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Mashup Score: 6Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data - Nature Reviews Cancer - 2 year(s) ago
This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and patient samples, and presents an evolutionary model of PDAC progression based primarily on genomics studies of human PDAC.
Source: Nature Reviews CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Glycogen condensates drive tumorigenesis by trapping Hippo kinases - Nature Reviews Cancer - 2 year(s) ago
Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Glycogen condensates drive tumorigenesis by trapping Hippo kinases - Nature Reviews Cancer - 2 year(s) ago
Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Frozen silicified vaccines - Nature Reviews Cancer - 2 year(s) ago
Guo et al. have developed a novel strategy, which involves coating tumour cells with silica, to enable personalized cancer vaccines to overcome the immunosuppressive effects of the tumour microenvironment.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Amplifying targeting - Nature Reviews Cancer - 2 year(s) ago
Kaushik Tiwari et al. have developed a strategy to directly target amplified genes in cancer using triplex-forming oligonucleotides, which selectively induce DNA damage and apoptosis in cancer cells with copy number gains.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 11Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data - Nature Reviews Cancer - 2 year(s) ago
This Review outlines our current understanding of the evolution and heterogeneity of pancreatic ductal adenocarcinoma (PDAC), which has advanced owing to the study of preclinical models and patient samples, and presents an evolutionary model of PDAC progression based primarily on genomics studies of human PDAC.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Taming TAMs in brain metastases - Nature Reviews Cancer - 2 year(s) ago
Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 7Connecting copper and cancer: from transition metal signalling to metalloplasia - Nature Reviews Cancer - 2 year(s) ago
This Perspective explores the connection between copper and cancer and how challenges in the field could be addressed, and is a synthesis of discussions from the Copper Cancer Consortium, a meeting of experts in the field that took place in March 2020.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NEW Perspective! @evajge, @bradylabupenn, @christhechang &co explore the connection between copper & cancer. It is a synthesis of discussions from the Copper Cancer Consortium, a meeting of experts @cshlbanbury. https://t.co/ndTbieG0b4 @natrescancer @UCB_Chemistry @berkeleyMCB https://t.co/5IxBHxQGKj
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Mashup Score: 14Taming TAMs in brain metastases - Nature Reviews Cancer - 2 year(s) ago
Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Bacterial sabotage - Nature Reviews Cancer - 2 year(s) ago
Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
ICYMI: In @NatureRevCancer #PancreaticCancer evolution and heterogeneity: integrating omics and clinical data https://t.co/Hpj2QyRGak https://t.co/Ys5lh2Dlik