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Mashup Score: 2
Affiliations Digestive Disease Institute, Cleveland Clinic Florida, Weston, FL 33331 Already an on line subscriber? In Press Journal Pre-Proof Conflict of interest: T. Shah: Consultant, Steris
Source: www.giejournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1Registration Options - 5 hour(s) ago
We’ve broken down the differences between in-person and online registration and what’s included with each option.
Source: ddw.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 4The Lancet Gastroenterology and Hepatology: Homepage - 7 hour(s) ago
Discover articles from The Lancet Gastroenterology & Hepatology, providing a clear, independent perspective about the clinical advances and practice-changing research shaping your specialty globally
Source: www.thelancet.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 2Endoscopic closure of refractory external pancreatic fistula by injecting metal coil in the fistula tract - 8 hour(s) ago
A 34-year-old woman underwent distal pancreatectomy for mucinous cystadenoma. Postoperatively she experienced an external pancreatic fistula (EPF) with a daily drain output of 300 to 500 mL/day of amylase-rich fluid. After 3 weeks of conservative treatment had failed, she underwent endoscopic retrograde pancreatography (ERP). The pancreatic duct (PD) was disrupted at the distal end, with extravasation of contrast material into the fistula tract. After pancreatic sphincterotomy, a 7F 10-cm transpapillary PD stent was placed.
Source: www.giejournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1AGA Offers New Guidance on FMT Therapies To Prevent C. diff - 9 hour(s) ago
Treatment with FMT is effective for preventing recurrent C. diff infection in adults with robust immune systems, for whom standard antibiotics do not eliminate the bacterium.
Source: www.gastroendonews.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 1Asian American Pacific Islander Heritage Month 2024 - 9 hour(s) ago
by Dr. Mazer Ally, Dr. Sujaata Dwadasi, Dr. Corlan Eboh, Dr. Raj Jessica Thomas; ACG Diversity, Equity, and Inclusion Committee…
Source: gi.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 0Gut: 73 (5) - 9 hour(s) ago
(21 November, 2023) Emily L Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O’Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Rebecca C Fitzgerald (8 February, 2024) Free Kurtis F Budden, Shakti D Shukla, Kate L Bowerman, Annalicia Vaughan, Shaan L Gellatly, David L A Wood, Nancy Lachner, Sobia Idrees, Saima Firdous Rehman, Alen Faiz, Vyoma K Patel, Chantal Donovan, Charlotte
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 33Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease - 10 hour(s) ago
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell’s C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of li
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImages from the paper by @AngeloArmandi et al on "Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease" via https://t.co/oap3sTWjmt @DinaTiniakos @lucavalenti75 @lmiele74 @hanneshagstrom @mromerogomez https://t.co/6KG8WdxzSU
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Mashup Score: 14TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism - 10 hour(s) ago
Objective Achieving HBV cure will require novel combination therapies of direct-acting antivirals and immunomodulatory agents. In this context, the toll-like receptor 8 (TLR8) agonist selgantolimod (SLGN) has been investigated in preclinical models and clinical trials for chronic hepatitis B (CHB). However, little is known regarding its action on immune effectors within the liver. Our aim was to characterise the transcriptomic changes and intercellular communication events induced by SLGN in the hepatic microenvironment. Design We identified TLR8 -expressing cell types in the human liver using publicly available single-cell RNA-seq data and established a method to isolate Kupffer cells (KCs). We characterised transcriptomic and cytokine KC profiles in response to SLGN. SLGN’s indirect effect was evaluated by RNA-seq in hepatocytes treated with SLGN-conditioned media (CM) and quantification of HBV parameters following infection. Pathways mediating SLGN’s effect were validated using tran
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 0Patients with delayed diagnosis of appendicitis had 1.23-times higher hospital care costs - 11 hour(s) ago
A delayed diagnosis of appendicitis was associated with an increase in hospital care costs in a cohort of adults who underwent appendectomy, particularly among non-Hispanic Black patients, according to data in JAMA Network Open. “Delayed diagnoses have resulted in increased appendectomy length of stay and 30-day readmissions,” Dinushi A. Kulasekere, BS, of Northwestern University
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet
Online now in GIE’s Articles in Press: “Top tips for endoscopic management of malignant esophageal obstruction" by Tilak Shah. https://t.co/EHoUWkfU2n https://t.co/AEpw92jmXU