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Mashup Score: 2A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring - 2 hour(s) ago
Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on public health, mainly in shaping mucosal colonization by pathobionts from the Enterobacteriaceae family, remains undetermined due to lack of relevant animal models.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults - 4 hour(s) ago
Deaths from the majority of cancers are falling globally, but the incidence and mortality from hepatocellular carcinoma (HCC) is increasing in the United Kingdom and in other Western countries. HCC is a highly fatal cancer, often diagnosed late, with an incidence to mortality ratio that approaches 1. Despite there being a number of treatment options, including those associated with good medium to long-term survival, 5-year survival from HCC in the UK remains below 20%. Sex, ethnicity and deprivation are important demographics for the incidence of, and/or survival from, HCC. These clinical practice guidelines will provide evidence-based advice for the assessment and management of patients with HCC. The clinical and scientific data underpinning the recommendations we make are summarised in detail. Much of the content will have broad relevance, but the treatment algorithms are based on therapies that are available in the UK and have regulatory approval for use in the National Health Servi
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 10Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis - 5 hour(s) ago
Objective Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins. In the present study, we investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis. Design HSC-specific or myofibroblast-specific Suv39h1 deletion was achieved by crossbreeding the Suv39h1 f/f mice to the Lrat -Cre mice or the Postn -CreERT2 mice. Liver fibrosis was induced by CCl4 injection or bile duct ligation. Results We report that Suv39h1 expression was universally upregulated during HSC-myofibroblast transition in different cell and animal models of liver fibrosis and in human cirrhotic liver tissues. Consistently, Suv39h1 knockdown blocked HSC-myofibroblast transition in vitro. HSC-specific or myofibroblast-specific deletion of Suv39h1 ameliorated liver fibrosis in mice
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 2Family planning in IBD: ‘It is our responsibility’ to share accurate resources, support - 5 hour(s) ago
A young woman, newly diagnosed with inflammatory bowel disease, sits in your office. Although she is relieved to finally have a diagnosis and a plan to treat her terrifying gastrointestinal symptoms, everything about her future now seems uncertain, including her plans to become a parent. “What ifs” and catastrophic scenarios race through her mind: She’ll never be able to
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 2Weight loss surgery more ‘cost saving’ over long term vs. semaglutide for class II obesity - 5 hour(s) ago
Endoscopic sleeve gastroplasty was more cost-effective and sustained greater weight loss over 5 years compared with semaglutide for patients with class II obesity, according to data published in JAMA Network Open. “Endoscopic sleeve gastroplasty (ESG) is the most effective endoscopic bariatric and metabolic therapy that is attracting attention worldwide,” Muhammad Haseeb, MD,
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1VIDEO: H. pylori eradication may ‘reduce burden of gastric cancer’ among vulnerable groups - 5 hour(s) ago
In a Healio video exclusive, Shria Kumar, MD, MSCE, discusses how community-based eradication of Helicobacter pylori infection may reduce the risk for gastric cancer in historically underrepresented communities and other vulnerable groups. “H. pylori is a cause of gastric cancer,” Kumar, a gastroenterologist and clinical epidemiologist at the University of Miami Miller School of
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1
More than 1,600 health care professionals celebrated the approval of Rezdiffra, the first treatment for adults with metabolic dysfunction-associated steatohepatitis, according to a global online conversation analysis by Creation Healthcare. Rezdiffra (resmetirom, Madrigal Pharmaceuticals) was granted accelerated approval by the FDA on March 14, and became available to U.S. pharmacies on April 9.
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1Budesonide does not affect engraftment, clinical response after FMT in ulcerative colitis - 5 hour(s) ago
Pretreatment with budesonide did not significantly influence engraftment among patients with ulcerative colitis who underwent fecal microbiota transplantation, with researchers reporting that clinical response appeared to be donor-dependent. “Several studies addressed the effects of FMT for UC, showing a response rate of around 36% for patients with various treatment regimens,”
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 3GLP1-RAs linked to notably higher rate of retained gastric contents during upper endoscopy - 5 hour(s) ago
More than 9% of patients on glucagon-like peptide-1 receptor agonists who underwent esophagogastroduodenoscopy had retained gastric contents, although the risk for aspiration remained low, according to study results. Further, same-day colonoscopy was reported to reduce retained gastric contents, supporting the AGA’s recent clinical practice update that recommends implementation of a liquid
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 0Vonoprazan noninferior to PPIs in preventing 30-day rebleeding in high-risk peptic ulcers - 5 hour(s) ago
Vonoprazan was noninferior to high-dose IV proton pump inhibitor therapy in preventing 30-day rebleeding among patients with high-risk peptic ulcer bleeding who had achieved endoscopic hemostasis, according to data. “Efficacy of vonoprazan has been demonstrated as noninferior to PPIs in various acid-related diseases, including erosive esophagitis, Helicobacter pylori eradication therapy,
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
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