Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition. Objectives: We hypothesized that the unbiased integration of different COPD lung omics using a novel multilayer…

Exposure to high altitudes presents a unique challenge to the human body, primarily because of the reduced partial pressure of oxygen. Individuals can acclimate to higher altitudes and experience a cascade of physiological adaptations to maintain oxygen delivery to tissues despite the decreased oxygen availability. These adaptations include hyperventilation, increased hemoglobin production, and adjustments in cardiac output and stroke volume (1). Although these compensatory mechanisms are effective in

There has been an ever-expanding search for risk factors that determine a child’s risk for developing asthma. Traditional models to explain disease risk, such as gene-by-environment phenomena, have evolved to include a broader spatial landscape of environmental exposures encompassing an individual’s exposome, which individually and/or synergistically contribute to asthma development. Newer paradigms have temporally extended the search for the developmental origins of asthma to the prenatal period,