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Mashup Score: 9Peptide-triggered IL-12 and IFN-γ mediated immune response in CD4+ T-cells against Leishmania donovani infection - 1 month(s) ago
Leishmania donovani are intracellular, human blood parasites that cause visceral leishmaniasis or kala-azar. Cell-penetrating peptides (CPPs) have been shown to modulate intracellular processes and cargo delivery, whereas host defense peptides (HDPs) promote proliferation of both naïve and antigen activated CD4+ T-
Source: pubs.rsc.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 4Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing - 2 month(s) ago
The clinical translation of many biomolecular therapeutics has been hindered by undesirable pharmacokinetic (PK) properties, inadequate membrane permeability, poor endosomal escape and cytosolic delivery, and/or susceptibility to degradation. Overcoming these challenges merits the development of nanoscale dr
Source: pubs.rsc.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 12Continuous-flow electrorotation (cROT): improved throughput characterization for dielectric properties of cancer cells - 5 month(s) ago
This paper presents the concept of a newly developed high-throughput measurement device for determining the dielectric properties of cancer cells. The proposed continuous-flow electrorotation (cROT) device can induce electrorotation (ROT) with vertical rotation using two sets of interdigitated electrodes on
Source: pubs.rsc.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 17Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study - 5 month(s) ago
Flavan-3-ols are bioactive compounds found in a variety of fruits and vegetables (F&V) that have been linked to positive health benefits. Increasing habitual flavan-3-ol intake is challenged by the generally low consumption of F&V. While smoothies are a commonly endorsed, consumer-accepted means to increase the dai
Source: pubs.rsc.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 8The digestion and absorption characteristics of human milk phospholipid analogs: a combination study between in vitro and in vivo - 5 month(s) ago
Phospholipids play a crucial role in the growth and neurodevelopment of infants. Currently, soybean phospholipids (SPLs) are the common phospholipid component in most infant formulas (IFs), which, however, shows an obvious difference with the phospholipid (PL) composition of human milk fat. Therefore, in the presen
Source: pubs.rsc.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 14Discovery of a selective TC-PTP degrader for cancer immunotherapy - 6 month(s) ago
T-cell protein tyrosine phosphatase (TC-PTP), encoded by PTPN2, has emerged as a promising target for cancer immunotherapy. TC-PTP deletion in B16 melanoma cells promotes tumor cell antigen presentation, while loss of TC-PTP in T-cells enhances T-cell receptor (TCR) signaling and stimulates cell proliferation and a
Source: pubs.rsc.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 48LoCKAmp: lab-on-PCB technology for <3 minute virus genetic detection - 6 month(s) ago
The recent COVID-19 outbreak highlighted the need for lab-on-chip diagnostic technology fit for real-life deployment in the field. Existing bottlenecks in multistep analytical microsystem integration and upscalable, standardized fabrication techniques delayed the large-scale deployment of lab-on-chip solutio
Source: pubs.rsc.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 0
Extracellular vesicles (EVs), including nanoscale exosomes and ectosomes, hold promise as biomarkers that provide information about the cell of origin through their cargo of nucleic acids and proteins, both on their surface and within. Here, we develop a detection method of EVs based on light-induced acceler
Source: pubs.rsc.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 9A New Tissue-Agnostic Microfluidic Device to model physiology and disease: The Lattice Platform - 7 month(s) ago
To accurately phenocopy human biology in vitro, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards three-dimensional (3D) and/or multicellular culture techniques. While these culture innovations are becoming more commonplace, there
Source: pubs.rsc.orgCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Low-carbohydrate diet and risk of cardiovascular disease, cardiovascular and all-cause mortality: a systematic review and meta-analysis of cohort studies - 7 month(s) ago
Background: Evidence for the long-term health effect of low-carbohydrate diets (LCDs) is inconsistent. Herein, we aimed to examine the associations of LCDs with cardiovascular disease (CVD) and all-cause and cause-specific mortality. Methods: We searched PubMed, EMBASE, and the Web of Science up to 26 July 2023 for
Source: pubs.rsc.orgCategories: Healthcare Professionals, Latest HeadlinesTweet
🔬 Scientists reported newly designed tripeptides that were able to trigger 🌡️ proinflammatory cytokine (IL-12 and IFN-γ) secretion by CD4+CD44+ T cells in response to Leishmania donovani #infection. @ChemCommun | 🔗 https://t.co/DEXItuhGca https://t.co/cuEtUdTlom