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Mashup Score: 3Effect of Air Flow Rate Over Time on SARS-CoV-2 Viability During Representative Sampling Using MD8 Airport Air Sampler - 13 hour(s) ago
Studies involving air sampling for SARS-CoV-2 commonly return either negative data or non-viable virus. We assessed the desiccative impact of time parameters during air sampling by aerosolising SARS-CoV-2 onto gelatine Sartorius MD8 AirPort filters; contaminated filters were then attached to a Sartorius MD8 AirPort and run at 50L/min up to 40 minutes. These filters were then analysed by viral plaque assay and qRT-PCR, results showed no significant difference in recovery of infectious virus or genomic copy numbers with increasing air sampled.
Categories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 1SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses | PNAS - 19 day(s) ago
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 nonst…
Source: www.pnas.orgCategories: General Medicine News, Infectious DiseaseTweet-
😷 Scientists focus on the #SARSCoV2 nonstructural protein 15 and demonstrate that its endoribonuclease activity delays the activation of antiviral responses in human lung cells. @PNASNews | https://t.co/tRkMdVUmzD https://t.co/xQbMGTlvZC
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Mashup Score: 0Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates - 20 day(s) ago
Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.
Source: www.science.orgCategories: General Medicine News, Infectious DiseaseTweet-
💉 Ancestral #SARSCoV2 spike mRNA vaccines lacking proline substitutions can induce B cell lineages binding to distinct RBD sites that either broadly neutralize sarbecoviruses or neutralize recent Omicron variant of concerns. 👉 @ScienceTM | https://t.co/m3Mb9ISnpo https://t.co/Jf7otevZSR
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Mashup Score: 0Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study | Circulation - 25 day(s) ago
BACKGROUND: Despite the significant global impact of the COVID-19 pandemic, limited studies have investigated the long-term cardiovascular sequelae of SARS-CoV-2 infection, particularly among Asian populations. This large-scale, population-based binational cohort study with long-term follow-up aimed to investigate the association between SARS-CoV-2 infection and the risk of cardiovascular events. METHODS: We used binational, large-scale, and population-based cohorts, including a Korean nationwide cohort (K-COV-N; discovery cohort; n=18 989 129) and a Japanese nationwide cohort (Japan Medical Data Center; validation cohort; n=12 218 680). Individuals aged 20 years or older were included from January 1, 2020, to December 31, 2022. We assessed the long-term risk of incident cardiovascular outcomes after SARS-CoV-2 infection. The primary outcome was the risk of cardiovascular diseases based on International Classification of Diseases, Tenth Revision code diagnosis. After propensity score–b
Source: www.ahajournals.orgCategories: General Medicine News, Infectious DiseaseTweet-
😷 This large-scale, population-based binational cohort study with long-term follow-up investigated the association between #SARSCoV2 infection and the risk of cardiovascular events. 💓 @CircAHA | https://t.co/DWJhg7LT28 https://t.co/fRPyoiEDvC
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Mashup Score: 3
Nature Communications – This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet-
😷 Dr. Caner Akil and researchers at @UniofOxford designed a near-native viral fusion system that recapitulates #SARSCoV2 entry and use cryo-electron tomography to capture fusion intermediates leading to complete fusion. @NatureComms | https://t.co/ZQeFfTcYcw https://t.co/lVbLBH9gOT
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Mashup Score: 0Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity - 2 month(s) ago
The nucleocapsid protein (NP) of SARS-CoV-2, an RNA-binding protein, is capable of undergoing liquid-liquid phase separation (LLPS) during viral infection, which plays a crucial role in virus assem…
Source: www.tandfonline.comCategories: General Medicine News, Infectious DiseaseTweet-
🔬 Researchers developed a homogeneous time-resolved fluorescence method for identifying inhibitors of the #SARSCoV2 cleoprotein-RNA interaction. 🔗 https://t.co/hHFZmKDiYi https://t.co/viQbVupgvV
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Mashup Score: 3ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery - 3 month(s) ago
Scientific Reports – ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet-
😷 Researchers at @NUSingapore found that ACE2 and TMPRSS2 gene expression was temporarily reduced during the acute phase of #SARSCoV2 infection presumably due to viral disruption of transcription. 📖 @SciReports | https://t.co/ZOHQb0y9BQ https://t.co/lzt21B3096
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Mashup Score: 1Kidney Function Following COVID-19 in Children and Adolescents - 3 month(s) ago
This cohort study investigates the association of SARS-CoV-2 infection with risk of postacute adverse kidney outcomes among children and adolescents.
Source: jamanetwork.comCategories: General Medicine NewsTweet-
Children and adolescents with #SARSCoV2 infection are at an increased risk of adverse post-acute kidney outcomes, especially those with preexisting chronic kidney disease or acute kidney injury. https://t.co/iTMtVj2x4f @PennCIL_lab @becich
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Mashup Score: 379
Nature – Two distinct patterns in the protective effect of natural infection against reinfection in the Omicron variant versus pre-Omicron eras show that SARS-CoV-2 immune protection is shaped by…
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet-
On the big shift of #SARSCoV2 when Omicron came along, with a profound drop in protection from prior Covid or vaccination--> reinfections https://t.co/msdvCDD1Va @Nature @HChemaitelly @BertolliniR @Laith_AbuRaddad https://t.co/TKAdvMtUIA
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Mashup Score: 364
Nature – Two distinct patterns in the protective effect of natural infection against reinfection in the Omicron variant versus pre-Omicron eras show that SARS-CoV-2 immune protection is shaped by…
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet-
On the big shift of #SARSCoV2 when Omicron came along, with a profound drop in protection from prior Covid or vaccination--> reinfections https://t.co/msdvCDD1Va @Nature @HChemaitelly @BertolliniR @Laith_AbuRaddad https://t.co/TKAdvMtUIA
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Authors assessed the desiccative impact of time parameters during air sampling by aerosolising #SARSCoV2 onto gelatine filters; contaminated filters were attached to a MD8 AirPort and run at 50L/min. Sampling for 40 minutes or less did not reduce viability https://t.co/7lb9mxfEZK