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Mashup Score: 2
Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in understanding how the atlas of genomic aberrations in this cancer impacts the proteome and which somatic variants are of importance for the disease phenotype.
Source: www.mcponline.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 1High-Throughput Antigen Microarray Identifies Longitudinal Prognostic Autoantibody for Chemoimmunotherapy in Advanced Non-Small Cell Lung Cancer - 12 day(s) ago
In BriefThis study screens 21,000 autoantibodies in aNSCLC patients undergoing ICIs monotherapy and chemoimmunotherapy, identifying prognostic markers—MAX, DHX29, and TAPBP AAbs—for early progression and progression-free survival. This systematic approach involves de novo screening, identification, and validation, providing clinical potential to monitor chemoimmunotherapy efficacy and detect disease progression.
Source: www.mcponline.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 10FMRP Long-Range Transport and Degradation Are Mediated by Dynlrb1 in Sensory Neurons - 7 month(s) ago
In BriefWe identified the fragile X messenger ribonucleoprotein 1 (FMRP) as one of dynein light chain roadblock 1 (Dynlrb1) interactors via proteomic analysis. FMRP granules are transported in axons of sensory neurons together with lysosomes, and Dynlrb1 mediates the association between FMRP and cytoplasmic dynein. Long-range axonal transport is critical for the regulation of FMRP granule degradation, and its alteration via genetic depletion of Dynlrb1 induces FMRP granule accumulation and consequently represses the translation of the microtubule-associated protein 1b.
Source: www.mcponline.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 0FMRP long-range transport and degradation are mediated by Dynlrb1 in sensory neurons - 7 month(s) ago
The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA binding protein (RBP) implicated in human neurodevelopmental and neurodegenerative disorders. FMRP mediates the localization and activity-dependent translation of its associated mRNAs through the formation of phase separated condensates that are trafficked by microtubule-based motors in axons. Axonal transport and localized mRNA translation are critical processes for long-term neuronal survival and are closely linked to the pathogenesis of neurological diseases.
Source: www.mcponline.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 0Home Page: Molecular & Cellular Proteomics - 1 year(s) ago
Masthead …
Source: www.mcponline.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1Home Page: Molecular & Cellular Proteomics - 1 year(s) ago
Masthead …
Source: www.mcponline.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Home Page: Molecular & Cellular Proteomics - 1 year(s) ago
Masthead …
Source: www.mcponline.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Home Page: Molecular & Cellular Proteomics - 2 year(s) ago
Masthead …
Source: www.mcponline.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Home Page: Molecular & Cellular Proteomics - 3 year(s) ago
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Source: www.mcponline.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Home Page: Molecular & Cellular Proteomics - 3 year(s) ago
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Source: www.mcponline.orgCategories: Genetics, Latest HeadlinesTweet
O’Neill et et al. explored the correlation of transcript and protein abundance using tissue-matched RNA-seq and proteomic data from 7 patients. https://t.co/fyfkCEc6I8