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Mashup Score: 28Uric Acid - 2 year(s) ago
Uric acid (UA) is a strong endogenous antioxidant that neutralizes the toxicity of peroxynitrite and other reactive species on the neurovascular unit generated during and after acute brain ischemia. The realization that a rapid reduction of UA levels during an acute ischemic stroke was associated with a worse stroke outcome paved the way to investigate the value of exogenous UA supplementation to counteract the progression of redox-mediated ischemic brain damage. The long translational journey for UA supplementation recently reached a critical milestone when the results of the multicenter NIH stroke preclinical assessment network (SPAN) were reported. In a novel preclinical paradigm, 6 treatment candidates including UA supplementation were selected and tested in 6 independent laboratories following predefined criteria and strict methodological rigor. UA supplementation was the only intervention in SPAN that exceeded the prespecified efficacy boundary with male and female animals, young
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis - 2 year(s) ago
Objective: Previous studies have reported a possible prodrome in multiple sclerosis (MS) defined by non-specific symptoms including mood disorder or genito-urinary symptoms and increased health care use detected several years before diagnosis. This study aimed to evaluate agnostically the associations between diseases and symptoms diagnosed in primary care and the risk of multiple sclerosis (MS) relative to controls and two other autoimmune inflammatory diseases with similar population characteristics, namely lupus and Crohn’s disease. Methods: A case-control study was conducted using electronic health records from the Health Improvement Network database in the UK and France. We agnostically assessed the associations between 113 diseases and symptoms in the five years before and after diagnosis in patients with subsequent diagnosis of MS. Individuals with a diagnosis of MS were compared to individuals without MS, and individuals with two other auto-immune diseases, Crohn’s disease and
Source: n.neurology.orgCategories: General Medicine News, General HCPsTweet-
Multiple #sclerosis: New study highlights five warning signs of the disease @InstitutCerveau https://t.co/u9fzAyzMv1 https://t.co/6EDECxoBJT
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Mashup Score: 168Teaching Video NeuroImage: The Digiti Quinti Sign as the Sole Objective Sign of Mild Hemiparesis - 2 year(s) ago
An 86-year-old man with hypertension, hyperlipidemia, type II diabetes, and atrial fibrillation (anticoagulated with low-dose rivaroxaban) presented with a 24-hour weakness of his left limbs, with difficulty in performing daily tasks.
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
Teaching Video NeuroImage: The Digiti Quinti Sign as the Sole Objective Sign of Mild Hemiparesis https://t.co/IulfHS8lbH #NeurologyRF #NeuroTwitter https://t.co/AEUjLY5Itw
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Mashup Score: 25Large Language Models in Neurology Research and Future Practice - 2 year(s) ago
Recent advancements in generative artificial intelligence, particularly using large language models (LLMs), are gaining increased public attention. We provide a perspective on the potential of LLMs to analyze enormous amounts of data from medical records and gain insights on specific topics in neurology. In addition, we explore use cases for LLMs, such as early diagnosis, supporting patient and caregivers, and acting as an assistant for clinicians. We point to the potential ethical and technical challenges raised by LLMs, such as concerns about privacy and data security, potential biases in the data for model training, and the need for careful validation of results. Researchers must consider these challenges and take steps to address them to ensure that their work is conducted in a safe and responsible manner. Despite these challenges, LLMs offer promising opportunities for improving care and treatment of various neurologic disorders . AI= : artificial intelligence; IMDRF= : Internatio
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
Free to read: Large Language Models in Neurology Research and Future Practice https://t.co/JBYzkvv1WD #NeuroTwitter #AI https://t.co/jousThsoEE
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Mashup Score: 23Neurology: 101 (23) - 2 year(s) ago
Regina Royan, Tracy E. Madsen Sonia L. Bonifacio, Linda S. de Vries Anita Lindmark, Marie Eriksson, David Darehed Reem Waziry, Yian Gu, Amelia K. Boehme, Olajide A. Williams Woo-Jin Lee, Shin-Hye Baek, Hee-Jin Im, Seung-Ku Lee, Jee-Eun Yoon, Robert J. Thomas, Yun-Kwok Wing, Chol Shin, Chang-Ho Yun Alex C. Bender, Afareen Jaleel, Kyle R. Pellerin, Sebastian Moguilner, Rani A. Sarkis, Sydney S. Cash, Alice D. Lam Kirandeep Kaur, Gautam Sharma, Rekha Dwivedi, Ashima Nehra, Niranjan Parajuli, Ashish D.
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
Check out the latest issue of Neurology journal: https://t.co/En2CZsWwmJ #NeuroTwitter https://t.co/4F4K29BMoH
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Mashup Score: 1Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis - 2 year(s) ago
Objectives To examine the agreement between published reference resources for neurofilament light chain (NfL) applied to a large population of people with multiple sclerosis (MS). Methods Six published reference resources were used to classify NfL in participants in the Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network as elevated or normal and to derive age-specific NfL Z -scores. NfL values were classified as elevated if they exceeded the >95th percentile (i.e., Z -score >1.645) of the age-specific reference range. Furthermore, age-specific NfL Z -scores could be derived for 4 of 6 reference resources. Results NfL measurements were assessed from 12,855 visits of 6,687 people with MS (median 2 samples per individual [range 1–7]). The mean ± SD age was 47.1 ± 11.7 years, 72.1% of participants were female, disease duration was 15.0 ± 10.6 years, body mass index was 28.6 ± 6.9 kg/m2, and serum NfL was 12.87 ± 12.86 pg/mL. Depending on the selection
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis https://t.co/zO9eMFqyjx
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Mashup Score: 1Association of Blood-Based DNA Methylation Markers With Late-Onset Alzheimer Disease - 2 year(s) ago
Background and Objectives There is an urgent need to identify novel noninvasive biomarkers for Alzheimer disease (AD) diagnosis. Recent advances in blood-based measurements of phosphorylated tau (pTau) species are promising but still insufficient to address clinical needs. Epigenetics has been shown to be helpful to better understand AD pathogenesis. Epigenetic biomarkers have been successfully implemented in other medical disciplines, such as oncology. The objective of this study was to explore the diagnostic accuracy of a blood-based DNA methylation marker panel as a noninvasive tool to identify patients with late-onset Alzheimer compared with age-matched controls. Methods A case-control study was performed. Blood DNA methylation levels at 46 cytosine-guanine sites (21 genes selected after a comprehensive literature search) were measured by bisulfite pyrosequencing in patients with “probable AD dementia” following National Institute on Aging and the Alzheimer’s Association guidelines
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
Association of Blood-Based DNA Methylation Markers With Late-Onset Alzheimer Disease: A Potential Diagnostic Approach https://t.co/PnLkDxNwwV
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Mashup Score: 28Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults - 2 year(s) ago
Background and Objectives It has been suggested that higher triglyceride levels were associated with a lower risk of Alzheimer disease. This study aimed to examine the association of triglycerides with dementia and cognition change in community-dwelling older adults. Methods This prospective longitudinal study used data from the Aspirin in Reducing Events in the Elderly (ASPREE) randomized trial of adults aged 65 years or older without dementia or previous cardiovascular events at enrollment. The main outcome was incident dementia. Other outcomes included changes in composite cognition and domain-specific cognition (global cognition, memory, language and executive function, and psychomotor speed). The association between baseline triglycerides and dementia risk was estimated using Cox proportional hazard models adjusting for relevant risk factors. Linear mixed models were used to investigate cognitive change. The analysis was repeated in a subcohort of participants with available APOE
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
This study found that older adults with higher #triglyceride levels within the normal to high-normal range had a lower #dementia risk and slower cognitive decline over time compared with individuals with lower triglyceride levels. Learn more: https://t.co/IywSXvxIyb https://t.co/lUcdkENfse
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Mashup Score: 32Association of EEG Background and Neurodevelopmental Outcome in Neonates With Hypoxic-Ischemic Encephalopathy Receiving Hypothermia - 2 year(s) ago
Background and Objectives Predicting neurodevelopmental outcome for neonates with hypoxic-ischemic encephalopathy (HIE) is important for clinical decision-making, care planning, and parent communication. We examined the relationship between EEG background and neurodevelopmental outcome among children enrolled in a trial of erythropoietin or placebo for neonates with HIE treated with therapeutic hypothermia. Methods Participants had EEG recorded throughout hypothermia. EEG background was classified as normal, discontinuous, or severely abnormal (defined as burst suppression, low voltage suppressed, or status epilepticus) at 5 1-hour epochs: onset of recording, 24, 36, 48, and 72 hours after birth. The predominant background pattern during the entire continuous video EEG monitoring recording was calculated using the arithmetic mean of the 5 EEG background ratings (normal = 0; discontinuous = 1; severely abnormal = 2) as follows: “predominantly normal” (mean = 0), “normal/discontinuous” (
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
This study examined the relationship between #EEG background and neurodevelopmental outcome among children enrolled in a trial of erythropoietin or placebo for neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia. Read more: https://t.co/kPcux7iYtk https://t.co/LQDOsyzZTZ
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Mashup Score: 82Clinical Reasoning: A 24-Year-Old Pregnant Woman With Headache and Behavioral Change Progressing to Coma - 2 year(s) ago
The broad differential diagnosis associated with progressive subacute encephalopathy can be intimidating, especially in a young, pregnant woman. In this case, a 24-year-old woman at 21 weeks of gestation presented with persistent, drug-resistant fronto-parietal headache, with subsequent progressive development of psychomotor lentification and inappropriate behavior. Physical examination was normal, as were routine laboratory parameters and CT findings, and these symptoms were initially interpreted in the context of chronic depression. Later, the patient developed generalized dystonia and fever, with rapid clinical deterioration, depression of consciousness and, eventually, progression to coma. This case emphasizes the complexity and challenges involved in the diagnostic approach to a patient with progressive subacute encephalopathy framed by worsening CNS symptoms. It highlights the clinical considerations and complementary investigation of various etiologies, in a step-by-step approac
Source: n.neurology.orgCategories: General Medicine News, NeurologyTweet-
A 24-yo pregnant woman at 21 weeks gestation developed a subacute, persistent, drug-resistant frontoparietal headache, for which she presented several times to her local emergency department over the course of 20 days. Read more: https://t.co/vqtUzAEGHk #NeurologyRF https://t.co/2tGmsZ5It8
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This descriptive review summarizes the translational development of uric acid supplementation, highlighting aspects that likely contributed to its success. Read the article: https://t.co/GBVF2Vq94s #NeuroTwitter #stroke https://t.co/7QIvRicaht