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Mashup Score: 53Frontiers | Coffee Consumption Modulates Amoxicillin-Induced Dysbiosis in the Murine Gut Microbiome - 17 hour(s) ago
The microbiome is essential for host health, and perturbations resulting from antibiotic use can lead to dysbiosis and disease. Diet can be a powerful modula…
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 7Laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty for anorectal malformation - 24 hour(s) ago
PurposeDuring the second stage surgery for anorectal malformations (ARM), patients whose distal intestine of the colostomy is particularly short underwent laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty (PCPARP). This study aimed to discuss the outcomes of PCPARP after colostomy in patients with ARM.MethodsThis is a single-center propensity score-matched (PSM) study which was retrospectively initiated patients with intermediate- or high-type ARM who underwent laparoscopic surgery from June 2007 to December 2018. These patients were divided into PCPARP group and conventional laparoscopic-assisted anorectoplasty (LAARP) group according to specific surgical methods. The general data, surgical data, postoperative complications, and functional results were evaluated.ResultsIn total, 216 patients were included in this study: 190 (88.0%) undergoing LAARP approach and 26 (12.0%) undergoing PCPARP approach. After PSM, two well-balanced groups of 26 pat
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 7Metabolic Dysregulation in Neurodegenerative Diseases - 4 day(s) ago
Several lines of evidence link metabolic dysregulation to late-life neurodegenerative diseases. The altered glucose metabolism observed in both Alzheimer’s disease (AD) and Parkinson’s disease (PD), as well as their connection to type 2 diabetes, is an area of significant interest. Notably, there is an overlap in risk factors for obesity, diabetes, and neurodegenerative diseases (particularly AD and PD) such as a lack of physical activity and excessive calorie consumption. Furthermore, variants in insulin signaling pathway genes have been associated with an increased risk of PD. In AD brains, there is a decrease in the glucose transporters GLUT1 (insulin-insensitive) and GLUT3 (insulin-sensitive) and GLUT4(insulin-sensitive). Additionally, insulin deficiency promotes tau phosphorylation and the development of neurofibrillary pathology. All together supports the role of disrupted insulin signaling in neurodegenerative disease progression.This Research Topic aims to explore the critical
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A research topic, led by Carlos Guillén, Maria Jimenez Gonzalez, and Andrea Torrao via Frontiers in Cellular Neuroscience, will explore groundbreaking research on Metabolic Dysregulation in Neurodegenerative Diseases. Deadline 24 March 2024. Read more➡️https://t.co/3MO9Lh9HX7 https://t.co/DR3Wfr2aVH
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Mashup Score: 2Bringing together multimodal and multilevel approaches to study the emergence of social bonds between children and improve social AI - 4 day(s) ago
This protocol paper outlines an innovative multimodal and multilevel approach to studying the emergence and evolution of how children build social bonds with their peers, and its potential application to improving social artificial intelligence (AI). We detail a unique hyperscanning experimental framework utilizing functional near-infrared spectroscopy (fNIRS) to observe inter-brain synchrony in child dyads during collaborative tasks and social interactions. Our proposed longitudinal study spans middle childhood, aiming to capture the dynamic development of social connections and cognitive engagement in naturalistic settings. To do so we bring together four kinds of data: the multimodal conversational behaviors that dyads of children engage in, evidence of their state of interpersonal rapport, collaborative performance on educational tasks, and inter-brain synchrony. Preliminary pilot data provide foundational support for our approach, indicating promising directions for identifying ne
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 2Frontiers | The effects of mobile phone dependence on athletic performance and its mechanisms - 4 day(s) ago
Mobile phone dependence (also known as internet dependence, MPD), defined as a problematic behavior characterized by excessive use or intermittent craving to…
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Mashup Score: 6
The emerging integration of Brain-Computer Interfaces (BCIs) in human-robot collaboration holds promise for dynamic adaptive interaction. The use of electroencephalogram (EEG)-measured error-related potentials (ErrPs) for online error detection in assistive devices offers a practical method for improving the reliability of such devices. However, continuous online error detection faces challenges such as developing efficient and lightweight classification techniques for quick predictions, reducing false alarms from artifacts, and dealing with the non-stationarity of EEG signals. Further research is essential to address the complexities of continuous classification in online sessions. With this study, we demonstrated a comprehensive approach for continuous online EEG-based machine error detection, which emerged as the winner of a competition at the 32nd International Joint Conference on Artificial Intelligence. The competition consisted of two stages: an offline stage for model developme
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Mashup Score: 12Brain organoids engineered to give rise to glia and neural networks after 90 days in culture exhibit human-specific proteoforms - 6 day(s) ago
Human brain organoids are emerging as translationally relevant models for the study of human brain health and disease. However, it remains to be shown whether human-specific protein processing is conserved in human brain organoids. Herein, we demonstrate that cell fate and composition of unguided brain organoids are dictated by culture conditions during embryoid body formation, and that culture conditions at this stage can be optimized to result in the presence of glia-associated proteins and neural network activity as early as three-months in vitro. Under these optimized conditions, unguided brain organoids generated from induced pluripotent stem cells (iPSCs) derived from male–female siblings are similar in growth rate, size, and total protein content, and exhibit minimal batch-to-batch variability in cell composition and metabolism. A comparison of neuronal, microglial, and macroglial (astrocyte and oligodendrocyte) markers reveals that profiles in these brain organoids are more sim
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Mashup Score: 10
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal intestine, causing widespread intestinal necrosis as well systemic illness that frequently results in death. Because the clinical onset of NEC is sudden and difficult to predict, NEC is considered an acute event. However, NEC does not occur in utero, meaning that postnatal exposures are required, and it does not typically occur right after birth, suggesting that longitudinal changes may be occurring before NEC can develop. In this perspective, the author considers whether NEC should be re-considered as a problem of disordered intestinal epithelial development, with required maladaptation over time prior to the onset of the necrotic event. This framework is similar to how bronchopulmonary dysplasia is currently conceptualized. They also advocate that NEC researchers incorporate this possibility into future studies on NEC susceptibility and pathogenesis. Department of Pediatrics, and the Harvard Digestive Disease Ce
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 7Laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty for anorectal malformation - 7 day(s) ago
PurposeDuring the second stage surgery for anorectal malformations (ARM), patients whose distal intestine of the colostomy is particularly short underwent laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty (PCPARP). This study aimed to discuss the outcomes of PCPARP after colostomy in patients with ARM.MethodsThis is a single-center propensity score-matched (PSM) study which was retrospectively initiated patients with intermediate- or high-type ARM who underwent laparoscopic surgery from June 2007 to December 2018. These patients were divided into PCPARP group and conventional laparoscopic-assisted anorectoplasty (LAARP) group according to specific surgical methods. The general data, surgical data, postoperative complications, and functional results were evaluated.ResultsIn total, 216 patients were included in this study: 190 (88.0%) undergoing LAARP approach and 26 (12.0%) undergoing PCPARP approach. After PSM, two well-balanced groups of 26 pat
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 6Frontiers ⎮ Participate in "Machine Learning Algorithms for Brain Imaging: New Frontiers in Neurodiagnostics and Treatment" - 7 day(s) ago
Participate in the open-access Research topic entitled “Machine Learning Algorithms for Brain Imaging: New Frontiers in Neurodiagnostics and Treatment”
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
☕ Is your morning cup of #coffee brewing up a healthier gut? 🌱 Research suggests that the fiber and polyphenols in coffee have prebiotic potential, but research in mice and humans shows mixed results. 🦠 #CoffeeScience #GutHealth https://t.co/kFoknPI1YG https://t.co/FTBdvrR89l