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Mashup Score: 195Paxlovid: A Regulatory Gamble - 27 day(s) ago
On December 22, 2021, the US Food and Drug Administration (FDA) issued emergency use authorization (EUA) for the combination of nirmatrelvir and ritonavir tablets co-packaged and sold by Pfizer (New York, NY) under the name Paxlovid for individuals over the age of 12 years. Data supporting EUA comes from EPIC-HR, a randomized, double-blind, placebo-controlled trial of adult patients with COVID-19 who had one or more risk factors for progression to severe disease (Table).1-3 Crucially, none of the participants had received a COVID-19 vaccine or had a prior documented infection with COVID-19.
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Mashup Score: 26
In June of 2021, Klein and colleagues1 reported the results of a prospective, case-controlled, observational study on the clinical validity of a multi-cancer early detection (MCED) test developed by GRAIL, Inc. Based on a blood draw providing cell-free DNA (deoxyribonucleic acid) and its interpretation through machine learning, this test has been developed with the aim of increasing the number of detected cancers through population screening. The authors reported a specificity for cancer signal detection of 99.5% and an overall sensitivity of 51.5%.
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Mashup Score: 6Management of Clostridioides difficile infection: Diagnosis, Treatment, and Future Perspectives - 1 month(s) ago
Clostridioides difficile infection is the most common healthcare-associated infection in the United States, with potential life-threatening complications and significant impact in the costs of care. Antibiotic stewardship as well as discontinuation of chronic acid suppressive therapy are key for its prevention and treatment. Effective infection management requires appropriate interpretation of diagnostic tests, as well as the use of vancomycin and fidaxomicin as first-line treatment. Novel treatments as Bezlotoxumab, fecal microbiota transplant and live biotherapeutic products are proven effective in recurrent C.
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Mashup Score: 8Measuring the Jugular Venous Pressure: Do Not Turn the Head! - 2 month(s) ago
On the acute medical ward, reliable bedside assessment of the patient’s central blood volume is just as important now as it ever was. As the prevalence of heart failure increases, more elderly patients are being admitted with acute dyspnea secondary to volume overload. The best way to estimate blood volume at bedside is to measure the jugular venous pressure.1-5 Just as important as the high jugular venous pressure in the dyspneic patient is the low jugular venous pressure in the hypotensive patient.
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Mashup Score: 0Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle - 2 month(s) ago
Vasculogenic erectile dysfunction has been aptly called the “canary in the coal mine” for cardiovascular disease because it almost always precedes other manifestations of atherosclerotic cardiovascular disease, including myocardial infarction and stroke. It is common, associated with the presence of modifiable cardiovascular risk factors, and impacted by diet and lifestyle choices. This concise review provides an update on the use of dietary and other lifestyle interventions to improve vasculogenic erectile dysfunction and atherosclerotic cardiovascular disease.
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Mashup Score: 3“Benign” monoclonal gammopathy: A potentially malignant condition? - 3 month(s) ago
We describe a patient in whom classic clinical multiple myeloma did not develop until eighteen years after discovery of an elevated erythrocyte sedimentation rate, hyperglobulinemia and increased plasma cells in the bone marrow. The patient exhibited a tall, sharp peak in the serum electrophoretic pattern, no appreciable change in the amount of serum γ-globulin (which was less than 3.0 gm. per 100 ml.), and a constant slight plasmacytosis in the bone marrow for nearly eighteen years, thus fulfilling the criteria for “benign monoclonal gammopathy.” This illustrates the possibility that this “chronic benign process” can erupt into a progressive and serious phase at a much later date, and extends our understanding of plasmaproliferative disease.
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Mashup Score: 1Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019 - 3 month(s) ago
There are concerns that transcatheter or surgical aortic valve replacement (TAVR/SAVR) procedures are preferentially available to White patients.
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Mashup Score: 27Optimal Prescribing of Statins to Reduce Cardiovascular Disease - 4 month(s) ago
Cardiovascular disease is the most common cause of death in the United States and worldwide. Most of this disease is preventable with improvement of lifestyle and medication to reduce circulating cholesterol. The most common medications prescribed to reduce cholesterol are statins, which inhibit the hepatic enzyme HMG-CoA reductase, the limiting enzyme in cholesterol synthesis. Unfortunately, statins are rarely prescribed correctly, resulting in excessive adverse events and very poor patient compliance.
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Mashup Score: 26Optimal Prescribing of Statins to Reduce Cardiovascular Disease - 4 month(s) ago
Cardiovascular disease is the most common cause of death in the United States and worldwide. Most of this disease is preventable with improvement of lifestyle and medication to reduce circulating cholesterol. The most common medications prescribed to reduce cholesterol are statins, which inhibit the hepatic enzyme HMG-CoA reductase, the limiting enzyme in cholesterol synthesis. Unfortunately, statins are rarely prescribed correctly, resulting in excessive adverse events and very poor patient compliance.
Source: www.amjmed.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Optimizing the Internal Medicine Residency Recruitment Process: A National Survey of Program Directors and Next Steps - 4 month(s) ago
One consequence of the COVID-19 pandemic on the undergraduate to graduate medical education (UME-GME) transition was the elimination of in-person interviews during the recruitment season. Although public safety concerns were the initial drivers, other benefits quickly became evident, including applicant and program resource savings, reduced disruption to concurrent educational activities, fewer environmental effects from travel, and fewer barriers to faculty interviewer engagement. Much has been written about the effect of this change in interview season format1-5.
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We called Paxlovid a regulatory gamble and it looks like it went bust This is am important question https://t.co/Y9Vmr9o5Sa https://t.co/mSpgMEC4wB