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Mashup Score: 0Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction - Critical Care - 6 month(s) ago
Background and Aims The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods The relationship between plasma S100A8/A9 and cardiac dysfunction was assessed in a cohort of 62 patients with severe sepsis admitted to the intensive care unit of Linköping University Hospital, Sweden. We used S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 and S100A9−/− mice for therapeutic and mechanistic studies on endotoxemia-induced cardiac dysfunction in mice. Results In sepsis patients, elevated plasma S100A8/A9 was associated with left-ventricular (LV) systolic dysfunction and increased SOFA score. In wild-type mice, 5 mg/kg of bacterial lipopolysaccharide (LPS) induced rapid plasma S100A8/A9
Source: ccforum.biomedcentral.comCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 0Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study - Critical Care - 6 month(s) ago
Background Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize transfusion practices. This study aimed to describe prophylactic platelet transfusion response, to identify factors associated with a suboptimal response, to analyse the correlation between corrected count increment and platelet count increment and to determine the association between poor platelet transfusion response and clinical outcomes. Methods This prospective multicentre observational study recruited patients who received at least one prophylactic platelet transfusion in one of the nine participating intensive care units for a period up to 16 months. Poor platelet transfusion response was defined as a corrected count increment (CCI) that adjusts for platelet dose and body surface area, less than 7 at 18–24 h after platelet transfusion. Factors associated with poor platelet transfusion response were assessed in a mixed-effect model. Sensi
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Mashup Score: 2Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk - Critical Care - 7 month(s) ago
Background Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapies. Circulating bile acids with immunosuppressive effects were recently identified in critically ill patients. These bile acids activate the monocyte G-protein coupled receptor TGR5, thereby inducing profound innate immune dysfunction. Whether these mechanisms contribute to immunosuppression and disease severity in sepsis is unknown. The aim of this study was to determine if immunosuppressive bile acids are present in endotoxemia and septic shock and, if so, which patients are particularly at risk. Methods To induce experimental endotoxemia in humans, ten healthy volunteers received 2 ng/kg E. coli lipopolysaccharide (LPS). Circulating bile acids were profiled before and after LPS administration. Furthermore, 48 patients with early (shock onset within < 24 h) and severe
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Mashup Score: 0Invasive and noninvasive devices alike have roles in diagnosing undifferentiated shock - CHEST Daily News - 7 month(s) ago
Panelists, including Max Hockstein, MD, MS, provided an overview of the available tools for determining the etiology of shock and their real-world usage during a Tuesday morning session.
Source: chestdailynews.chestnet.orgCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 2
A Wednesday morning discussion session co-chaired by Kathryn Pendleton, MD, FCCP, will look at the current problems and opportunities with the use of artificial intelligence to identify patients with sepsis or predict the onset of sepsis.
Source: chestdailynews.chestnet.orgCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 1US Elsevier Health Bookshop | Mosby, Saunders, Netter & more - 7 month(s) ago
Professional medical textbooks for the medical, dental, veterinary, nursing, and other health professional fields. Free UPS Shipping on all orders.
Source: www.us.elsevierhealth.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Attending #CHEST2023 in Hawaii? Visit us for exclusive savings on #Respiratory& #Pulmonary books! Use promo code ACCP23 at checkout and save 25% off your purchase! https://t.co/4jETwxOpwz *Valid in the U.S. @accpchest #CHESTTrainees @journal_CHEST #MedTwitter #accpchest #CritCare https://t.co/YYRyxAaC2N
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Mashup Score: 0Murray & Nadel's Textbook of Respiratory Medicin - 9780323655873 - 7 month(s) ago
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel’s Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners.
Source: www.us.elsevierhealth.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0No consensus, no problem in Pardon the Disruption debate sessions - CHEST Daily News - 7 month(s) ago
Panelists will challenge each other on controversial topics in chest medicine during an entertaining and educational game show format hosted by David Schulman, MD, MPH, FCCP.
Source: chestdailynews.chestnet.orgCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Current Use, Training, and Barriers to Point-of-Care Ultrasound Use in ICUs in the Department of Veterans Affairs - 7 month(s) ago
Point-of-care ultrasound (POCUS) has become an integral part of critical care medicine for procedural guidance, bedside diagnostics, and assessing res…
Source: www.sciencedirect.comCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Impact of Racial Differences in Hypoxia Distribution on the Measured Prevalence of Occult Hypoxemia by Pulse Oximeters - 7 month(s) ago
Racial differences in pulse oximeter accuracy increasingly have become recognized. However, previously published literature has not examined the exten…
Source: www.sciencedirect.comCategories: Latest Headlines, PulmonologyTweet
#CritCare #OpenAccess Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction Read the full article: https://t.co/2r8GybtVUI @jlvincen @ISICEM #FOAMcc #FOAMed https://t.co/00dY6Xq5gR