Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

Dysregulated human gut B and T lymphocytes contribute to the immunopathogenesis of ulcerative colitis (UC), a type of inflammatory bowel disease (IBD) characterized by mucosal damage in the colon. Boland et al . probed the immunologic perturbations associated with active UC by sequencing mRNA and clonal antigen receptors from individual CD45+ cells isolated from rectal biopsies or blood of…

IBD’s Chronic Nature May Be Due to Long-Lived Immune Cell

New findings may provide new therapeutic target and help explain why IBD and other autoimmune diseases are often chronic and life-long

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

Dysregulated human gut B and T lymphocytes contribute to the immunopathogenesis of ulcerative colitis (UC), a type of inflammatory bowel disease (IBD) characterized by mucosal damage in the colon. Boland et al . probed the immunologic perturbations associated with active UC by sequencing mRNA and clonal antigen receptors from individual CD45+ cells isolated from rectal biopsies or blood of…

Anti-TNF, thiopurine combination increase lymphoma risk in IBD

Patients with inflammatory bowel disease treated with anti-TNF either as a monotherapy or in combination with thiopurines are at increased risk for lymphoma, according to study results.

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IBD’s Chronic Nature May Be Due to Long-Lived Immune Cell

New findings may provide new therapeutic target and help explain why IBD and other autoimmune diseases are often chronic and life-long

IBD’s Chronic Nature May Be Due to Long-Lived Immune Cell

New findings may provide new therapeutic target and help explain why IBD and other autoimmune diseases are often chronic and life-long

IBD in the time of corona — vigilance for immune-mediated diseases

The gastrointestinal tract represents a target organ for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting a thorough discussion on the consequences, particularly regarding inflammatory bowel diseases. Here, aspects of gastrointestinal involvement with SARS-CoV-2, the role of viruses as modulators of mucosal immunity and as treatment-related safety hazards, and the current…

Number of antibiotic dispensations potentially linked with IBD development

Higher cumulative exposure to systemic antibiotic therapy may be associated with higher risk for the development of inflammatory bowel disease, according to research published in Lancet Gastroenterology & Hepatology.

IBD Masters Series: Taking the Path to Improved Care for Patients with Inflammatory Bowel Disease

Online virtual meeting on inflammatory bowel disease offering two scheduling options: Saturday, Sept. 12, 2020 at 9 a.m.-12:30 p.m.Sunday, Sept. 13 at 2 -5:30 p.m. The goal of this activity is to improve long-term outcomes in patients with inflammatory bowel…