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Mashup Score: 11BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib - 12 day(s) ago
Key Points. BCR::ABL1 M244V confers clinical resistance to asciminib; M244V and other kinase N-lobe mutations confer resistance to asciminib in vitroMutati
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Mashup Score: 49The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia - 3 month(s) ago
Fabre and Vassiliou review the current understanding of the natural history of clonal hematopoiesis (CH) and its relationship to myeloid malignancy. Increasing
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Mashup Score: 52Clonal hematopoiesis and autoimmunity - 3 month(s) ago
Clonal hematopoiesis (CH) has been associated with aging, occurring in about 10% of individuals aged > 70 years, and immune dysfunction. Aged hematopo…
Source: www.sciencedirect.comCategories: General Medicine News, Partners & KOLsTweet-
Exploring the intricate dance between #CH and autoimmunity. Our latest review article with @rheumrob & @VisconteValeria shedding light on the complex interplay of genetics and inflammation. #CHIP #VEXAS #Autoimmunity Clonal hematopoiesis and autoimmunity https://t.co/JJHJZvCl7p https://t.co/15dobjGip6
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Mashup Score: 98Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk - 4 month(s) ago
Blood Cancer Journal – Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk
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Mashup Score: 31Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML - 5 month(s) ago
Key Points. Mezigdomide potently degrades IKAROS, conferring broader activity in KMT2A-r and NPM1c AML models compared to lenalidomide and iberdomide.Mezigdomid
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Mashup Score: 28IDH1-mutant preleukemic hematopoietic stem cells can be eliminated by inhibition of oxidative phosphorylation - 5 month(s) ago
Abstract. Rare preleukemic hematopoietic stem cells (pHSCs) harboring only the initiating mutations can be detected at the time of AML diagnosis. pHSCs are the origin of leukemia and a potential reservoir for relapse. Using primary human samples and gene-editing to model isocitrate dehydrogenase 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, and metabolic differences between pHSCs and healthy hematopoietic stem cells (HSCs). We confirm that IDH1 driven clonal hematopoiesis is associated with cytopenia, suggesting an inherent defect to fully reconstitute hematopoiesis. Despite giving rise to multilineage engraftment, IDH1-mutant pHSCs exhibited reduced proliferation, blocked differentiation, downregulation of MHC Class II genes, and reprogramming of oxidative phosphorylation metabolism. Critically, inhibition of oxidative phosphorylation resulted in complete eradication of IDH1-mutant pHSCs but not IDH2-mutant pHSCs or wildtype HSCs. Our results indicate that IDH1-mutant pr
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Mashup Score: 47VEXAS syndrome: Clinical, hematologic features and a practical approach to diagnosis and management - 6 month(s) ago
The American Journal of Hematology publishes research in blood diseases in humans & animal model, covering all hematological diseases including leukemia, hemostasis and thrombosis.
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Mashup Score: 25Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline - 6 month(s) ago
An official journal of the British Society for Haematology, the British Journal of Haematology offers high visibility for clinical, basic and translational research.
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Mashup Score: 22
Isolated thrombocytosis, defined as a platelet (PLT) count higher than 450×109/L, is mainly secondary to reactive conditions or, more rarely, a consequence of primary disorders arising in the bone marrow. The typical primary thrombocytosis is essential thrombocythemia (ET), a clonal acquired disorder belonging to Philadelphia-negative myeloproliferative neoplasms (MPN). In more than 90% of cases, ET is driven by JAK2 V617F mutation or by somatic mutations in exon 9 of CALR or in exon 10 of MPL, while the remaining cases are termed “triple-negative”.
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Mashup Score: 2JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study - 7 month(s) ago
Key Points. The JAK2V617F mutation prevalence in patients with ischemic stroke is 11.3%.Patients with ischemic stroke are 2.4 times more likely to have the JAK2
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BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib https://t.co/FSlV2QjWQy