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Mashup Score: 2Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma - 7 hour(s) ago
Abstract. PURPOSE: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to treatment of less complex, susceptible disease or inaccuracy in clinical definition of cases entered. EXPERIMENTAL DESIGN: Here, we interrogated whole genome and whole exome sequencing for 54 patients across two HR-SMM interventional studies (NCT01572480, NCT02279394). RESULTS: We reveal that the genomic landscape of treated HR-SMM is generally simple as compared to Newly Diagnosed (ND)MM counterparts with less inactivation of tumor suppressor genes, RAS pathway mutations, MYC disruption, and APOBEC contribution. The absence of these events parallels that of indolent precursor conditions, possibly explaining overall excellent outcomes. However, some patients harboring genomic complexity fail to sustain response and experience resistant, progressive disease. Overall, clinical risk scores do not effectively discrim
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Program Guide – ASCO Meeting Program Guide - 3 day(s) ago
Kamya Sankar, Jacob Mercer, Ellen Jaeger, Jen Godden, Jonathan Berkman, Edward Williams, Michael Thompson, Shetal Patel, Karen Reckamp, Frank Weinberg Cedars-Sinai Medical Center, Tempus AI, Tempus Labs, Inc., VCU Massey Cancer Center, The University of North Carolina at Chapel Hill, D epartment of Hematology/Oncology, University of Illinois, Chicago College of Medicine This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Program Guide – ASCO Meeting Program Guide - 3 day(s) ago
Yuan Yuan, Irene Kang, Jin Sun Bitar, Andrew Davis, Christie Hilton, Minxuan Huang, Michael Thompson, Jacob Mercer, Stephen Shiao, Eric Vail Cedars-Sinai Medical Center, City of Hope, Washington University in St. Louis, Allegheny Health Network, Tempus AI This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Program Guide – ASCO Meeting Program Guide - 3 day(s) ago
Christine Ho Roswell Park Comprehensive Cancer Center, Buffalo, NY Christine Ho, Paul K. Wallace, Kristopher Attwood, Sarah Parker, Hemn Mohammadpour, Megan Herr, George Chen, Joseph Tario, Philip L. McCarthy, Jens Hillengass Roswell Park Comprehensive Cancer Center, Buffalo, NY, Roswell Park Comprehensive Cancer Center, Transplant and Cellular Therapy Program, Department of Medicine, Buffalo, NY Background: Multiple myeloma (MM) is an incurable plasma cell malignancy. Precursor conditions include
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Program Guide – ASCO Meeting Program Guide - 3 day(s) ago
Ghulam Rehman Mohyuddin University of Utah, Salt Lake City, UT Ghulam Rehman Mohyuddin, Jennifer M. Ahlstrom, Cynthia Chmielewski, Nathan W. Sweeney, Thomas H. Molina, Christian S. Cheung, Emily Watabe Ballard, Felicia Seng, Amandeep Godara, Brian McClune, Douglas W. Sborov University of Utah, Salt Lake City, UT, HealthTree Foundation, Lehi, UT, The Myeloma Crowd, Lawrenceville, NJ, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, Huntsman Cancer Center, University of Utah, Salt Lake
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Program Guide – ASCO Meeting Program Guide - 3 day(s) ago
Sridurga Mithraprabhu Alfred Hospital / Monash University, Melbourne, Australia Sridurga Mithraprabhu, John Reynolds, Rose Turner, Anna Kalff, Krystal Bergin, HANG QUACH, Tiffany Khong, Brian G. Durie, Andrew Spencer Alfred Hospital / Monash University, Melbourne, Australia, Alfred Health, Prahran, Australia, Alfred Hospital, Melbourne, Australia, University of Melbourne, St. Vincent’s Hospital Melbourne, Melbourne, VIC, Australia, Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA, Malignant
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Program Guide – ASCO Meeting Program Guide - 4 day(s) ago
Suresh Ramalingam Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute Suresh Ramalingam, Terufumi Kato, Xiaorong Dong, Myung-Ju Ahn, Le-Van Quang, Nopadol Soparattanapaisarn, Takako Inoue, Chih-Liang Wang, Meijuan Huang, James Chih-Hsin Yang, Manuel Cobo, Mustafa Özgüroğlu, Ignacio Casarini, Dang-Van Khiem, Virote Sriuranpong, Eduardo Cronemberger, Xiangning Huang, Toon van der Gronde, Dana Ghiorghiu, Shun Lu Department of Hematology and Medical
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Program Guide – ASCO Meeting Program Guide - 4 day(s) ago
Joseph Greer Massachusetts General Hospital, Harvard Medical School Joseph Greer, Chardria Trotter, Vicki Jackson, Simone Rinaldi, Mihir Kamdar, Areej El-Jawahri, Nora Horick, Kedie Pintro, Dustin Rabideau, Josephine Feliciano, Isaac Chua, Konstantinos Leventakos, Stacy Fischer, Toby Campbell, Michael Rabow, Finly Zachariah, Laura Hanson, Sara Martin, Maria Silveira, Jennifer Temel Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Johns Hopkins University, Dana-Farber
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0#PallOnc - Healthcare Social Media Analytics and Transcripts - 4 day(s) ago
In an effort to ensure that oncology professionals are providing the highest-quality care, ASCO strives to offer resources and forums to discuss the best
Source: www.symplur.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Program Guide – ASCO Meeting Program Guide - 4 day(s) ago
Christian Blank Netherlands Cancer Institute (NKI-AVL), Department of Medical Oncology Christian Blank, Minke Lucas, Richard Scolyer, Bart van de Wiel, Alexander Menzies, Marta Lopez-Yurda, Alexander van Akkooi, Winan van Houdt, Robyn Saw, Alex Torres Acosta, Serigne Lo, Geke Hospers, Matteo Carlino, Jan Willem de Groot, Ellen Kapiteijn, Karijn Suijkerbuijk, Piotr Rutkowski, Shahneen Sandhu, Astrid Van Der Veldt, Georgina Long Netherlands Cancer Institute (NKI-AVL), Department of Medical Oncology, The
Source: meetings.asco.orgCategories: General Medicine News, Hem/OncsTweet
Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma [Apr 23, 2024] Kazandjian @BenDiamondMD et al. @FrancescoMaura4 @DrOlaLandgren @CCR_AACR https://t.co/XVb2F13qew #mmsm #cagenome https://t.co/jkGIqqUt3O