SARS-CoV-2 infection in the COPD population is associated with increased healthcare utilization: An analysis of Cleveland clinic’s COVID-19 registry

Our analysis demonstrated that COPD patients with COVID-19 had a higher risk for healthcare utilization, although adjusted in-hospital mortality risk was not different than the non-COPD patients with COVID-19.

Dexamethasone may be part of the Covid-19 puzzle but it’s no magic bullet | Devi Sridhar

If this cheap steroid reduces deaths in critically ill patients that’s great news, and one small step towards managing coronavirus, says public health professor Devi Sridhar

Four scenarios on how we might develop immunity to Covid-19

As the world wearies of trying to suppress the SARS-CoV-2 virus, many of us are wondering what the future will look like as we try to learn to live with it.

COVID-19 vaccine trials should seek worthwhile efficacy

Three issues are crucial in planning COVID-19 vaccine trials: (1) whether to demand not only proof of some vaccine efficacy but also proof of worthwhile efficacy; (2) whether the initial trials of vaccine against placebo should prioritise not only single-vaccine trials but also a multivaccine trial; and (3) whether to assess safety, protection against severe disease, and duration of protection by…

Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic

This quality improvement study assesses surface contamination with SARS-CoV-2 in the radiation oncology department of a large COVID-19 referral center and discusses implications for routine cleaning and disinfecting practices.

Beating HIV and COVID-19 may depend on tweaking vaccine molecules | La Jolla Institute for Immunology

La Jolla Institute for Immunology. We have relied on the strength of our people and the quality of our research.

Test Sensitivity for Infection versus Infectiousness of SARS-CoV-2 by Joshua S. Gans :: SSRN

The most commonly used test for the presence of SARS-CoV-2 is a PCR test that is able to detect very low viral loads and inform on treatment decisions. Medical

An inflammatory cytokine signature predicts COVID-19 severity and survival

Elevated levels of serum IL-6 and TNF-α at the time of hospitalization are independent and significant predictors of clinical outcome in two cohorts of patients with COVID-19.

Trump set to announce purchase of 150M rapid coronavirus tests

The move would represent a significant expansion of the nation’s coronavirus testing.

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

Recent outbreaks of Ebola virus (EBOV) and SARS-CoV-2 have exposed our limited therapeutic options and poor understanding of cellular mechanisms that block viral infections. Using a transposon-mediated gene-activation screen in human cells, we identify that the MHC class II transactivator (CIITA) has antiviral activity against EBOV. CIITA induces resistance by activating expression of the p41…