two socially affiliative interactive behaviours, grooming and play, in chimpanzees. We collected naturalistic observations of N = 41 sanctuary-living chimpanzees at Chimfunshi Wildlife Orphanage, conducting focal follows of individuals following observations of a grooming or play bout, compared with matched controls. We then tested whether the presence and latency of behavioural contagion was influenced by age, sex, rank, and social closeness. Our results offer evidence for the presence of grooming and play contagion in sanctuary-living chimpanzees. Grooming contagion appeared to be influenced by s
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 8
Information storage in neuronal circuits is hypothesized to involve nanoscopic structural changes at synapses, but direct evidence for this is lacking. This study uses nanophysiology and functional electron microscopy to reveal structural changes of hippocampal active zones during chemical potentiation.
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic liver disease - 4 day(s) ago
Background The relationship between community-based healthcare barriers and risk of recurrent hospital-based care among persons with chronic liver disease (CLD) is understudied. We aimed to uncover distinct groups among adults in the United States with CLD based on healthcare barriers and risk-stratify recurrent acute care use by group. Methods Using National Health Interview Survey (2011 to 2017) data, we performed latent class analysis (LCA) to uncover groups experiencing distinct sets of healthcare barriers. We assessed sociodemographic and health characteristics and probabilities of recurrent acute care use by group. Results The sample included 5,062 (estimated 4.7 million) adults with CLD (median [range] age 55 [18–85]). LCA modeling differentiated 4 groups: minimal barriers (group 1) (n = 3,953; 78.1%), unaffordability (group 2) (n = 540; 10.7%), care delays (group 3) (n = 328; 6.5%), and inability to establish care (group 4) (n = 240; 4.8%). Group 2 had the most uninsured person
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Mashup Score: 11Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes - 5 day(s) ago
Background While Type 2 Diabetes Mellitus (T2DM) prevalence is increasing among younger individuals, few studies have examined how age at T2DM diagnosis relates to dementia risk in diabetic populations. We aimed to investigate the association between age at T2DM diagnosis and subsequent dementia risk, and to determine whether obesity moderates this relationship. Methods We conducted a prospective cohort study using data from the Health and Retirement Study (2002–2016) matched with its 2003 Diabetes Mail-Out Survey. The study included 1,213 dementia-free adults aged ≥50 with diagnosed T2DM. Primary exposures were age at T2DM diagnosis (categorized as <50, 50–59, 60–69, and ≥70 years) and obesity status (BMI ≥30 kg/m2). The outcome was incident dementia, assessed using the Telephone Interview for Cognitive Status. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for sociodemographic factors, health behaviors, health s
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Mashup Score: 24Trajectories of human brain functional connectome maturation across the birth transition - 5 day(s) ago
How do the functional networks in the brain change at the beginning of human life? This longitudinal perinatal fMRI study of 140 babies reveals regionally specific changes in neural connectivity at the birth transition, with some areas showing minimal variation while others show increases in connectivity at birth.
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Mashup Score: 5Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course - 9 day(s) ago
How do repeated influenza infections generate such a complex immunological landscape? This study of influenza A/H3N2 in humans estimated lifetime infection histories for 1,130 individuals, reconstructing influenza incidence and antibody patterns across age, location, and time.
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet
Erikka Loftfield and team discuss that while consumption of ultra-processed foods has increased worldwide, associations with cancer risk remain unclear and underlying mechanisms speculative. Time for a robust, multidisciplinary research agenda? đź“Ž: https://t.co/Nc08V48kzx https://t.co/vF3talP1uv