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Mashup Score: 1096SARS and synapses - 3 day(s) ago
Nature Microbiology – SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle…
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 400Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence - 4 day(s) ago
Nature Microbiology – Targeted accurate RNA consensus sequencing enables study of de novo errors caused by RNA-dependent RNA polymerases and provides deeper insights into how SARS-CoV-2 genetic…
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 34Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models - 4 day(s) ago
Nature Communications – Here the authors screen different lipid nanoparticle (LNP) formulations for intramuscular delivery of plasmid DNA and uptake by antigen-presenting cells. The lead LNP…
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Mashup Score: 2SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity - 7 day(s) ago
Abstract. It has been proposed that coronavirus nsp15 mediates evasion of host cell double-stranded (ds) RNA sensors via its uracil-specific endoribonuclea
Source: academic.oup.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 9Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models - 7 day(s) ago
Nature Communications – Here the authors screen different lipid nanoparticle (LNP) formulations for intramuscular delivery of plasmid DNA and uptake by antigen-presenting cells. The lead LNP…
Source: www.nature.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 548Age-specific nasal epithelial responses to SARS-CoV-2 infection - 11 day(s) ago
Nature Microbiology – Age-specific differences upon SARS-CoV-2 infection are marked by emergence of goblet 2 inflammatory cells expressing antiviral interferon stimulating genes in paediatric nasal…
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Mashup Score: 2430stats - 26 day(s) ago
The 2023-2024 fall and winter virus season, four years since the start of the COVID-19 pandemic, provided ongoing evidence of the changing face of respiratory diseases. COVID-19 remains an important public health threat, but it is no longer the emergency that it once was, and its health impacts increasingly resemble those of other respiratory viral illnesses, including influenza and RSV. This reality enables CDC to provide updated guidance proportionate to the current level of risk COVID-19 poses while
Source: www.cdc.govCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 510COVID Data Tracker - 28 day(s) ago
CDC’s home for COVID-19 data. Visualizations, graphs, and data in one easy-to-use website.
Source: covid.cdc.govCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 588Effect of molnupiravir on SARS-CoV-2 evolution in immunocompromised patients: a retrospective observational study - 1 month(s) ago
Molnupiravir treatment in immunocompromised patients led to the accumulation of a distinctive pattern of mutations beyond the recommended 5 days of treatment. Treated patients maintained persistent PCR positivity for the duration of monitoring, indicating clear potential for transmission and subsequent emergence of novel variants.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 1403Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1 - 1 month(s) ago
The SARS-CoV-2 variant JN.1 swiftly became the global dominant strain1,2 due to a spike protein Leu455Ser substitution, boosting transmissibility and immune-escape capabilities, surpassing its predecessor BA.2.86 and other variants.1,3,4 These alterations have resulted in a surge of COVID-19 cases, reflected in wastewater-surveillance data surpassing rates, observed during the initial omicron wave. However, concerns persist that JN.1 might have an increased capacity to replicate in the gut, potentially leading to infected individuals shedding a higher number of viral copies than previously seen.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet
How #SARSCoV2 can disrupt brain synapses https://t.co/15tEia5uGJ https://t.co/NpgIBi6gmg Increased expression of 3 synaptic proteins, and finding a drug that restores synaptic function @NatureMicrobiol https://t.co/ofleGVNzIL