Global Spine Journal – Volume 8, Number 4_suppl, Dec 01, 2018

Table of contents for Global Spine Journal, 8, 4_suppl, Dec 01, 2018

Genomic analysis suggests silent carriers play a role in C. diff infection

A recalcitrant and dangerous intestinal bacterium, Clostridioides difficile causes some half a million infections in the United States each year, many of them recurrent and some of them fatal.

Why COVID-19 infection curves behave so unexpectedly

With the first COVID-19 epidemic peak behind them, many countries explained the decrease of infection numbers through non-pharmaceutical interventions. Phrases like “social distancing” and “flatten the curve” have become part of common vocabulary. Yet some explanations fell short: How could one explain the linear rise of infection curves, which many countries display after the first peak, in…

Severe viral infection overwhelms immune cells

Melbourne researchers have identified mechanisms leading to the functional deterioration of the immune system in response to severe viral infections, such as HIV or COVID-19.

Nasal vaccine against COVID-19 prevents infection in mice

Scientists at Washington University School of Medicine in St. Louis have developed a vaccine that targets the SARS-CoV-2 virus, can be given in one dose via the nose and is effective in preventing infection in mice susceptible to the novel coronavirus. The investigators next plan to test the vaccine in nonhuman primates and humans to see if it is safe and effective in preventing COVID-19…

Vaccine that harnesses antifungal immunity protects mice from staph infection

Immunization of mice with a new vaccine consisting of fungal particles loaded with Staphylococcus aureus (S. aureus) proteins protects mice against S. aureus infection, according to a study published August 20 2020 in the open-access journal PLOS Pathogens by David Underhill of Cedars-Sinai Medical Center, and colleagues.

Bone & Joint Research

Cemented prosthesis as spacer for two-stage revision of infected hip prostheses: a similar infection remission rate and a lower complication rate

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

A SARS-CoV-2 hACE2 transgenic mouse infection model recapitulates a number of infection symptoms and pathology in COVID-19 patients. Pre-exposure to SARS-CoV-2 was able to protect mice from severe pneumonia.

Preoperative epidural steroid injections are not associated with increased rates of infection and dural tear in lumbar spine surgery | European Spine Journal

PurposeThe study objectives were to use a large national claims data resource to examine rates of preoperative epidural steroid injections (ESI) in lumbar spine surgery and determine whether preoperative ESI or the timing of preoperative ESI is associated with rates of postoperative comp

Scientists show how parasitic infection causes seizures, psychiatric illness for some

Think about traffic flow in a city—there are stop signs, one-way streets, and traffic lights to organize movement across a widespread network. Now, imagine what would happen if you removed some of the traffic signals.