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Mashup Score: 0Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 3 hour(s) ago
Various infections trigger a storm of proinflammatory cytokines in which IL-6 acts as a major contributor and leads to diffuse alveolar damage in patients. However, the metabolic regulatory mechani…
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Mashup Score: 3Constructing the Framework for Disease Modification in Pulmonary Arterial Hypertension - 5 hour(s) ago
“.” American Journal of Respiratory and Critical Care Medicine, 209(10), pp. 1189โ1195 Correspondence and requests for reprints should be addressed to Roham T. Zamanian, M.D., Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, 300 Pasteur Drive, East Pavilion, Room G324, MC 5236, Stanford, CA 94306. E-mail: [email protected]. Supported by NIH Division of Intramural Research grants R01 HL134776, R01 HL134776-02, and R01 HL159886-01. Author Contributions: All authors reviewed
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Mashup Score: 5A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma - 5 hour(s) ago
Rationale: Density thresholds in computed tomography (CT) lung scans quantify air trapping (AT) at the whole-lung level but are not informative for AT in specific bronchopulmonary segments. Objecti…
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Mashup Score: 1
Rationale: Surgical lung biopsies are often required for the definitive diagnosis of nonmalignant pediatric diffuse lung diseases; however, the literature on mortality after surgical lung biopsy in…
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Mashup Score: 0
In a 1892 publication, Sir William Osler described difficulty in exhaling as a prominent symptom of asthma, highlighting that expiration was โprolonged and also wheezyโ (1). His clinical descriptions marked an early recognition of air trapping (AT) in asthma. Over time, our understanding of AT as a pathophysiological component of asthma has evolved, driven in part by advances in the ways to measure it. In the early 1990s, Webb and colleagues were the first to describe the observation of AT on expiratory
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Mashup Score: 1Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 13 hour(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
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Mashup Score: 3Pumping Iron Burns Fat in Lung Injury - 22 hour(s) ago
Acute respiratory distress syndrome (ARDS) poses a significant clinical challenge, and the mainstay of treatment is primarily supportive (1). Corticosteroids have been tested in ARDS with variable results, and the full impact of their use as a generalized therapy in ARDS is debated (2). Broad immunosuppression in ARDS is not fully supported by our understanding of lung immunity. Indeed, inflammation is not ubiquitously harmful and is actually necessary for important biological functions such as host
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Mashup Score: 28Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation - 1 day(s) ago
Although lifesaving, mechanical ventilation is also associated with iatrogenic complications. Perhaps the best-known examples are ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, but other forms of ventilator-associated iatrogenesis may exist and must be understood to improve outcomes for mechanically ventilated patients. Here, we argue that ventilator-associated brain injury (VABI) merits urgent attention to establish whether brain-protective ventilation strategies could
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Mashup Score: 4Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 1 day(s) ago
N6-methyladenosine (m6A) plays a role in various diseases, but it has rarely been reported in acute lung injury (ALI). The FTO (fat mass and obesity-associated) protein can regulate mRNA metabolism…
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Mashup Score: 11Climate Change - 1 day(s) ago
The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is issuing a call for papers: โClimate Change: Cellular and Molecular Mechanisms Impacting Lung Pathobiology.โ This call aims to showcase work that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease either directly, or through interaction with other elements (e.g., ozone, PM2.5, allergens, pathogens). The Journal welcomes Original Research, Perspectives, Major Technical
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Farnesoid X Receptor Protects Murine Lung against IL-6โpromoted Ferroptosis Induced by Polyriboinosinic-Polyribocytidylic Acid ๐ https://t.co/YnJYthI0Ii https://t.co/zY60a36BmN